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GPX6 glutathione peroxidase 6 [ Homo sapiens (human) ]

Gene ID: 257202, updated on 5-Mar-2024


Official Symbol
GPX6provided by HGNC
Official Full Name
glutathione peroxidase 6provided by HGNC
Primary source
See related
Ensembl:ENSG00000198704 MIM:607913; AllianceGenome:HGNC:4558
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPX5p; GPXP3; GPx-6; GSHPx-6; dJ1186N24; dJ1186N24.1
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. Expression of this gene has been observed in embryos and olfactory epithelium; however, the exact function of this gene is not known. This isozyme is a selenoprotein in humans, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The orthologs of this gene in mouse and rat (and some other species) contain a cysteine (Cys) residue in place of the Sec residue, and their corresponding mRNAs lack SECIS element. [provided by RefSeq, Jul 2017]
Low expression observed in reference dataset See more
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Genomic context

Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (28503296..28515793, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (28374721..28387222, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (28471073..28483570, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901294 Neighboring gene uncharacterized LOC124901295 Neighboring gene tRNA-Thr (anticodon CGT) 1-1 Neighboring gene MPRA-validated peak5745 silencer Neighboring gene glutathione peroxidase 5 Neighboring gene tRNA-Ile (anticodon TAT) 3-1

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat causes a greater than 50% decrease in intracellular reduced glutathione (GSH), leading to the extracellular appearance of acidic FGF-1, an effect that is partially mediated through modulation of GSH biosynthetic enzymes PubMed
tat Expression of HIV-1 Tat in HeLa cells downregulates cytoplasmic glutathione peroxidase while upregulating phospholipid hydroperoxide glutathione peroxidase, thereby deregulating intracellular oxidant/antioxidant balance and amplifying UV sensitivity PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

General gene information


Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glutathione peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
glutathione peroxidase 6
glutathione peroxidase 6 (olfactory)
selenoprotein GPX6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182701.1NP_874360.1  glutathione peroxidase 6 precursor

    See identical proteins and their annotated locations for NP_874360.1

    Status: REVIEWED

    Source sequence(s)
    Consensus CDS
    P59796, Q4PJ17
    ENSP00000354581.1, ENST00000361902.5
    Conserved Domains (1) summary
    GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    28503296..28515793 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2


  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    632..5674 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060930.1 Alternate T2T-CHM13v2.0

    28374721..28387222 complement
    GenBank, FASTA, Sequence Viewer (Graphics)