Tgfb3 transforming growth factor, beta 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tgfb3provided by RGD
Official Full Name: transforming growth factor, beta 3provided by RGD
Primary source: RGD:3851
See related: Ensembl:ENSRNOG00000009867 AllianceGenome:RGD:3851
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TGF-B3
Summary: Predicted to enable several functions, including cytokine activity; transforming growth factor beta binding activity; and transforming growth factor beta receptor binding activity. Involved in several processes, including regulation of signal transduction; response to estrogen; and skeletal system morphogenesis. Located in several cellular components, including T-tubule; neuronal cell body; and secretory granule. Biomarker of diabetic neuropathy. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 5; arrhythmogenic right ventricular cardiomyopathy; and arrhythmogenic right ventricular dysplasia 1. Orthologous to human TGFB3 (transforming growth factor beta 3). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Heart (RPKM 174.2), Muscle (RPKM 94.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q31

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (111435170..111457646, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (105704058..105726661, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (109913757..109936217, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GMFB/AKT/TGF-beta3 in Muller cells mediated early retinal degeneration in a streptozotocin-induced rat diabetes model.
Title: GMFB/AKT/TGF-β3 in Müller cells mediated early retinal degeneration in a streptozotocin-induced rat diabetes model.
Maternal Perinatal Exposure to Dibutyl Phthalate Promotes Ovarian Dysfunction in Adult Female Offspring via Downregulation of TGF-beta2 and TGF-beta3.
Title: Maternal Perinatal Exposure to Dibutyl Phthalate Promotes Ovarian Dysfunction in Adult Female Offspring via Downregulation of TGF-β2 and TGF-β3.
Gait analysis combined with the expression of TGF-beta1, TGF-beta3 and CREB during Achilles tendon healing in rat.
Title: Gait analysis combined with the expression of TGF-β1, TGF-β3 and CREB during Achilles tendon healing in rat.
TGF-beta3 regulates adhesion formation through the JNK/c-Jun pathway during flexor tendon healing.
Title: TGF-β3 regulates adhesion formation through the JNK/c-Jun pathway during flexor tendon healing.
down-regulation of miR-140-3p can inhibit painful tactile stimulation of rat pups by inhibiting TGF-beta
Title: Down-regulation of miR-140-3p can alleviate neonatal repetitive pain in rats via inhibiting TGF-β3.
These results indicated that Dental Follicle Stem Cells can reprogram macrophages into the anti-inflammatory M2 phenotype, the paracrine factors TGF-B3 and TSP-1 may be one of the underlying mechanisms.
Title: Dental Follicle Stem Cells Ameliorate Lipopolysaccharide-Induced Inflammation by Secreting TGF-β3 and TSP-1 to Elicit Macrophage M2 Polarization.
TGF-beta3 provided fibroblastic morphology to chondrocytes and therefore overall reduction in cell proliferation was observed. The length of the cells supplemented with TGF-beta3 were larger than the cells without TGF-beta3 treatment.
Title: Effect of transforming growth factor-β3 on mono and multilayer chondrocytes.
structural changes in site-specific airways, along with the temporal and spatial expression of transforming growth factor (TGF)-beta in the lungs of male spontaneously hypertensive rats exposed to tobacco smoke, were characterized.
Title: Temporal and Spatial Expression of Transforming Growth Factor-β after Airway Remodeling to Tobacco Smoke in Rats.
Reorganization of cell junctions and beta-catenin signaling contribute to phagocytosis downstream of TGF-beta3.
Title: Mammary epithelial cell phagocytosis downstream of TGF-β3 is characterized by adherens junction reorganization.
Results suggest that TGF-beta (specifically TGF-beta3) induced CHSY1 expression in the nucleus pulposus through the activation of MAPK signaling.
Title: TGF-β Induces Up-Regulation of Chondroitin Sulfate Synthase 1 (CHSY1) in Nucleus Pulposus Cells Through MAPK Signaling.

Submit: New GeneRIF Correction See all GeneRIFs (40)

General gene information

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Markers

RH94855 (e-PCR)
- UniSTS:120101

Tgfb3 (e-PCR), detects polymorphism
- UniSTS:536425

PMC135637P1 (e-PCR)
- UniSTS:270762

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables transforming growth factor beta binding	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta binding	ISS Inferred from Sequence or Structural Similarity more info
enables transforming growth factor beta receptor binding	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor binding	TAS Traceable Author Statement more info	PubMed
enables type I transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info
enables type I transforming growth factor beta receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables type II transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info
enables type II transforming growth factor beta receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables type III transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info
enables type III transforming growth factor beta receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell-cell junction organization	ISO Inferred from Sequence Orthology more info
involved_in cell-cell junction organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in detection of hypoxia	ISO Inferred from Sequence Orthology more info
involved_in detection of hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in digestive tract development	IEA Inferred from Electronic Annotation more info
involved_in digestive tract development	IEP Inferred from Expression Pattern more info	PubMed
involved_in embryonic neurocranium morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in face morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in face morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in female pregnancy	IEA Inferred from Electronic Annotation more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in frontal suture morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in frontal suture morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within_positive_effect gene expression	ISO Inferred from Sequence Orthology more info
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in inner ear development	IEA Inferred from Electronic Annotation more info
involved_in inner ear development	IEP Inferred from Expression Pattern more info	PubMed
involved_in lung alveolus development	ISO Inferred from Sequence Orthology more info
involved_in lung development	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within mammary gland development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage cytokine production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tight junction disassembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of endothelial cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of epithelial cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of epithelial cell proliferation	TAS Traceable Author Statement more info	PubMed
NOT involved_in regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to laminar fluid shear stress	IEA Inferred from Electronic Annotation more info
involved_in response to laminar fluid shear stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	ISO Inferred from Sequence Orthology more info
involved_in response to progesterone	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within roof of mouth development	ISO Inferred from Sequence Orthology more info
involved_in salivary gland morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in salivary gland morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in secondary palate development	ISO Inferred from Sequence Orthology more info
involved_in secondary palate development	ISS Inferred from Sequence or Structural Similarity more info
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transforming growth factor beta-3 proprotein

Names: TGF-beta-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013174.2 → NP_037306.1 transforming growth factor beta-3 proprotein preproprotein

See identical proteins and their annotated locations for NP_037306.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q07258, Q56A31

UniProtKB/TrEMBL

A6JE51

Related

ENSRNOP00000013516.3, ENSRNOT00000013516.7

Conserved Domains (2) summary

cd19386
Location:312 → 412

TGF_beta_TGFB3; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-3 (TGF-beta-3) and similar proteins

pfam00688
Location:24 → 230

TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

111435170..111457646 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240366.3 → XP_006240428.1 transforming growth factor beta-3 proprotein isoform X1

Conserved Domains (2) summary

cd19386
Location:230 → 330

TGF_beta_TGFB3; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-3 (TGF-beta-3) and similar proteins

cl02928
Location:2 → 148

TGFb_propeptide; TGF-beta propeptide