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Scn4a sodium voltage-gated channel alpha subunit 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25722, updated on 17-Jul-2021

Summary

Official Symbol
Scn4aprovided by RGD
Official Full Name
sodium voltage-gated channel alpha subunit 4provided by RGD
Primary source
RGD:3636
See related
Ensembl:ENSRNOG00000012134
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
NCHVS; Nav1.4; microI
Summary
voltage-gated Na+ channel subunit [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 389.5) See more
Orthologs
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Genomic context

See Scn4a in Genome Data Viewer
Location:
10q32.1
Exon count:
26
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (91246936..91296670, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (94505026..94557803, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene growth hormone 1 Neighboring gene CD79b molecule Neighboring gene uncharacterized LOC120095299 Neighboring gene uncharacterized LOC108352146 Neighboring gene proline rich 29 Neighboring gene intercellular adhesion molecule 2 Neighboring gene endoplasmic reticulum to nucleus signaling 1 Neighboring gene 40S ribosomal protein S10-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables voltage-gated sodium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated sodium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated sodium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables voltage-gated sodium channel activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cation transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in choline transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane depolarization during action potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuronal action potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in potassium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of skeletal muscle contraction by action potential IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of skeletal muscle contraction by action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of skeletal muscle contraction by action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sodium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of voltage-gated sodium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of voltage-gated sodium channel complex IEA
Inferred from Electronic Annotation
more info
 
part_of voltage-gated sodium channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated sodium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
sodium channel protein type 4 subunit alpha
Names
Sodium channel voltage-gated type IV alpha polypeptide
mu-1
skM1
sodium channel protein skeletal muscle subunit alpha
sodium channel protein type IV subunit alpha
sodium channel, voltage-gated, type 4, alpha polypeptide
sodium channel, voltage-gated, type 4, alpha subunit
sodium channel, voltage-gated, type IV, alpha polypeptide
sodium channel, voltage-gated, type IV, alpha subunit
voltage-gated sodium channel subunit alpha Nav1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013178.2NP_037310.2  sodium channel protein type 4 subunit alpha

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000220
    Related
    ENSRNOP00000016841.4, ENSRNOT00000016841.4
    Conserved Domains (3) summary
    cd13433
    Location:12891341
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:10231297
    Ion_trans; Ion transport protein
    pfam06512
    Location:8101019
    Na_trans_assoc; Sodium ion transport-associated

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    91246936..91296670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247559.4XP_006247621.1  sodium channel protein type 4 subunit alpha isoform X1

    UniProtKB/TrEMBL
    D3ZW75
    Conserved Domains (3) summary
    cd13433
    Location:12891341
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:10231297
    Ion_trans; Ion transport protein
    pfam06512
    Location:8101019
    Na_trans_assoc; Sodium ion transport-associated
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