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Igf1r insulin-like growth factor 1 receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 25718, updated on 18-Jan-2021

Summary

Official Symbol
Igf1rprovided by RGD
Official Full Name
insulin-like growth factor 1 receptorprovided by RGD
Primary source
RGD:2869
See related
Ensembl:ENSRNOG00000014187
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Igfr1; JTK13; IGFIRC; IGF-1 receptor
Summary
receptor for Igf-1; involved in induction of cell cycle progression and survival in many cell types [RGD, Feb 2006]
Expression
Biased expression in Adrenal (RPKM 154.5), Kidney (RPKM 119.0) and 9 other tissues See more
Orthologs
NEW
Try the new Data Table view

Genomic context

See Igf1r in Genome Data Viewer
Location:
1q22
Exon count:
21
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (128924921..129213816)
106 current Rn_Celera (GCF_000002265.2) 1 AC_000069.1 (113751636..114029884)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (129985761..130272589)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556885 Neighboring gene thymosin beta-10 pseudogene Neighboring gene pyroglutamyl-peptidase I-like Neighboring gene family with sequence similarity 169, member B

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
G-protein alpha-subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
insulin binding IEA
Inferred from Electronic Annotation
more info
 
insulin binding ISO
Inferred from Sequence Orthology
more info
 
insulin receptor binding IEA
Inferred from Electronic Annotation
more info
 
insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
insulin receptor substrate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin receptor substrate binding IEA
Inferred from Electronic Annotation
more info
 
insulin receptor substrate binding IPI
Inferred from Physical Interaction
more info
PubMed 
insulin receptor substrate binding ISO
Inferred from Sequence Orthology
more info
 
insulin receptor substrate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
insulin-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-like growth factor I binding IEA
Inferred from Electronic Annotation
more info
 
insulin-like growth factor I binding ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor binding ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
insulin-like growth factor binding TAS
Traceable Author Statement
more info
PubMed 
insulin-like growth factor-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
insulin-like growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
insulin-like growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor-activated receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
insulin-like growth factor-activated receptor activity TAS
Traceable Author Statement
more info
PubMed 
phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol 3-kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein transporter activity IEA
Inferred from Electronic Annotation
more info
 
protein transporter activity ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
structural molecule activity ISO
Inferred from Sequence Orthology
more info
 
structural molecule activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
adrenal gland development ISO
Inferred from Sequence Orthology
more info
 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
amyloid-beta clearance IEA
Inferred from Electronic Annotation
more info
 
amyloid-beta clearance ISO
Inferred from Sequence Orthology
more info
 
animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
brain development ISO
Inferred from Sequence Orthology
more info
 
cardiac atrium development IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to aldosterone IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to amyloid-beta IEA
Inferred from Electronic Annotation
more info
 
cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
cellular response to angiotensin IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to dexamethasone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to estradiol stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to glucose stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to insulin-like growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to insulin-like growth factor stimulus IPI
Inferred from Physical Interaction
more info
PubMed 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to progesterone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to testosterone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to transforming growth factor beta stimulus IPI
Inferred from Physical Interaction
more info
PubMed 
cellular senescence IEP
Inferred from Expression Pattern
more info
PubMed 
cerebellum development IEP
Inferred from Expression Pattern
more info
PubMed 
cerebellum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendritic spine maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
epidermis development ISO
Inferred from Sequence Orthology
more info
 
establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
estrous cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
exocrine pancreas development ISO
Inferred from Sequence Orthology
more info
 
glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hippocampus development IEP
Inferred from Expression Pattern
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
immune response ISO
Inferred from Sequence Orthology
more info
 
inactivation of MAPKK activity IEA
Inferred from Electronic Annotation
more info
 
inactivation of MAPKK activity ISO
Inferred from Sequence Orthology
more info
 
inactivation of MAPKK activity ISS
Inferred from Sequence or Structural Similarity
more info
 
insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
insulin-like growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
male sex determination ISO
Inferred from Sequence Orthology
more info
 
mammary gland development ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cholangiocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of hepatocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of developmental growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of meiotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
positive regulation of osteoblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase B signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein-containing complex disassembly IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of steroid hormone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
prostate gland epithelium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
response to L-glutamate IDA
Inferred from Direct Assay
more info
PubMed 
response to ethanol IDA
Inferred from Direct Assay
more info
PubMed 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to insulin IEP
Inferred from Expression Pattern
more info
PubMed 
response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
response to vitamin E IEP
Inferred from Expression Pattern
more info
PubMed 
transcytosis IEA
Inferred from Electronic Annotation
more info
 
transcytosis ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
T-tubule ISO
Inferred from Sequence Orthology
more info
 
alphav-beta3 integrin-IGF-1-IGF1R complex IEA
Inferred from Electronic Annotation
more info
 
alphav-beta3 integrin-IGF-1-IGF1R complex ISO
Inferred from Sequence Orthology
more info
 
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon IDA
Inferred from Direct Assay
more info
PubMed 
caveola IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
insulin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein kinase complex IEA
Inferred from Electronic Annotation
more info
 
protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex IEA
Inferred from Electronic Annotation
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
insulin-like growth factor 1 receptor
Names
IGF-I receptor
insulin-like growth factor I receptor
type-I IGF receptor
NP_434694.1
XP_006229386.1
XP_008757722.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Data Table view

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052807.2NP_434694.1  insulin-like growth factor 1 receptor precursor

    See identical proteins and their annotated locations for NP_434694.1

    Status: VALIDATED

    Source sequence(s)
    AABR07004180, AABR07004181, AABR07004182
    UniProtKB/Swiss-Prot
    P24062
    Related
    ENSRNOP00000019267.6, ENSRNOT00000019267.6
    Conserved Domains (7) summary
    cd05032
    Location:9931269
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:836925
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:230277
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:175330
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:353467
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:10001264
    Pkinase_Tyr; Protein tyrosine kinase
    cl22855
    Location:207336
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    128924921..129213816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229324.2XP_006229386.1  insulin-like growth factor 1 receptor isoform X2

    See identical proteins and their annotated locations for XP_006229386.1

    Conserved Domains (7) summary
    cd05032
    Location:9931270
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:836925
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:230277
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:175330
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:353467
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:10001265
    Pkinase_Tyr; Protein tyrosine kinase
    cl22855
    Location:207336
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  2. XM_008759500.1XP_008757722.1  insulin-like growth factor 1 receptor isoform X1

    Conserved Domains (7) summary
    cd05032
    Location:9941271
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:837926
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:230277
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:175330
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:353467
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:10011266
    Pkinase_Tyr; Protein tyrosine kinase
    cl22855
    Location:207336
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    113751636..114029884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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