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MAP7D2 MAP7 domain containing 2 [ Homo sapiens (human) ]

Gene ID: 256714, updated on 4-Oct-2020

Summary

Official Symbol
MAP7D2provided by HGNC
Official Full Name
MAP7 domain containing 2provided by HGNC
Primary source
HGNC:HGNC:25899
See related
Ensembl:ENSG00000184368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 8.5), testis (RPKM 4.5) and 4 other tissues See more
Orthologs

Genomic context

See MAP7D2 in Genome Data Viewer
Location:
Xp22.12
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (20006713..20116907, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (20024831..20135114, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene SH3 domain containing kinase binding protein 1 Neighboring gene BCLAF1 and THRAP3 family member 3 Neighboring gene uncharacterized LOC729609 Neighboring gene microRNA 23c Neighboring gene EIF1AX antisense RNA 1 Neighboring gene small Cajal body-specific RNA 9 like Neighboring gene eukaryotic translation initiation factor 1A X-linked

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14503, MGC104944

Gene Ontology Provided by GOA

Process Evidence Code Pubs
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
MAP7 domain-containing protein 2
Names
MAP7 domain containing 2 brain
MAP7 domain containing 2 protein varaint 1
MAP7 domain containing 2 protein varaint 2
MAP7 domain-containing protein 2 brain specific variant 1
MAP7 domain-containing protein 2 brain specific variant 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016371.1 RefSeqGene

    Range
    5090..115284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001168465.2NP_001161937.1  MAP7 domain-containing protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AW138738, BC089400, BC136379, R45976
    Consensus CDS
    CCDS55386.1
    UniProtKB/Swiss-Prot
    Q96T17
    Related
    ENSP00000368964.5, ENST00000379643.10
    Conserved Domains (2) summary
    pfam05672
    Location:425603
    MAP7; MAP7 (E-MAP-115) family
    cl20817
    Location:53119
    GBP_C; Guanylate-binding protein, C-terminal domain
  2. NM_001168466.2NP_001161938.1  MAP7 domain-containing protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001161938.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AK296319, AW138738, BC089400, R45976
    Consensus CDS
    CCDS55385.1
    UniProtKB/Swiss-Prot
    Q96T17
    Related
    ENSP00000388239.3, ENST00000443379.7
    Conserved Domains (2) summary
    pfam05672
    Location:339510
    MAP7; MAP7 (E-MAP-115) family
    cl20817
    Location:53119
    GBP_C; Guanylate-binding protein, C-terminal domain
  3. NM_001168467.2NP_001161939.1  MAP7 domain-containing protein 2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (4) maintains the reading frame but is shorter, compared to isoform 1.
    Source sequence(s)
    AK294788, AL732366, AW138738, BC089400, DA409284, R45976
    Consensus CDS
    CCDS55384.1
    UniProtKB/Swiss-Prot
    Q96T17
    Related
    ENSP00000413301.3, ENST00000452324.3
    Conserved Domains (2) summary
    pfam05672
    Location:332510
    MAP7; MAP7 (E-MAP-115) family
    cl20817
    Location:975
    GBP_C; Guanylate-binding protein, C-terminal domain
  4. NM_152780.4NP_689993.2  MAP7 domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_689993.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AW138738, BC037165, BC136379, R45976
    Consensus CDS
    CCDS14195.1
    UniProtKB/Swiss-Prot
    Q96T17
    Related
    ENSP00000368972.3, ENST00000379651.7
    Conserved Domains (2) summary
    pfam05672
    Location:384562
    MAP7; MAP7 (E-MAP-115) family
    cl20817
    Location:53119
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    20006713..20116907 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274480.3XP_005274537.1  MAP7 domain-containing protein 2 isoform X10

    Conserved Domains (2) summary
    pfam05672
    Location:376554
    MAP7; MAP7 (E-MAP-115) family
    cl20817
    Location:53119
    GBP_C; Guanylate-binding protein, C-terminal domain
  2. XM_005274479.2XP_005274536.1  MAP7 domain-containing protein 2 isoform X8

    UniProtKB/TrEMBL
    A0A0K1JS24
    Conserved Domains (2) summary
    pfam05672
    Location:398576
    MAP7; MAP7 (E-MAP-115) family
    cl20817
    Location:53119
    GBP_C; Guanylate-binding protein, C-terminal domain
  3. XM_017029393.1XP_016884882.1  MAP7 domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A0M4FLI9
    Conserved Domains (2) summary
    pfam05672
    Location:406584
    MAP7; MAP7 (E-MAP-115) family
    cl20817
    Location:53119
    GBP_C; Guanylate-binding protein, C-terminal domain
  4. XM_011545483.1XP_011543785.1  MAP7 domain-containing protein 2 isoform X2

    Conserved Domains (2) summary
    pfam05672
    Location:447625
    MAP7; MAP7 (E-MAP-115) family
    cl20817
    Location:53119
    GBP_C; Guanylate-binding protein, C-terminal domain
  5. XM_006724482.2XP_006724545.1  MAP7 domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A0M4F6E1
    Conserved Domains (2) summary
    pfam05672
    Location:417595
    MAP7; MAP7 (E-MAP-115) family
    cl20817
    Location:53119
    GBP_C; Guanylate-binding protein, C-terminal domain
  6. XM_006724481.2XP_006724544.1  MAP7 domain-containing protein 2 isoform X1

    Conserved Domains (2) summary
    pfam05672
    Location:458636
    MAP7; MAP7 (E-MAP-115) family
    cl20817
    Location:53119
    GBP_C; Guanylate-binding protein, C-terminal domain
  7. XM_017029394.1XP_016884883.1  MAP7 domain-containing protein 2 isoform X11

  8. XM_011545484.1XP_011543786.1  MAP7 domain-containing protein 2 isoform X4

    Conserved Domains (2) summary
    pfam05672
    Location:414592
    MAP7; MAP7 (E-MAP-115) family
    cl20817
    Location:975
    GBP_C; Guanylate-binding protein, C-terminal domain
  9. XM_024452361.1XP_024308129.1  MAP7 domain-containing protein 2 isoform X9

    Conserved Domains (2) summary
    pfam05672
    Location:381559
    MAP7; MAP7 (E-MAP-115) family
    pfam05914
    Location:175
    RIB43A
  10. XM_017029397.1XP_016884886.1  MAP7 domain-containing protein 2 isoform X14

  11. XM_017029396.1XP_016884885.1  MAP7 domain-containing protein 2 isoform X13

  12. XM_011545485.1XP_011543787.1  MAP7 domain-containing protein 2 isoform X7

    Conserved Domains (2) summary
    pfam05672
    Location:403581
    MAP7; MAP7 (E-MAP-115) family
    cl20817
    Location:975
    GBP_C; Guanylate-binding protein, C-terminal domain
  13. XM_005274478.3XP_005274535.1  MAP7 domain-containing protein 2 isoform X5

    UniProtKB/TrEMBL
    A0A0K1JRJ6
    Conserved Domains (2) summary
    pfam05672
    Location:409587
    MAP7; MAP7 (E-MAP-115) family
    cl20817
    Location:53119
    GBP_C; Guanylate-binding protein, C-terminal domain
  14. XM_017029395.2XP_016884884.1  MAP7 domain-containing protein 2 isoform X12

  15. XM_017029398.2XP_016884887.1  MAP7 domain-containing protein 2 isoform X17

  16. XM_024452362.1XP_024308130.1  MAP7 domain-containing protein 2 isoform X16

    Conserved Domains (2) summary
    pfam05914
    Location:40119
    RIB43A
    cl25742
    Location:425452
    ERM; Ezrin/radixin/moesin family
  17. XM_011545486.3XP_011543788.1  MAP7 domain-containing protein 2 isoform X15

    Conserved Domains (1) summary
    cl20817
    Location:53119
    GBP_C; Guanylate-binding protein, C-terminal domain
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