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Syt1 synaptotagmin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25716, updated on 22-May-2022

Summary

Official Symbol
Syt1provided by RGD
Official Full Name
synaptotagmin 1provided by RGD
Primary source
RGD:3803
See related
Ensembl:ENSRNOG00000006426 AllianceGenome:RGD:3803
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
P65
Summary
Enables several functions, including calmodulin binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in several processes, including positive regulation of dopamine secretion; regulation of vesicle-mediated transport; and response to calcium ion. Located in several cellular components, including excitatory synapse; neuron projection terminus; and secretory vesicle. Is active in hippocampal mossy fiber to CA3 synapse. Is integral component of synaptic vesicle membrane. Biomarker of visual epilepsy. Orthologous to human SYT1 (synaptotagmin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 991.0) See more
Orthologs
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Genomic context

See Syt1 in Genome Data Viewer
Location:
7q21
Exon count:
12
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (43813204..44358020, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (50084063..50638996, complement)

Chromosome 7 - NC_051342.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L26-like Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC120093582 Neighboring gene pro-apoptotic WT1 regulator Neighboring gene uncharacterized LOC120093799 Neighboring gene uncharacterized LOC102547595 Neighboring gene lys-63-specific deubiquitinase BRCC36-like Neighboring gene uncharacterized LOC108351599 Neighboring gene 60S ribosomal protein L31-like Neighboring gene uncharacterized LOC120093800 Neighboring gene similar to histone deacetylase 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SNARE binding IDA
Inferred from Direct Assay
more info
PubMed 
enables SNARE binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
enables calcium ion sensor activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables clathrin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylserine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables syntaxin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables syntaxin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables syntaxin-1 binding IDA
Inferred from Direct Assay
more info
PubMed 
enables syntaxin-1 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables syntaxin-1 binding ISO
Inferred from Sequence Orthology
more info
 
enables syntaxin-3 binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in brain development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in calcium ion-regulated exocytosis of neurotransmitter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within calcium ion-regulated exocytosis of neurotransmitter ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium-dependent activation of synaptic vesicle fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium-ion regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium-ion regulated exocytosis TAS
Traceable Author Statement
more info
PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to calcium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in detection of calcium ion IC
Inferred by Curator
more info
PubMed 
involved_in detection of calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fast, calcium ion-dependent exocytosis of neurotransmitter ISO
Inferred from Sequence Orthology
more info
 
involved_in fast, calcium ion-dependent exocytosis of neurotransmitter ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion-dependent exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of calcium ion-dependent exocytosis of neurotransmitter ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion-dependent exocytosis of neurotransmitter ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dopamine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of vesicle fusion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein heterooligomerization IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of calcium ion-dependent exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of dopamine secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of dopamine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of regulated secretory pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic transmission, glutamatergic ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within spontaneous neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle exocytosis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within synchronous neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle docking IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in chromaffin granule membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
is_active_in dense core granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dense core granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in dense core granule ISO
Inferred from Sequence Orthology
more info
 
located_in excitatory synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in hippocampal mossy fiber to CA3 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular organelle IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection terminus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle membrane TAS
Traceable Author Statement
more info
PubMed 
located_in terminal bouton HDA PubMed 

General protein information

Preferred Names
synaptotagmin-1
Names
synaptotagmin I
sytI

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033680.2NP_001028852.2  synaptotagmin-1

    See identical proteins and their annotated locations for NP_001028852.2

    Status: VALIDATED

    Source sequence(s)
    AA924659, AJ617621, CB615786, CB731032, CO398869
    UniProtKB/Swiss-Prot
    P21707
    UniProtKB/TrEMBL
    Q707P0
    Related
    ENSRNOP00000049624.2, ENSRNOT00000048880.3
    Conserved Domains (3) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
    cd21963
    Location:5112
    Syt1_N; N-terminal domain of synaptotagmin-1 (Syt1) and similar proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051342.1 Reference mRatBN7.2 Primary Assembly

    Range
    43813204..44358020 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765353.3XP_008763575.2  synaptotagmin-1 isoform X2

    Conserved Domains (3) summary
    cd08385
    Location:139261
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:270405
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
    cd21963
    Location:5112
    Syt1_N; N-terminal domain of synaptotagmin-1 (Syt1) and similar proteins
  2. XM_017594679.2XP_017450168.1  synaptotagmin-1 isoform X1

    UniProtKB/Swiss-Prot
    P21707
    Conserved Domains (3) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
    cd21963
    Location:5112
    Syt1_N; N-terminal domain of synaptotagmin-1 (Syt1) and similar proteins
  3. XM_039078497.1XP_038934425.1  synaptotagmin-1 isoform X1

    Conserved Domains (3) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
    cd21963
    Location:5112
    Syt1_N; N-terminal domain of synaptotagmin-1 (Syt1) and similar proteins
  4. XM_039078499.1XP_038934427.1  synaptotagmin-1 isoform X3

    Conserved Domains (2) summary
    cd08385
    Location:33155
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:164299
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1