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PLCXD2 phosphatidylinositol specific phospholipase C X domain containing 2 [ Homo sapiens (human) ]

Gene ID: 257068, updated on 23-Nov-2021

Summary

Official Symbol
PLCXD2provided by HGNC
Official Full Name
phosphatidylinositol specific phospholipase C X domain containing 2provided by HGNC
Primary source
HGNC:HGNC:26462
See related
Ensembl:ENSG00000240891 MIM:617015
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in kidney (RPKM 2.6), liver (RPKM 2.6) and 21 other tissues See more
Orthologs
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Genomic context

See PLCXD2 in Genome Data Viewer
Location:
3q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (111674676..111846447)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (111393523..111565294)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene CD96 molecule Neighboring gene zinc finger BED-type containing 2 Neighboring gene NT5C3A pseudogene 2 Neighboring gene PLCXD2 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 10775 Neighboring gene pleckstrin homology like domain family B member 2 Neighboring gene uncharacterized LOC107984087 Neighboring gene uncharacterized LOC105374040 Neighboring gene Sharpr-MPRA regulatory region 1117 Neighboring gene abhydrolase domain containing 10, depalmitoylase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Common genetic variation and performance on standardized cognitive tests.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif upregulates the expression of phosphatidylinositol-specific phospholipase C, X domain containing 2 (PLCXD2) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: PHLDB2

Homology

Clone Names

  • FLJ31579

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphoric diester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
PI-PLC X domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185106.1NP_001172035.1  PI-PLC X domain-containing protein 2 isoform a

    See identical proteins and their annotated locations for NP_001172035.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC117509, AK056141, BC121155
    Consensus CDS
    CCDS54619.1
    UniProtKB/Swiss-Prot
    Q0VAA5
    Related
    ENSP00000420686.1, ENST00000477665.2
    Conserved Domains (1) summary
    cd08616
    Location:39291
    PI-PLCXD1c; Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1
  2. NM_153268.3NP_695000.1  PI-PLC X domain-containing protein 2 isoform b

    See identical proteins and their annotated locations for NP_695000.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC117509, AK056141
    Consensus CDS
    CCDS2961.1
    UniProtKB/Swiss-Prot
    Q0VAA5
    Related
    ENSP00000377511.3, ENST00000393934.7
    Conserved Domains (1) summary
    cd08616
    Location:39289
    PI-PLCXD1c; Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    111674676..111846447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001134478.1: Suppressed sequence

    Description
    NM_001134478.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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