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SUN3 Sad1 and UNC84 domain containing 3 [ Homo sapiens (human) ]

Gene ID: 256979, updated on 13-May-2022

Summary

Official Symbol
SUN3provided by HGNC
Official Full Name
Sad1 and UNC84 domain containing 3provided by HGNC
Primary source
HGNC:HGNC:22429
See related
Ensembl:ENSG00000164744 MIM:618984; AllianceGenome:HGNC:22429
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SUNC1
Summary
Predicted to enable protein-membrane adaptor activity. Predicted to be involved in nuclear envelope organization. Predicted to be integral component of nuclear inner membrane. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 18.0) See more
Orthologs
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Genomic context

See SUN3 in Genome Data Viewer
Location:
7p12.3
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (47987148..48035902, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (48149392..48191349, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (48026745..48068704, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene polycystin 1 like 1, transient receptor potential channel interacting Neighboring gene Sharpr-MPRA regulatory region 8949 Neighboring gene Sharpr-MPRA regulatory region 5513 Neighboring gene uncharacterized LOC105375270 Neighboring gene HUS1 checkpoint clamp component Neighboring gene chromosome 7 open reading frame 57 Neighboring gene uncharacterized LOC105375271 Neighboring gene uridine phosphorylase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33329

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein-membrane adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in nuclear envelope organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
 
part_of meiotic nuclear membrane microtubule tethering complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
SUN domain-containing protein 3
Names
Sad1 and UNC84 domain containing 1
hypothetical protein MGC33329
sad1/unc-84 domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030019.2NP_001025190.1  SUN domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001025190.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AF429967, BC026189, BU623138
    Consensus CDS
    CCDS34636.1
    UniProtKB/Swiss-Prot
    Q8TAQ9
    Related
    ENSP00000297325.4, ENST00000297325.9
    Conserved Domains (1) summary
    pfam07738
    Location:219353
    Sad1_UNC; Sad1 / UNC-like C-terminal
  2. NM_001284350.2NP_001271279.1  SUN domain-containing protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and contains an alternate exon in the 5' coding region compared to variant 1. These differences result in the use of a alternate start codon compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC069279, AI222206, AK302011, BI825617
    Consensus CDS
    CCDS64647.1
    UniProtKB/Swiss-Prot
    Q8TAQ9
    Related
    ENSP00000410204.2, ENST00000412142.5
    Conserved Domains (1) summary
    pfam07738
    Location:207341
    Sad1_UNC; Sad1 / UNC-like C-terminal
  3. NM_152782.4NP_689995.3  SUN domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_689995.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC026189, BG772576, BU623138
    Consensus CDS
    CCDS34636.1
    UniProtKB/Swiss-Prot
    Q8TAQ9
    Related
    ENSP00000378939.2, ENST00000395572.6
    Conserved Domains (1) summary
    pfam07738
    Location:219353
    Sad1_UNC; Sad1 / UNC-like C-terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    47987148..48035902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011930.2XP_016867419.1  SUN domain-containing protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q8TAQ9
    Conserved Domains (1) summary
    pfam07738
    Location:219353
    Sad1_UNC; Sad1 / UNC-like C-terminal
  2. XM_047420114.1XP_047276070.1  SUN domain-containing protein 3 isoform X1

  3. XM_047420113.1XP_047276069.1  SUN domain-containing protein 3 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    48149392..48191349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)