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GPX6 glutathione peroxidase 6 [ Homo sapiens (human) ]

Gene ID: 257202, updated on 29-Mar-2018

Summary

Official Symbol
GPX6provided by HGNC
Official Full Name
glutathione peroxidase 6provided by HGNC
Primary source
HGNC:HGNC:4558
See related
Ensembl:ENSG00000198704 MIM:607913; Vega:OTTHUMG00000044828
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPX5p; GPXP3; GPx-6; GSHPx-6; dJ1186N24; dJ1186N24.1
Summary
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. Expression of this gene has been observed in embryos and olfactory epithelium; however, the exact function of this gene is not known. This isozyme is a selenoprotein in humans, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The orthologs of this gene in mouse and rat (and some other species) contain a cysteine (Cys) residue in place of the Sec residue, and their corresponding mRNAs lack SECIS element. [provided by RefSeq, Jul 2017]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See GPX6 in Genome Data Viewer
Location:
6p22.1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (28503296..28515793, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (28471073..28483570, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene tRNA methionine elongator pseudogene 1 Neighboring gene transfer RNA-Thr (CGT) 1-1 Neighboring gene glutathione peroxidase 5 Neighboring gene transfer RNA-Ile (TAT) 3-1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat causes a greater than 50% decrease in intracellular reduced glutathione (GSH), leading to the extracellular appearance of acidic FGF-1, an effect that is partially mediated through modulation of GSH biosynthetic enzymes PubMed
tat Expression of HIV-1 Tat in HeLa cells downregulates cytoplasmic glutathione peroxidase while upregulating phospholipid hydroperoxide glutathione peroxidase, thereby deregulating intracellular oxidant/antioxidant balance and amplifying UV sensitivity PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutathione peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glutathione peroxidase 6
Names
glutathione peroxidase 6 (olfactory)
NP_874360.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182701.1NP_874360.1  glutathione peroxidase 6 precursor

    See identical proteins and their annotated locations for NP_874360.1

    Status: REVIEWED

    Source sequence(s)
    AY324826
    Consensus CDS
    CCDS43432.1
    UniProtKB/Swiss-Prot
    P59796
    Related
    ENSP00000354581.1, OTTHUMP00000042350, ENST00000361902.5, OTTHUMT00000104340
    Conserved Domains (1) summary
    cd00340
    Location:39211
    GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    28503296..28515793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p12 ALT_REF_LOCI_2

    Range
    632..5674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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