Igf1r insulin-like growth factor 1 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Igf1rprovided by RGD
Official Full Name: insulin-like growth factor 1 receptorprovided by RGD
Primary source: RGD:2869
See related: Ensembl:ENSRNOG00000014187
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Igfr1; JTK13; IGFIRC; IGF-1 receptor
Summary: receptor for Igf-1; involved in induction of cell cycle progression and survival in many cell types [RGD, Feb 2006]
Expression: Biased expression in Adrenal (RPKM 154.5), Kidney (RPKM 119.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
106	current	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (128924921..129213816)
106	current	Rn_Celera (GCF_000002265.2)	1	AC_000069.1 (113751636..114029884)
104	previous assembly	Rnor_5.0 (GCF_000001895.4)	1	NC_005100.3 (129985761..130272589)

Chromosome 1 - NC_005100.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Doublecortin and IGF-1R protein levels are reduced in spite of unchanged DNA methylation in the hippocampus of aged rats.
Title: Doublecortin and IGF-1R protein levels are reduced in spite of unchanged DNA methylation in the hippocampus of aged rats.
Neural Stem Cell Transplantation Improves Locomotor Function in Spinal Cord Transection Rats Associated with Nerve Regeneration and IGF-1 R Expression.
Title: Neural Stem Cell Transplantation Improves Locomotor Function in Spinal Cord Transection Rats Associated with Nerve Regeneration and IGF-1 R Expression.
Hrd1 might mediate the ubiquitination of IGF-1R through sema3a and then participate in the regulation of cardiomyocyte apoptosis.
Title: Hrd1 induces cardiomyocyte apoptosis via regulating the degradation of IGF-1R by sema3a.
MMP-dependent receptor cleavage contributed to the reduced IGF-1 response in hypertension.
Title: IGF-1 receptor cleavage in hypertension.
miR-503 promoted cell apoptosis, caused mitochondrial membrane potential collapse and the emancipation of cyto C from mitochondrial through PI3K/Akt pathway via targeting IGF-1R in H9c2 cardiomyocytes.
Title: MicroRNA-503 regulates hypoxia-induced cardiomyocytes apoptosis through PI3K/Akt pathway by targeting IGF-1R.
IGF-1R participates in estradiol-17beta-D-glucuronide-induced impairment of canalicular secretory function. Knock-down of IGF-1R prevents both the impairment of Abcc2 transport activity and the endocytic internalization of transporters.
Title: Activation of insulin-like growth factor 1 receptor participates downstream of GPR30 in estradiol-17β-D-glucuronide-induced cholestasis in rats.
Our data indicates that activation of IGF-1R and/or the IR autocrine loops resulting in beta-cell protection and function, involve mechanisms independent to the enhanced metabolic effects resulting from sustained GLP-1R activation
Title: Insulin and IGF-1 receptor autocrine loops are not required for Exendin-4 induced changes to pancreatic β-cell bioenergetic parameters and metabolism in BRIN-BD11 cells.
overexpression of decorin ameliorated diabetic cardiomyopathy and promoted angiogenesis through the IGF1R-AKT-VEGF signaling pathway in vivo and in vitro.
Title: Overexpression of decorin promoted angiogenesis in diabetic cardiomyopathy via IGF1R-AKT-VEGF signaling.
Mechanical stretch regulated L6 myoblasts proliferation, which may be mediated by the changes in PI3K/Akt and MAPK activations regulated by IGF-1R, despite no detectable IGF-1 from stretched L6 myoblasts.
Title: Effects of Cyclic Mechanical Stretch on the Proliferation of L6 Myoblasts and Its Mechanisms: PI3K/Akt and MAPK Signal Pathways Regulated by IGF-1 Receptor.
Our results suggested that miR-223 may suppress proliferation of cortical neurons that were treated with oxygen-glucose deprivation and simulated reperfusion via inhibiting IGF1R expression.
Title: miRNA-223 regulates ischemic neuronal injury by targeting the type 1 insulin-like growth factor receptor (IGF1R).

Submit: New GeneRIF Correction See all GeneRIFs (101)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Igf1r (e-PCR), detects polymorphism
- UniSTS:526083

Igf1r (e-PCR), detects polymorphism
- UniSTS:531476

Igf1r (e-PCR), detects polymorphism
- UniSTS:143470

RH135226 (e-PCR)
- UniSTS:218503

BM384925 (e-PCR)
- UniSTS:261258

IGF1R (e-PCR)
- UniSTS:519315

BE111364 (e-PCR)
- UniSTS:245654

GDB:187366 (e-PCR)
- UniSTS:155545

D1Bda23 (e-PCR)
- UniSTS:239770

RH94748 (e-PCR)
- UniSTS:119995

TAMU_PKR0001 (e-PCR)
- UniSTS:513725

TAMU_PKR0002 (e-PCR)
- UniSTS:513725

Igf1r (e-PCR), detects polymorphism
- UniSTS:516547

RH143949 (e-PCR)
- UniSTS:233195

BE119057 (e-PCR)
- UniSTS:249078

Homology

Homologs of the Igf1r gene: The Igf1r gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline: 330 organisms have orthologs with human gene Igf1r
Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
G-protein alpha-subunit binding	IPI Inferred from Physical Interaction more info	PubMed
identical protein binding	IEA Inferred from Electronic Annotation more info
identical protein binding	ISO Inferred from Sequence Orthology more info
insulin binding	IEA Inferred from Electronic Annotation more info
insulin binding	ISO Inferred from Sequence Orthology more info
insulin receptor binding	IEA Inferred from Electronic Annotation more info
insulin receptor binding	ISO Inferred from Sequence Orthology more info
insulin receptor substrate binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
insulin receptor substrate binding	IEA Inferred from Electronic Annotation more info
insulin receptor substrate binding	IPI Inferred from Physical Interaction more info	PubMed
insulin receptor substrate binding	ISO Inferred from Sequence Orthology more info
insulin receptor substrate binding	ISS Inferred from Sequence or Structural Similarity more info
insulin-activated receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
insulin-like growth factor I binding	IEA Inferred from Electronic Annotation more info
insulin-like growth factor I binding	ISO Inferred from Sequence Orthology more info
insulin-like growth factor binding	ISO Inferred from Sequence Orthology more info
insulin-like growth factor binding	ISS Inferred from Sequence or Structural Similarity more info
insulin-like growth factor binding	TAS Traceable Author Statement more info	PubMed
insulin-like growth factor-activated receptor activity	IDA Inferred from Direct Assay more info	PubMed
insulin-like growth factor-activated receptor activity	IEA Inferred from Electronic Annotation more info
insulin-like growth factor-activated receptor activity	ISO Inferred from Sequence Orthology more info
insulin-like growth factor-activated receptor activity	ISS Inferred from Sequence or Structural Similarity more info
insulin-like growth factor-activated receptor activity	TAS Traceable Author Statement more info	PubMed
phosphatidylinositol 3-kinase binding	IEA Inferred from Electronic Annotation more info
phosphatidylinositol 3-kinase binding	ISO Inferred from Sequence Orthology more info
phosphatidylinositol 3-kinase binding	ISS Inferred from Sequence or Structural Similarity more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein transporter activity	IEA Inferred from Electronic Annotation more info
protein transporter activity	ISO Inferred from Sequence Orthology more info
protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
structural molecule activity	ISO Inferred from Sequence Orthology more info
structural molecule activity	ISS Inferred from Sequence or Structural Similarity more info
transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
adrenal gland development	ISO Inferred from Sequence Orthology more info
aging	IEP Inferred from Expression Pattern more info	PubMed
amyloid-beta clearance	IEA Inferred from Electronic Annotation more info
amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
brain development	ISO Inferred from Sequence Orthology more info
cardiac atrium development	IEP Inferred from Expression Pattern more info	PubMed
cellular response to aldosterone	IEP Inferred from Expression Pattern more info	PubMed
cellular response to amyloid-beta	IEA Inferred from Electronic Annotation more info
cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
cellular response to angiotensin	IEP Inferred from Expression Pattern more info	PubMed
cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
cellular response to estradiol stimulus	IEP Inferred from Expression Pattern more info	PubMed
cellular response to glucose stimulus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
cellular response to insulin-like growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
cellular response to insulin-like growth factor stimulus	IPI Inferred from Physical Interaction more info	PubMed
cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
cellular response to progesterone stimulus	IEP Inferred from Expression Pattern more info	PubMed
cellular response to testosterone stimulus	IEP Inferred from Expression Pattern more info	PubMed
cellular response to transforming growth factor beta stimulus	IPI Inferred from Physical Interaction more info	PubMed
cellular senescence	IEP Inferred from Expression Pattern more info	PubMed
cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
cerebellum development	IMP Inferred from Mutant Phenotype more info	PubMed
dendritic spine maintenance	IGI Inferred from Genetic Interaction more info	PubMed
epidermis development	ISO Inferred from Sequence Orthology more info
establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
estrous cycle	IMP Inferred from Mutant Phenotype more info	PubMed
exocrine pancreas development	ISO Inferred from Sequence Orthology more info
glucose homeostasis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
immune response	IEA Inferred from Electronic Annotation more info
immune response	ISO Inferred from Sequence Orthology more info
inactivation of MAPKK activity	IEA Inferred from Electronic Annotation more info
inactivation of MAPKK activity	ISO Inferred from Sequence Orthology more info
inactivation of MAPKK activity	ISS Inferred from Sequence or Structural Similarity more info
insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
insulin-like growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
male sex determination	ISO Inferred from Sequence Orthology more info
mammary gland development	ISO Inferred from Sequence Orthology more info
multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
negative regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of cholangiocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of hepatocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of protein kinase B signaling	ISO Inferred from Sequence Orthology more info
neuron projection development	IDA Inferred from Direct Assay more info	PubMed
peptidyl-tyrosine autophosphorylation	IEA Inferred from Electronic Annotation more info
peptidyl-tyrosine autophosphorylation	ISO Inferred from Sequence Orthology more info
phosphatidylinositol-mediated signaling	IEA Inferred from Electronic Annotation more info
phosphatidylinositol-mediated signaling	ISO Inferred from Sequence Orthology more info
positive regulation of DNA metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
positive regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
positive regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of developmental growth	ISO Inferred from Sequence Orthology more info
positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of meiotic cell cycle	ISO Inferred from Sequence Orthology more info
positive regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
positive regulation of osteoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of phosphatidylinositol 3-kinase signaling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of phosphatidylinositol 3-kinase signaling	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of protein kinase B signaling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of protein kinase B signaling	ISO Inferred from Sequence Orthology more info
positive regulation of protein-containing complex disassembly	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of steroid hormone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription, DNA-templated	ISO Inferred from Sequence Orthology more info
prostate gland epithelium morphogenesis	ISO Inferred from Sequence Orthology more info
protein autophosphorylation	ISO Inferred from Sequence Orthology more info
protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
protein phosphorylation	ISO Inferred from Sequence Orthology more info
regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info	PubMed
regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
response to L-glutamate	IDA Inferred from Direct Assay more info	PubMed
response to ethanol	IDA Inferred from Direct Assay more info	PubMed
response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
response to insulin	IEP Inferred from Expression Pattern more info	PubMed
response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
response to vitamin E	IEP Inferred from Expression Pattern more info	PubMed
transcytosis	IEA Inferred from Electronic Annotation more info
transcytosis	ISO Inferred from Sequence Orthology more info
transmembrane receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
T-tubule	IDA Inferred from Direct Assay more info	PubMed
T-tubule	ISO Inferred from Sequence Orthology more info
alphav-beta3 integrin-IGF-1-IGF1R complex	IEA Inferred from Electronic Annotation more info
alphav-beta3 integrin-IGF-1-IGF1R complex	ISO Inferred from Sequence Orthology more info
axon	IBA Inferred from Biological aspect of Ancestor more info	PubMed
axon	IDA Inferred from Direct Assay more info	PubMed
caveola	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
insulin receptor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
integral component of membrane	IEA Inferred from Electronic Annotation more info
integral component of membrane	ISO Inferred from Sequence Orthology more info
integral component of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
membrane	ISO Inferred from Sequence Orthology more info
neuron projection	IDA Inferred from Direct Assay more info	PubMed
neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	ISO Inferred from Sequence Orthology more info
protein kinase complex	IEA Inferred from Electronic Annotation more info
protein kinase complex	ISO Inferred from Sequence Orthology more info
receptor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
receptor complex	IEA Inferred from Electronic Annotation more info
receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: insulin-like growth factor 1 receptor

Names: IGF-I receptor; insulin-like growth factor I receptor; type-I IGF receptor

NP_434694.1

EC 2.7.10.1

XP_006229386.1

EC 2.7.10.1

XP_008757722.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_052807.2 → NP_434694.1 insulin-like growth factor 1 receptor precursor

See identical proteins and their annotated locations for NP_434694.1

Status: VALIDATED

Source sequence(s)

AABR07004180, AABR07004181, AABR07004182

UniProtKB/Swiss-Prot

P24062

Related

ENSRNOP00000019267.6, ENSRNOT00000019267.6

Conserved Domains (7) summary

cd05032
Location:993 → 1269

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:836 → 925

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00064
Location:230 → 277

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:175 → 330

Furin-like; Furin-like cysteine rich region

pfam01030
Location:353 → 467

Recep_L_domain; Receptor L domain

pfam07714
Location:1000 → 1264

Pkinase_Tyr; Protein tyrosine kinase

cl22855
Location:207 → 336

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

NC_005100.4 Reference Rnor_6.0 Primary Assembly

Range

128924921..129213816

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006229324.2 → XP_006229386.1 insulin-like growth factor 1 receptor isoform X2

See identical proteins and their annotated locations for XP_006229386.1

Conserved Domains (7) summary

cd05032
Location:993 → 1270

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:836 → 925

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00064
Location:230 → 277

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:175 → 330

Furin-like; Furin-like cysteine rich region

pfam01030
Location:353 → 467

Recep_L_domain; Receptor L domain

pfam07714
Location:1000 → 1265

Pkinase_Tyr; Protein tyrosine kinase

cl22855
Location:207 → 336

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
XM_008759500.1 → XP_008757722.1 insulin-like growth factor 1 receptor isoform X1

Conserved Domains (7) summary

cd05032
Location:994 → 1271

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:837 → 926

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00064
Location:230 → 277

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:175 → 330

Furin-like; Furin-like cysteine rich region

pfam01030
Location:353 → 467

Recep_L_domain; Receptor L domain

pfam07714
Location:1001 → 1266

Pkinase_Tyr; Protein tyrosine kinase

cl22855
Location:207 → 336

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)