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Ddr1 discoidin domain receptor tyrosine kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25678, updated on 1-May-2017
Official Symbol
Ddr1provided by RGD
Official Full Name
discoidin domain receptor tyrosine kinase 1provided by RGD
Primary source
RGD:2252
See related
Ensembl:ENSRNOG00000057125 Vega:OTTRNOG00000001595
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cak; Drd1; PTK3D
Summary
protein tyrosine kinase that may play a role in nervous system development [RGD, Feb 2006]
Orthologs
Location:
20p12
Exon count:
26
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (3553430..3574959)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (5652154..5671944)

Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553505 Neighboring gene hypothetical LOC100310783 Neighboring gene uncharacterized LOC108349028 Neighboring gene general transcription factor 2H subunit 4 Neighboring gene valyl-tRNA synthetase 2, mitochondrial

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
collagen binding IEA
Inferred from Electronic Annotation
more info
 
collagen binding ISO
Inferred from Sequence Orthology
more info
 
collagen binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
protein tyrosine kinase collagen receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase collagen receptor activity ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase collagen receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
animal organ regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
axon development IEA
Inferred from Electronic Annotation
more info
 
axon development ISO
Inferred from Sequence Orthology
more info
 
branching involved in mammary gland duct morphogenesis IEA
Inferred from Electronic Annotation
more info
 
branching involved in mammary gland duct morphogenesis ISO
Inferred from Sequence Orthology
more info
 
collagen-activated tyrosine kinase receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
collagen-activated tyrosine kinase receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
collagen-activated tyrosine kinase receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
ear development IEA
Inferred from Electronic Annotation
more info
 
ear development ISO
Inferred from Sequence Orthology
more info
 
embryo implantation IEA
Inferred from Electronic Annotation
more info
 
embryo implantation ISO
Inferred from Sequence Orthology
more info
 
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
lactation IEA
Inferred from Electronic Annotation
more info
 
mammary gland alveolus development IEA
Inferred from Electronic Annotation
more info
 
mammary gland alveolus development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
neuron projection extension IEA
Inferred from Electronic Annotation
more info
 
neuron projection extension ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
regulation of cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
regulation of extracellular matrix disassembly IEA
Inferred from Electronic Annotation
more info
 
regulation of extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
 
regulation of extracellular matrix disassembly ISS
Inferred from Sequence or Structural Similarity
more info
 
skin development IEP
Inferred from Expression Pattern
more info
PubMed 
smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
smooth muscle cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
smooth muscle cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
smooth muscle cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
smooth muscle cell-matrix adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
wound healing, spreading of cells IEA
Inferred from Electronic Annotation
more info
 
wound healing, spreading of cells ISO
Inferred from Sequence Orthology
more info
 
wound healing, spreading of cells ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex IEA
Inferred from Electronic Annotation
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
epithelial discoidin domain-containing receptor 1
Names
CD167 antigen-like family member A
cell adhesion kinase
discoidin domain receptor family, member 1
discoidin receptor tyrosine kinase
epithelial discoidin domain receptor 1
neurotrophic tyrosine kinase receptor type 4
protein-tyrosine kinase 3
protein-tyrosine kinase PTK-3
tyrosine kinase DDR
tyrosine-protein kinase CAK
NP_001159494.1
NP_037269.2
XP_017457045.1
XP_017457046.1
XP_017457047.1
XP_017457048.1
XP_017457049.1
XP_017457050.1
XP_017457051.1
XP_017457053.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166022.1NP_001159494.1  epithelial discoidin domain-containing receptor 1 precursor

    See identical proteins and their annotated locations for NP_001159494.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC166604, BX883047, CB613563
    UniProtKB/TrEMBL
    B2GVB6, Q6MG19
    Related
    ENSRNOP00000071475.1, ENSRNOT00000085380.1
    Conserved Domains (4) summary
    cd05096
    Location:601904
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    smart00219
    Location:607902
    TyrKc; Tyrosine kinase, catalytic domain
    smart00231
    Location:31186
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  2. NM_013137.2NP_037269.2  epithelial discoidin domain-containing receptor 1 precursor

    See identical proteins and their annotated locations for NP_037269.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC166604, BX883047, DN935615
    UniProtKB/TrEMBL
    B2GVB6, Q6MG19
    Related
    ENSRNOP00000072556.1, ENSRNOT00000085635.1
    Conserved Domains (4) summary
    cd05096
    Location:601904
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    smart00219
    Location:607902
    TyrKc; Tyrosine kinase, catalytic domain
    smart00231
    Location:31186
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

    Range
    3553430..3574959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017601558.1XP_017457047.1  epithelial discoidin domain-containing receptor 1 isoform X1

    UniProtKB/TrEMBL
    Q6MG19
    Related
    ENSRNOP00000069611.1, OTTRNOP00000001439, ENSRNOT00000083223.1, OTTRNOT00000002510
    Conserved Domains (4) summary
    cd05096
    Location:601904
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    smart00219
    Location:607902
    TyrKc; Tyrosine kinase, catalytic domain
    smart00231
    Location:31186
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  2. XM_017601564.1XP_017457053.1  epithelial discoidin domain-containing receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K7S7
    Related
    ENSRNOP00000074328.1, OTTRNOP00000001440, ENSRNOT00000090080.1, OTTRNOT00000002511
  3. XM_017601556.1XP_017457045.1  epithelial discoidin domain-containing receptor 1 isoform X1

    UniProtKB/TrEMBL
    Q6MG19
    Conserved Domains (4) summary
    cd05096
    Location:601904
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    smart00219
    Location:607902
    TyrKc; Tyrosine kinase, catalytic domain
    smart00231
    Location:31186
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  4. XM_017601559.1XP_017457048.1  epithelial discoidin domain-containing receptor 1 isoform X1

    UniProtKB/TrEMBL
    Q6MG19
    Conserved Domains (4) summary
    cd05096
    Location:601904
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    smart00219
    Location:607902
    TyrKc; Tyrosine kinase, catalytic domain
    smart00231
    Location:31186
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  5. XM_017601560.1XP_017457049.1  epithelial discoidin domain-containing receptor 1 isoform X1

    UniProtKB/TrEMBL
    Q6MG19
    Conserved Domains (4) summary
    cd05096
    Location:601904
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    smart00219
    Location:607902
    TyrKc; Tyrosine kinase, catalytic domain
    smart00231
    Location:31186
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  6. XM_017601561.1XP_017457050.1  epithelial discoidin domain-containing receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K7S7
  7. XM_017601557.1XP_017457046.1  epithelial discoidin domain-containing receptor 1 isoform X1

    UniProtKB/TrEMBL
    Q6MG19
    Conserved Domains (4) summary
    cd05096
    Location:601904
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    smart00219
    Location:607902
    TyrKc; Tyrosine kinase, catalytic domain
    smart00231
    Location:31186
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  8. XM_017601562.1XP_017457051.1  epithelial discoidin domain-containing receptor 1 isoform X3

Alternate Rn_Celera

Genomic

  1. AC_000088.1 Alternate Rn_Celera

    Range
    470029..489383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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