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Scn5a sodium voltage-gated channel alpha subunit 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25665, updated on 10-Jul-2024

Summary

Official Symbol
Scn5aprovided by RGD
Official Full Name
sodium voltage-gated channel alpha subunit 5provided by RGD
Primary source
RGD:3637
See related
EnsemblRapid:ENSRNOG00000015049 AllianceGenome:RGD:3637
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SCAL; Scn2x; rSkM2; Nav1.5; RSKM2X; RATRSKM2X
Summary
Enables ankyrin binding activity; fibroblast growth factor binding activity; and voltage-gated sodium channel activity involved in cardiac muscle cell action potential. Involved in several processes, including animal organ development; response to denervation involved in regulation of muscle adaptation; and sodium ion import across plasma membrane. Located in T-tubule and intercalated disc. Biomarker of brain ischemia and congestive heart failure. Human ortholog(s) of this gene implicated in heart conduction disease (multiple); intrinsic cardiomyopathy (multiple); and sudden infant death syndrome. Orthologous to human SCN5A (sodium voltage-gated channel alpha subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 231.9) See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See Scn5a in Genome Data Viewer
Location:
8q32
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (128098613..128196515, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (119220905..119318816, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (128169191..128266681, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S27-like Neighboring gene exo/endonuclease G Neighboring gene uncharacterized LOC134480113 Neighboring gene sodium voltage-gated channel alpha subunit 10 Neighboring gene 40S ribosomal protein S27-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ankyrin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ankyrin binding IEA
Inferred from Electronic Annotation
more info
 
enables ankyrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ankyrin binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables fibroblast growth factor binding IEA
Inferred from Electronic Annotation
more info
 
enables fibroblast growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables fibroblast growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables nitric-oxide synthase binding IEA
Inferred from Electronic Annotation
more info
 
enables nitric-oxide synthase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated sodium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated sodium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated sodium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables voltage-gated sodium channel activity involved in AV node cell action potential IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated sodium channel activity involved in AV node cell action potential ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated sodium channel activity involved in AV node cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
enables voltage-gated sodium channel activity involved in Purkinje myocyte action potential IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated sodium channel activity involved in Purkinje myocyte action potential ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated sodium channel activity involved in Purkinje myocyte action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
enables voltage-gated sodium channel activity involved in SA node cell action potential IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated sodium channel activity involved in SA node cell action potential ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated sodium channel activity involved in SA node cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
enables voltage-gated sodium channel activity involved in bundle of His cell action potential IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated sodium channel activity involved in bundle of His cell action potential ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated sodium channel activity involved in bundle of His cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
enables voltage-gated sodium channel activity involved in cardiac muscle cell action potential IBA
Inferred from Biological aspect of Ancestor
more info
 
enables voltage-gated sodium channel activity involved in cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables voltage-gated sodium channel activity involved in cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated sodium channel activity involved in cardiac muscle cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in AV node cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in AV node cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in AV node cell to bundle of His cell communication ISO
Inferred from Sequence Orthology
more info
 
involved_in AV node cell to bundle of His cell communication ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in SA node cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in SA node cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in action potential IEA
Inferred from Electronic Annotation
more info
 
involved_in atrial cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in atrial cardiac muscle cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in brainstem development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in bundle of His cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in bundle of His cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cardiac muscle cell action potential involved in contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle cell action potential involved in contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within cardiac ventricle development ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cerebellum development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane depolarization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in membrane depolarization during AV node cell action potential IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane depolarization during AV node cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane depolarization during AV node cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in membrane depolarization during Purkinje myocyte cell action potential IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane depolarization during Purkinje myocyte cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane depolarization during Purkinje myocyte cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in membrane depolarization during SA node cell action potential IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane depolarization during SA node cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane depolarization during SA node cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in membrane depolarization during action potential IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in membrane depolarization during action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane depolarization during action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in membrane depolarization during atrial cardiac muscle cell action potential IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane depolarization during atrial cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane depolarization during bundle of His cell action potential IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane depolarization during bundle of His cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane depolarization during bundle of His cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in membrane depolarization during cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane depolarization during cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane depolarization during cardiac muscle cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuronal action potential IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in odontogenesis of dentin-containing tooth IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of atrial cardiac muscle cell membrane depolarization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of atrial cardiac muscle cell membrane depolarization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of atrial cardiac muscle cell membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of atrial cardiac muscle cell membrane depolarization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of atrial cardiac muscle cell membrane repolarization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of atrial cardiac muscle cell membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of atrial cardiac muscle cell membrane repolarization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cardiac muscle cell contraction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cardiac muscle cell contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle cell contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle cell contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of heart rate IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of heart rate ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of heart rate by cardiac conduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of heart rate by cardiac conduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of sodium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of ventricular cardiac muscle cell membrane depolarization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of ventricular cardiac muscle cell membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ventricular cardiac muscle cell membrane depolarization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of ventricular cardiac muscle cell membrane repolarization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of ventricular cardiac muscle cell membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ventricular cardiac muscle cell membrane repolarization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to denervation involved in regulation of muscle adaptation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in telencephalon development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in ventricular cardiac muscle cell action potential IEA
Inferred from Electronic Annotation
more info
 
involved_in ventricular cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in T-tubule IEA
Inferred from Electronic Annotation
more info
 
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
located_in Z disc ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in caveola IEA
Inferred from Electronic Annotation
more info
 
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in caveola ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intercalated disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in intercalated disc IEA
Inferred from Electronic Annotation
more info
 
located_in intercalated disc ISO
Inferred from Sequence Orthology
more info
 
located_in intercalated disc ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 
part_of sodium channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated sodium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated sodium channel complex IEA
Inferred from Electronic Annotation
more info
 
part_of voltage-gated sodium channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated sodium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
sodium channel protein type 5 subunit alpha
Names
skeletal muscle voltage-sensitive sodium channel subtype 2
sodium channel protein cardiac muscle subunit alpha
sodium channel protein type V subunit alpha
sodium channel, voltage-gated, type 5, alpha subunit
sodium channel, voltage-gated, type V, alpha polypeptide
sodium channel, voltage-gated, type V, alpha subunit
voltage-gated sodium channel Nav1.5c
voltage-gated sodium channel subunit alpha Nav1.5

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160162.3NP_001153634.2  sodium channel protein type 5 subunit alpha isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6I3X4, F1LNF5
    Conserved Domains (5) summary
    cd13433
    Location:14201472
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:11531428
    Ion_trans; Ion transport protein
    pfam06512
    Location:9561149
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:484668
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:17431790
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  2. NM_013125.4NP_037257.2  sodium channel protein type 5 subunit alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    P15389, Q925G6
    Conserved Domains (4) summary
    cd13433
    Location:14731525
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:12061481
    Ion_trans; Ion transport protein
    pfam06512
    Location:9561202
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510668
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    128098613..128196515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080899.2XP_038936827.1  sodium channel protein type 5 subunit alpha isoform X1

    UniProtKB/Swiss-Prot
    P15389, Q925G6
    UniProtKB/TrEMBL
    F1LPK3
    Related
    ENSRNOP00000060180.3, ENSRNOT00000064555.5
    Conserved Domains (5) summary
    cd13433
    Location:14741526
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:12071482
    Ion_trans; Ion transport protein
    pfam06512
    Location:9561203
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:484668
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:17971844
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  2. XM_039080901.2XP_038936829.1  sodium channel protein type 5 subunit alpha isoform X4

    UniProtKB/TrEMBL
    A6I3X4
    Related
    ENSRNOP00000060586.3, ENSRNOT00000066932.6
    Conserved Domains (5) summary
    cd13433
    Location:14201472
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:11531428
    Ion_trans; Ion transport protein
    pfam06512
    Location:9561149
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:484668
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:17431790
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  3. XM_017595481.3XP_017450970.1  sodium channel protein type 5 subunit alpha isoform X3

    UniProtKB/Swiss-Prot
    P15389, Q925G6
  4. XM_039080900.2XP_038936828.1  sodium channel protein type 5 subunit alpha isoform X2

    UniProtKB/Swiss-Prot
    P15389, Q925G6
    UniProtKB/TrEMBL
    A0A0G2JWG8
    Related
    ENSRNOP00000069875.2, ENSRNOT00000082892.3
    Conserved Domains (5) summary
    cd13433
    Location:14741526
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:12071482
    Ion_trans; Ion transport protein
    pfam06512
    Location:9561203
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:484668
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:17971844
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated