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Anxa5 annexin A5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25673, updated on 18-Nov-2018

Summary

Official Symbol
Anxa5provided by RGD
Official Full Name
annexin A5provided by RGD
Primary source
RGD:2120
See related
Ensembl:ENSRNOG00000014453
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LC5; Anx5
Summary
displays calcium dependent binding to phospholipid membranes [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 1032.8), Heart (RPKM 711.1) and 9 other tissues See more
Orthologs

Genomic context

See Anxa5 in Genome Data Viewer
Location:
2q25
Exon count:
14
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (123162477..123194730, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (142777624..142808420, complement)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene arylsulfatase E Neighboring gene pyroglutamylated RFamide peptide receptor Neighboring gene uncharacterized LOC108349997 Neighboring gene exosome component 9 Neighboring gene cyclin A2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC93655

Gene Ontology Provided by RGD

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent phospholipid binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
calcium-transporting ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-transporting ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide hormone binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ATP hydrolysis coupled cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
blood coagulation IEA
Inferred from Electronic Annotation
more info
 
calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
cellular response to gonadotropin-releasing hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to gonadotropin-releasing hormone IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to lead ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to lead ion IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of blood coagulation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of coagulation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of prolactin secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of prolactin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of sequestering of calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
protein homooligomerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein homooligomerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of flagellated sperm motility IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of flagellated sperm motility IDA
Inferred from Direct Assay
more info
PubMed 
response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
response to organic substance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to organic substance IEA
Inferred from Electronic Annotation
more info
 
response to organic substance ISO
Inferred from Sequence Orthology
more info
 
response to thyroid hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to thyroid hormone IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
Z disc IDA
Inferred from Direct Assay
more info
PubMed 
axon terminus IDA
Inferred from Direct Assay
more info
PubMed 
cell projection IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endothelial microparticle IEA
Inferred from Electronic Annotation
more info
 
endothelial microparticle ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
intercalated disc IDA
Inferred from Direct Assay
more info
PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
annexin A5
Names
Annexin V
CBP-I
PAP-I
PP4
VAC-alpha
anchorin CII
annexin-5
calphobindin I
endonexin II
lipocortin V
placental anticoagulant protein 4
placental anticoagulant protein I
thromboplastin inhibitor
vascular anticoagulant-alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013132.1NP_037264.1  annexin A5

    See identical proteins and their annotated locations for NP_037264.1

    Status: PROVISIONAL

    Source sequence(s)
    M21730
    UniProtKB/Swiss-Prot
    P14668
    Related
    ENSRNOP00000019552.5, ENSRNOT00000019554.6
    Conserved Domains (1) summary
    pfam00191
    Location:1882
    Annexin; Annexin

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    123162477..123194730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590653.1XP_017446142.1  annexin A5 isoform X1

    UniProtKB/TrEMBL
    Q66HH8
    Conserved Domains (1) summary
    pfam00191
    Location:1882
    Annexin; Annexin
  2. XM_017590652.1XP_017446141.1  annexin A5 isoform X1

    UniProtKB/TrEMBL
    Q66HH8
    Conserved Domains (1) summary
    pfam00191
    Location:1882
    Annexin; Annexin
  3. XM_006232268.3XP_006232330.1  annexin A5 isoform X1

    See identical proteins and their annotated locations for XP_006232330.1

    UniProtKB/TrEMBL
    Q66HH8
    Conserved Domains (1) summary
    pfam00191
    Location:1882
    Annexin; Annexin

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    114271560..114302133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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