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Plat plasminogen activator, tissue type [ Rattus norvegicus (Norway rat) ]

Gene ID: 25692, updated on 19-Apr-2019

Summary

Official Symbol
Platprovided by RGD
Official Full Name
plasminogen activator, tissue typeprovided by RGD
Primary source
RGD:3342
See related
Ensembl:ENSRNOG00000019018
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
tPA; PATISS
Summary
serine protease; catalyzes conversion of inactive proenzyme plasminogen into active serine protease plasmin [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 333.5), Lung (RPKM 332.3) and 9 other tissues See more

Genomic context

See Plat in Genome Data Viewer
Location:
16q12.5
Exon count:
16
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (74098263..74122897, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 16 NC_005115.3 (73730256..73754851, complement)

Chromosome 16 - NC_005115.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556951 Neighboring gene adaptor related protein complex 3 subunit mu 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene uncharacterized LOC108348421 Neighboring gene inhibitor of nuclear factor kappa B kinase subunit beta

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
cellular response to dexamethasone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to follicle-stimulating hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to luteinizing hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
PubMed 
plasminogen activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasminogen activation IDA
Inferred from Direct Assay
more info
PubMed 
plasminogen activation ISO
Inferred from Sequence Orthology
more info
PubMed 
platelet-derived growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of ovulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of synaptic plasticity IEP
Inferred from Expression Pattern
more info
PubMed 
response to cAMP IEP
Inferred from Expression Pattern
more info
PubMed 
response to fatty acid IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
PubMed 
smooth muscle cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
trans-synaptic signaling by BDNF, modulating synaptic transmission ISO
Inferred from Sequence Orthology
more info
PubMed 
wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
apical part of cell ISO
Inferred from Sequence Orthology
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
NOT collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
neuronal dense core vesicle EXP
Inferred from Experiment
more info
PubMed 
neuronal dense core vesicle IDA
Inferred from Direct Assay
more info
PubMed 
perisynaptic space EXP
Inferred from Experiment
more info
PubMed 
perisynaptic space IDA
Inferred from Direct Assay
more info
PubMed 
postsynapse EXP
Inferred from Experiment
more info
PubMed 
postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule ISO
Inferred from Sequence Orthology
more info
PubMed 
synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tissue-type plasminogen activator
Names
t-PA
t-plasminogen activator
tissue plasminogen activator
NP_037283.2
XP_006253409.1
XP_008769570.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013151.2NP_037283.2  tissue-type plasminogen activator precursor

    See identical proteins and their annotated locations for NP_037283.2

    Status: PROVISIONAL

    Source sequence(s)
    BC061565
    UniProtKB/Swiss-Prot
    P19637
    Related
    ENSRNOP00000025764.3, ENSRNOT00000025763.6
    Conserved Domains (4) summary
    smart00020
    Location:308553
    Tryp_SPc; Trypsin-like serine protease
    cd00108
    Location:210295
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00190
    Location:311556
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00051
    Location:124205
    Kringle; Kringle domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005115.4 Reference Rnor_6.0 Primary Assembly

    Range
    74098263..74122897 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008771348.1XP_008769570.1  tissue-type plasminogen activator isoform X2

    See identical proteins and their annotated locations for XP_008769570.1

    UniProtKB/Swiss-Prot
    P19637
    Conserved Domains (4) summary
    smart00020
    Location:308553
    Tryp_SPc; Trypsin-like serine protease
    cd00108
    Location:210295
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00190
    Location:311556
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00051
    Location:124205
    Kringle; Kringle domain
  2. XM_006253347.3XP_006253409.1  tissue-type plasminogen activator isoform X1

    Conserved Domains (4) summary
    smart00020
    Location:345590
    Tryp_SPc; Trypsin-like serine protease
    cd00108
    Location:247332
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00190
    Location:348593
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00051
    Location:161242
    Kringle; Kringle domain

Alternate Rn_Celera

Genomic

  1. AC_000084.1 Alternate Rn_Celera

    Range
    67134451..67159047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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