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Htr5a 5-hydroxytryptamine receptor 5A [ Rattus norvegicus (Norway rat) ]

Gene ID: 25689, updated on 12-Jan-2022

Summary

Official Symbol
Htr5aprovided by RGD
Official Full Name
5-hydroxytryptamine receptor 5Aprovided by RGD
Primary source
RGD:2851
See related
Ensembl:ENSRNOG00000007066
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MR22; 5HT5A
Summary
Enables G protein-coupled serotonin receptor activity. Involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; hippocampus development; and response to estradiol. Located in several cellular components, including Golgi apparatus; perikaryon; and rough endoplasmic reticulum. Is integral component of postsynaptic specialization membrane. Orthologous to human HTR5A (5-hydroxytryptamine receptor 5A). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Restricted expression toward (RPKM 30.0) See more
Orthologs
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Genomic context

See Htr5a in Genome Data Viewer
Location:
4q11
Exon count:
2
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (7444968..7454651, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (199916..209599)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546740 Neighboring gene uncharacterized LOC103692012 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene high mobility group protein B1-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled serotonin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables G protein-coupled serotonin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables serotonin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in integral component of postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
located_in rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
5-hydroxytryptamine receptor 5A
Names
5-HT-5A
5-HT5A
5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
REC17
serotonin receptor 5A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013148.2NP_037280.1  5-hydroxytryptamine receptor 5A

    See identical proteins and their annotated locations for NP_037280.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000139
    UniProtKB/Swiss-Prot
    P35364
    Related
    ENSRNOP00000009317.1, ENSRNOT00000009317.3
    Conserved Domains (2) summary
    cd14964
    Location:4268
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:41349
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    7444968..7454651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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