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Il2ra interleukin 2 receptor subunit alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 25704, updated on 26-Aug-2018

Summary

Official Symbol
Il2raprovided by RGD
Official Full Name
interleukin 2 receptor subunit alphaprovided by RGD
Primary source
RGD:2895
See related
Ensembl:ENSRNOG00000047647
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IL2RAC
Summary
alpha chain of the interleukin 2 receptor; human homolog homodimerizes to form low affinity receptor [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 88.7), Spleen (RPKM 13.6) and 1 other tissue See more
Orthologs

Genomic context

See Il2ra in Genome Data Viewer
Location:
17q12.2
Exon count:
8
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (70500672..70547929, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (72204467..72250556, complement)

Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene F-box DNA helicase 1 Neighboring gene interleukin 15 receptor subunit alpha Neighboring gene 26S protease regulatory subunit 10B-like Neighboring gene RNA binding motif protein 17 Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
interleukin-2 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-2 binding ISO
Inferred from Sequence Orthology
more info
 
interleukin-2 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-2 receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
interleukin-2 receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
T cell homeostasis ISO
Inferred from Sequence Orthology
more info
 
activation-induced cell death of T cells IEA
Inferred from Electronic Annotation
more info
 
activation-induced cell death of T cells ISO
Inferred from Sequence Orthology
more info
 
inflammatory response to antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-2-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of lymphocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of activated T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of T cell homeostatic proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of T cell homeostatic proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of T cell tolerance induction IEA
Inferred from Electronic Annotation
more info
 
regulation of T cell tolerance induction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
interleukin-2 receptor subunit alpha
Names
IL-2 receptor alpha subunit
IL-2 receptor subunit alpha
IL-2-RA
IL-2R subunit alpha
IL2-RA
interleukin 2 receptor, alpha chain

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013163.1NP_037295.1  interleukin-2 receptor subunit alpha precursor

    See identical proteins and their annotated locations for NP_037295.1

    Status: PROVISIONAL

    Source sequence(s)
    M55049
    UniProtKB/Swiss-Prot
    P26897
    Related
    ENSRNOP00000066383.1, ENSRNOT00000073144.2

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

    Range
    70500672..70547929 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000085.1 Alternate Rn_Celera

    Range
    66355852..66402955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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