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Plat plasminogen activator, tissue type [ Rattus norvegicus (Norway rat) ]

Gene ID: 25692, updated on 30-Sep-2021

Summary

Symbol
Platprovided by RGD
Full Name
plasminogen activator, tissue typeprovided by RGD
Primary source
RGD:3342
See related
EnsemblRapid:ENSRNOG00000019018
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
tPA; PATISS
Summary
serine protease; catalyzes conversion of inactive proenzyme plasminogen into active serine protease plasmin [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 333.5), Lung (RPKM 332.3) and 9 other tissues See more
Orthologs
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Genomic context

See Plat in Genome Data Viewer
Location:
16q12.5
Exon count:
15
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (69240582..69265177, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (74098263..74122897, complement)

Chromosome 16 - NC_051351.1Genomic Context describing neighboring genes Neighboring gene dynein assembly factor 3, axonemal homolog Neighboring gene uncharacterized LOC120097528 Neighboring gene uncharacterized LOC120097529 Neighboring gene adaptor related protein complex 3 subunit mu 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene inhibitor of nuclear factor kappa B kinase subunit beta

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to dexamethasone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to follicle-stimulating hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to luteinizing hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in plasminogen activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in plasminogen activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in plasminogen activation IEA
Inferred from Electronic Annotation
more info
 
involved_in plasminogen activation ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet-derived growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ovulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in prevention of polyspermy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic plasticity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to cAMP IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to fatty acid IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in smooth muscle cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
NOT located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuronal dense core vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal dense core vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuronal dense core vesicle IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in neuronal dense core vesicle IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in perisynaptic space IDA
Inferred from Direct Assay
more info
PubMed 
located_in perisynaptic space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in perisynaptic space IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in perisynaptic space IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in postsynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tissue-type plasminogen activator
Names
t-PA
t-plasminogen activator
tissue plasminogen activator
tissue-type plasminogen activator-like
NP_037283.2
XP_006253409.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013151.3NP_037283.2  tissue-type plasminogen activator precursor

    See identical proteins and their annotated locations for NP_037283.2

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000283
    UniProtKB/Swiss-Prot
    P19637
    Conserved Domains (3) summary
    cd00108
    Location:210295
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00190
    Location:311556
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00051
    Location:124205
    Kringle; Kringle domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051351.1 Reference mRatBN7.2 Primary Assembly

    Range
    69240582..69265177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253347.4XP_006253409.2  tissue-type plasminogen activator isoform X1

    Related
    ENSRNOP00000025764.4, ENSRNOT00000025763.7
    Conserved Domains (3) summary
    cd00108
    Location:210295
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00190
    Location:311556
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00051
    Location:124205
    Kringle; Kringle domain
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