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KANK3 KN motif and ankyrin repeat domains 3 [ Homo sapiens (human) ]

Gene ID: 256949, updated on 5-Jan-2022

Summary

Official Symbol
KANK3provided by HGNC
Official Full Name
KN motif and ankyrin repeat domains 3provided by HGNC
Primary source
HGNC:HGNC:24796
See related
Ensembl:ENSG00000186994 MIM:614611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANKRD47
Summary
Predicted to be involved in negative regulation of actin filament polymerization. Predicted to be active in cytoplasm and cytoskeleton. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in fat (RPKM 11.4), spleen (RPKM 8.7) and 21 other tissues See more
Orthologs
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Genomic context

See KANK3 in Genome Data Viewer
Location:
19p13.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (8322584..8343262, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8387468..8408146, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CD320 molecule Neighboring gene NADH:ubiquinone oxidoreductase subunit A7 Neighboring gene ribosomal protein S28 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene angiopoietin like 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ46061

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
KN motif and ankyrin repeat domain-containing protein 3
Names
ankyrin repeat domain 47
ankyrin repeat domain-containing protein 47
kidney ankyrin repeat-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198471.3NP_940873.2  KN motif and ankyrin repeat domain-containing protein 3

    See identical proteins and their annotated locations for NP_940873.2

    Status: VALIDATED

    Source sequence(s)
    BC066124
    Consensus CDS
    CCDS12199.1
    UniProtKB/Swiss-Prot
    Q6NY19
    Related
    ENSP00000328923.2, ENST00000330915.7
    Conserved Domains (5) summary
    PHA03247
    Location:59181
    PHA03247; large tegument protein UL36; Provisional
    COG0666
    Location:617763
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    TIGR03480
    Location:188287
    HpnN; hopanoid biosynthesis associated RND transporter like protein HpnN
    sd00045
    Location:622692
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:3374
    KN_motif; KN motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    8322584..8343262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722718.4XP_006722781.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006722781.1

    UniProtKB/Swiss-Prot
    Q6NY19
    Conserved Domains (5) summary
    PHA03247
    Location:59181
    PHA03247; large tegument protein UL36; Provisional
    COG0666
    Location:617763
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    TIGR03480
    Location:188287
    HpnN; hopanoid biosynthesis associated RND transporter like protein HpnN
    sd00045
    Location:622692
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:3374
    KN_motif; KN motif
  2. XM_011527884.2XP_011526186.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X2

    See identical proteins and their annotated locations for XP_011526186.1

    UniProtKB/Swiss-Prot
    Q6NY19
    Conserved Domains (5) summary
    PHA03247
    Location:59181
    PHA03247; large tegument protein UL36; Provisional
    COG0666
    Location:617763
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    TIGR03480
    Location:188287
    HpnN; hopanoid biosynthesis associated RND transporter like protein HpnN
    sd00045
    Location:622692
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:3374
    KN_motif; KN motif
  3. XM_017026563.2XP_016882052.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X1

RNA

  1. XR_936169.2 RNA Sequence

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