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RNF214 ring finger protein 214 [ Homo sapiens (human) ]

Gene ID: 257160, updated on 13-Mar-2020

Summary

Official Symbol
RNF214provided by HGNC
Official Full Name
ring finger protein 214provided by HGNC
Primary source
HGNC:HGNC:25335
See related
Ensembl:ENSG00000167257
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 13.2), thyroid (RPKM 7.5) and 25 other tissues See more
Orthologs

Genomic context

See RNF214 in Genome Data Viewer
Location:
11q23.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (117232671..117286454)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (117103341..117156404)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100652768 Neighboring gene SID1 transmembrane family member 2 Neighboring gene transgelin Neighboring gene proprotein convertase subtilisin/kexin type 7 Neighboring gene BACE1 antisense RNA Neighboring gene beta-secretase 1 Neighboring gene centrosomal protein 164 Neighboring gene proline rich 13 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genetic determinants of cardiovascular events among women with migraine: a genome-wide association study.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ring finger protein 214 (RNF214) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp547C195

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077239.1NP_001070707.1  RING finger protein 214 isoform 1

    See identical proteins and their annotated locations for NP_001070707.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same isoform (1).
    Source sequence(s)
    AP000892, BC064581, CN395747
    Consensus CDS
    CCDS41720.1
    UniProtKB/Swiss-Prot
    Q8ND24
    UniProtKB/TrEMBL
    A0A024R3D4
    Related
    ENSP00000431643.1, ENST00000531452.5
    Conserved Domains (1) summary
    pfam13639
    Location:654699
    zf-RING_2; Ring finger domain
  2. NM_001278249.1NP_001265178.1  RING finger protein 214 isoform 2

    See identical proteins and their annotated locations for NP_001265178.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK300160, AL834448
    Consensus CDS
    CCDS60976.1
    UniProtKB/Swiss-Prot
    Q8ND24
    Related
    ENSP00000435361.1, ENST00000531287.5
    Conserved Domains (1) summary
    pfam13639
    Location:499544
    zf-RING_2; Ring finger domain
  3. NM_207343.4NP_997226.2  RING finger protein 214 isoform 1

    See identical proteins and their annotated locations for NP_997226.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK298923, AP000892, BX111206, DC423629
    Consensus CDS
    CCDS41720.1
    UniProtKB/Swiss-Prot
    Q8ND24
    UniProtKB/TrEMBL
    A0A024R3D4
    Related
    ENSP00000300650.4, ENST00000300650.9
    Conserved Domains (1) summary
    pfam13639
    Location:654699
    zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    117232671..117286454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001747824.2 RNA Sequence

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