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Smad1 SMAD family member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25671, updated on 22-Aug-2021

Summary

Official Symbol
Smad1provided by RGD
Official Full Name
SMAD family member 1provided by RGD
Primary source
RGD:3030
See related
Ensembl:ENSRNOG00000018483
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Madh1
Summary
a transcriptional activator; activated by bone morphogenetic protein 4 (BMP4) [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 65.7), Heart (RPKM 64.3) and 9 other tissues See more
Orthologs
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Genomic context

See Smad1 in Genome Data Viewer
Location:
19q11
Exon count:
10
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (28513130..28573665)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (32182942..32248694)

Chromosome 19 - NC_051354.1Genomic Context describing neighboring genes Neighboring gene cytosolic purine 5'-nucleotidase-like Neighboring gene mitochondrial ribosomal protein S36-like Neighboring gene metabolism of cobalamin associated A Neighboring gene uncharacterized LOC102550010 Neighboring gene LOC498933

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DEAD/H-box RNA helicase binding IEA
Inferred from Electronic Annotation
more info
 
enables DEAD/H-box RNA helicase binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables I-SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables I-SMAD binding IEA
Inferred from Electronic Annotation
more info
 
enables I-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables co-SMAD binding IEA
Inferred from Electronic Annotation
more info
 
enables co-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables primary miRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables primary miRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in SMAD protein complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in SMAD protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in bone development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within bone development ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in cartilage development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cartilage development ISO
Inferred from Sequence Orthology
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic pattern specification ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in gamete generation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within gamete generation ISO
Inferred from Sequence Orthology
more info
 
involved_in hindbrain development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within hindbrain development ISO
Inferred from Sequence Orthology
more info
 
involved_in homeostatic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within homeostatic process ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in kidney development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in mesodermal cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mesodermal cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in midbrain development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within midbrain development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of muscle cell apoptotic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in osteoblast fate commitment IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within osteoblast fate commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cartilage development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of cartilage development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of dendrite morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of pri-miRNA transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organonitrogen compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in ureteric bud development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ureteric bud development ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of heteromeric SMAD protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mothers against decapentaplegic homolog 1
Names
MAD (mothers against decapentaplegic, Drosophila) homolog 1
MAD homolog 1
MAD homolog1 (mothers against decapentaplegic, Drosophila)
SMAD 1
SMAD, mothers against DPP homolog 1
mothers against DPP homolog 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013130.3NP_037262.3  mothers against decapentaplegic homolog 1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000313
    Related
    ENSRNOP00000025079.4, ENSRNOT00000025079.6
    Conserved Domains (3) summary
    cd10490
    Location:9132
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:268468
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
    PRK10263
    Location:133244
    PRK10263; DNA translocase FtsK; Provisional

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051354.1 Reference mRatBN7.2 Primary Assembly

    Range
    28513130..28573665
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097521.1XP_038953449.1  mothers against decapentaplegic homolog 1 isoform X1

    Conserved Domains (3) summary
    cd10490
    Location:9132
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:283483
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
    PRK10263
    Location:133244
    PRK10263; DNA translocase FtsK; Provisional
  2. XM_006255394.2XP_006255456.1  mothers against decapentaplegic homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006255456.1

    Conserved Domains (3) summary
    cd10490
    Location:9132
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:283483
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
    PRK10263
    Location:133244
    PRK10263; DNA translocase FtsK; Provisional
  3. XM_006255397.2XP_006255459.1  mothers against decapentaplegic homolog 1 isoform X2

    Conserved Domains (3) summary
    cd10490
    Location:9132
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:276476
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
    pfam17093
    Location:185237
    PBP_N; Penicillin-binding protein N-terminus
  4. XM_039097522.1XP_038953450.1  mothers against decapentaplegic homolog 1 isoform X1

    Conserved Domains (3) summary
    cd10490
    Location:9132
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:283483
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
    PRK10263
    Location:133244
    PRK10263; DNA translocase FtsK; Provisional
  5. XM_006255395.4XP_006255457.1  mothers against decapentaplegic homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006255457.1

    Conserved Domains (3) summary
    cd10490
    Location:9132
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:283483
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
    PRK10263
    Location:133244
    PRK10263; DNA translocase FtsK; Provisional
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