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Igf1r insulin-like growth factor 1 receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 25718, updated on 6-Jun-2024

Summary

Official Symbol
Igf1rprovided by RGD
Official Full Name
insulin-like growth factor 1 receptorprovided by RGD
Primary source
RGD:2869
See related
Ensembl:ENSRNOG00000014187 AllianceGenome:RGD:2869
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Igfr1; JTK13; IGFIRC; IGF-1 receptor
Summary
Enables G-protein alpha-subunit binding activity; insulin receptor substrate binding activity; and insulin-like growth factor-activated receptor activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of apoptotic process; and nervous system development. Located in several cellular components, including T-tubule; caveola; and neuronal cell body. Used to study Alzheimer's disease; Parkinson's disease; and prostate adenocarcinoma. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); cryptorchidism; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney cancer (multiple); liver disease (multiple); and nervous system cancer (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 154.5), Kidney (RPKM 119.0) and 9 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See Igf1r in Genome Data Viewer
Location:
1q22
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (130959787..131248664)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (121549831..121838548)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (128924921..129213816)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484899 Neighboring gene thymosin beta 10 like 5 Neighboring gene uncharacterized LOC134483685 Neighboring gene pyroglutamyl-peptidase I-like Neighboring gene family with sequence similarity 169, member B Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC102551020 Neighboring gene uncharacterized LOC120099846

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables G-protein alpha-subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin binding IEA
Inferred from Electronic Annotation
more info
 
enables insulin binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables insulin receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin receptor substrate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables insulin receptor substrate binding IEA
Inferred from Electronic Annotation
more info
 
enables insulin receptor substrate binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables insulin receptor substrate binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin receptor substrate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables insulin-like growth factor I binding IEA
Inferred from Electronic Annotation
more info
 
enables insulin-like growth factor I binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables insulin-like growth factor binding TAS
Traceable Author Statement
more info
PubMed 
enables insulin-like growth factor receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables insulin-like growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables insulin-like growth factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables insulin-like growth factor receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol 3-kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables protein transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables structural molecule activity ISO
Inferred from Sequence Orthology
more info
 
enables structural molecule activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
acts_upstream_of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in adrenal gland development ISO
Inferred from Sequence Orthology
more info
 
involved_in amyloid-beta clearance IEA
Inferred from Electronic Annotation
more info
 
involved_in amyloid-beta clearance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within brain development ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac atrium development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to aldosterone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to amyloid-beta IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to angiotensin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to dexamethasone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to estradiol stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to glucose stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin-like growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to insulin-like growth factor stimulus IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to progesterone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to testosterone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to transforming growth factor beta stimulus IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in cellular response to zinc ion starvation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular senescence IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cerebellum development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cerebellum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendritic spine maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within epidermis development ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in estrous cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within exocrine pancreas development ISO
Inferred from Sequence Orthology
more info
 
involved_in hippocampus development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin-like growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within male sex determination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mammary gland development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cholangiocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of hepatocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of developmental growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of meiotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein-containing complex disassembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of steroid hormone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within prostate gland epithelium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to L-glutamate IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to alkaloid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to insulin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to vitamin E IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in transcytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in transcytosis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
part_of alphav-beta3 integrin-IGF-1-IGF1R complex IEA
Inferred from Electronic Annotation
more info
 
part_of alphav-beta3 integrin-IGF-1-IGF1R complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
part_of insulin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 
located_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
part_of protein kinase complex IEA
Inferred from Electronic Annotation
more info
 
part_of protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
insulin-like growth factor 1 receptor
Names
IGF-I receptor
insulin-like growth factor I receptor
type-I IGF receptor
NP_001401110.1
NP_434694.1
XP_008757722.1
XP_038958145.1
XP_038958153.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414181.1NP_001401110.1  insulin-like growth factor 1 receptor isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A140TAB8
  2. NM_052807.3NP_434694.1  insulin-like growth factor 1 receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_434694.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P24062
    UniProtKB/TrEMBL
    A0A140TAB8
    Related
    ENSRNOP00000019267.7, ENSRNOT00000019267.7
    Conserved Domains (7) summary
    cd05032
    Location:9931269
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:836925
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:230277
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:175330
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:353467
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:10001264
    Pkinase_Tyr; Protein tyrosine kinase
    cl22855
    Location:207336
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    130959787..131248664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102225.2XP_038958153.1  insulin-like growth factor 1 receptor isoform X3

    UniProtKB/TrEMBL
    A6JBU5
    Conserved Domains (3) summary
    cd00063
    Location:837926
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:175330
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:353467
    Recep_L_domain; Receptor L domain
  2. XM_039102217.2XP_038958145.1  insulin-like growth factor 1 receptor isoform X2

    UniProtKB/TrEMBL
    A0A140TAB8
    Conserved Domains (4) summary
    cd05032
    Location:9941270
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:837926
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:175330
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:353467
    Recep_L_domain; Receptor L domain
  3. XM_008759500.3XP_008757722.1  insulin-like growth factor 1 receptor isoform X1

    UniProtKB/TrEMBL
    A0A140TAB8
    Conserved Domains (7) summary
    cd05032
    Location:9941271
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:837926
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:230277
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:175330
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:353467
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:10011266
    Pkinase_Tyr; Protein tyrosine kinase
    cl22855
    Location:207336
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)