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Itgb4 integrin subunit beta 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25724, updated on 19-Apr-2019

Summary

Official Symbol
Itgb4provided by RGD
Official Full Name
integrin subunit beta 4provided by RGD
Primary source
RGD:2928
See related
Ensembl:ENSRNOG00000005580
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
beta subunit of integrin alpha6/beta4 which is a cell surface receptor for laminin; involved in hemidesmosome formation [RGD, Feb 2006]
Annotation information
Annotation category: partial on reference assembly
Expression
Biased expression in Thymus (RPKM 62.0), Muscle (RPKM 43.9) and 9 other tissues See more
Orthologs

Genomic context

See Itgb4 in Genome Data Viewer
Location:
10q32.1
Exon count:
40
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (104524000..104560180)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (103725179..103761358, complement)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene SAP30 binding protein Neighboring gene ribosomal protein S18-like 1 Neighboring gene galactokinase 1 Neighboring gene H3 histone family member 3B

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
cell adhesion molecule binding TAS
Traceable Author Statement
more info
PubMed 
insulin-like growth factor I binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to insulin-like growth factor I binding ISO
Inferred from Sequence Orthology
more info
PubMed 
contributes_to insulin-like growth factor I binding ISS
Inferred from Sequence or Structural Similarity
more info
 
integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuregulin binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to neuregulin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
contributes_to neuregulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
amelogenesis IEA
Inferred from Electronic Annotation
more info
 
amelogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
autophagy IEA
Inferred from Electronic Annotation
more info
 
autophagy ISO
Inferred from Sequence Orthology
more info
PubMed 
cell adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell motility IEA
Inferred from Electronic Annotation
more info
 
cell motility ISO
Inferred from Sequence Orthology
more info
PubMed 
cell motility ISS
Inferred from Sequence or Structural Similarity
more info
 
cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 
digestive tract development IEA
Inferred from Electronic Annotation
more info
 
digestive tract development ISO
Inferred from Sequence Orthology
more info
PubMed 
filopodium assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
hemidesmosome assembly IEA
Inferred from Electronic Annotation
more info
 
hemidesmosome assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
mesodermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
mesodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
myelination in peripheral nervous system ISO
Inferred from Sequence Orthology
more info
PubMed 
nail development IEA
Inferred from Electronic Annotation
more info
 
nail development ISO
Inferred from Sequence Orthology
more info
PubMed 
peripheral nervous system myelin formation ISO
Inferred from Sequence Orthology
more info
PubMed 
renal system development IEA
Inferred from Electronic Annotation
more info
 
renal system development ISO
Inferred from Sequence Orthology
more info
PubMed 
response to wounding IEA
Inferred from Electronic Annotation
more info
 
response to wounding ISO
Inferred from Sequence Orthology
more info
PubMed 
response to wounding ISS
Inferred from Sequence or Structural Similarity
more info
 
skin development IEA
Inferred from Electronic Annotation
more info
 
skin development ISO
Inferred from Sequence Orthology
more info
PubMed 
trophoblast cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
basal plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
basement membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cell junction ISO
Inferred from Sequence Orthology
more info
 
cell leading edge IEA
Inferred from Electronic Annotation
more info
 
cell leading edge ISO
Inferred from Sequence Orthology
more info
PubMed 
cell leading edge ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
extracellular space TAS
Traceable Author Statement
more info
PubMed 
focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hemidesmosome IEA
Inferred from Electronic Annotation
more info
 
hemidesmosome ISO
Inferred from Sequence Orthology
more info
PubMed 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin complex IEA
Inferred from Electronic Annotation
more info
 
integrin complex ISO
Inferred from Sequence Orthology
more info
PubMed 
integrin complex TAS
Traceable Author Statement
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
integrin beta-4
Names
GP150

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013180.1NP_037312.1  integrin beta-4 precursor

    See identical proteins and their annotated locations for NP_037312.1

    Status: PROVISIONAL

    Source sequence(s)
    U60096
    UniProtKB/Swiss-Prot
    Q64632
    Related
    ENSRNOP00000073188.1, ENSRNOT00000086747.1
    Conserved Domains (6) summary
    smart00237
    Location:9921086
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    cd00063
    Location:12221315
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:16261711
    fn3; Fibronectin type III domain
    pfam00362
    Location:37454
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:628712
    Integrin_B_tail; Integrin beta tail domain
    pfam07974
    Location:544574
    EGF_2; EGF-like domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    104524000..104560180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    99781746..99817137
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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