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Pparg peroxisome proliferator-activated receptor gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 25664, updated on 12-Jun-2018
Official Symbol
Ppargprovided by RGD
Official Full Name
peroxisome proliferator-activated receptor gammaprovided by RGD
Primary source
RGD:3371
See related
Ensembl:ENSRNOG00000008839
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
ligand-activated transcription factor; mediates expression of genes involved in lipid metabolism [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 110.5), Adrenal (RPKM 103.6) and 7 other tissues See more
Orthologs
See Pparg in Genome Data Viewer
Location:
4q42
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (147274055..147399383)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (210562928..210688585)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene synapsin II Neighboring gene hypothetical LOC100365210 Neighboring gene tubulin alpha-1C chain-like Neighboring gene TIMP metallopeptidase inhibitor 4 Neighboring gene uncharacterized LOC108350748 Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene MKRN2 opposite strand

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Huntington's disease, organism-specific biosystem (from KEGG)
    Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Huntington's disease, conserved biosystem (from KEGG)
    Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Longevity regulating pathway, organism-specific biosystem (from KEGG)
    Longevity regulating pathway, organism-specific biosystemRegulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that is limiting food intake, is recognized in mammals as the best characterized and most reproducible ...
  • Nuclear Receptor transcription pathway, organism-specific biosystem (from REACTOME)
    Nuclear Receptor transcription pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Nuclear Receptors, organism-specific biosystem (from WikiPathways)
    Nuclear Receptors, organism-specific biosystemNuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, th...
  • Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystem (from WikiPathways)
    Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystemNuclear receptors are transcription factors that are activated upon binding to its ligands. Initially, they had been classified as classic endocrine nuclear hormone receptors and orphan receptors. Ho...
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • PPAR signaling pathway, organism-specific biosystem (from KEGG)
    PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • PPAR signaling pathway, conserved biosystem (from KEGG)
    PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Thyroid cancer, organism-specific biosystem (from KEGG)
    Thyroid cancer, organism-specific biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
  • Thyroid cancer, conserved biosystem (from KEGG)
    Thyroid cancer, conserved biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
  • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
    Transcriptional misregulation in cancer, organism-specific biosystem
    Transcriptional misregulation in cancer
  • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
    Transcriptional misregulation in cancer, conserved biosystem
    Transcriptional misregulation in cancer
  • Transcriptional regulation of white adipocyte differentiation, organism-specific biosystem (from REACTOME)
    Transcriptional regulation of white adipocyte differentiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Wnt myofibroblastic activation of Hepatic Stellate Cells, organism-specific biosystem (from WikiPathways)
    Wnt myofibroblastic activation of Hepatic Stellate Cells, organism-specific biosystemThis pathway is modeled after figure 5 from Kweon et al. The WNT signaling pathway activates Beta-catenin which inhibits serine and cysteine proteases. This inhibition of these proteins increases Me...

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DBD domain binding IEA
Inferred from Electronic Annotation
more info
 
DBD domain binding ISO
Inferred from Sequence Orthology
more info
 
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
CONTRIBUTES_TO DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
LBD domain binding IEA
Inferred from Electronic Annotation
more info
 
LBD domain binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II repressing transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activating transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
activating transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
alpha-actinin binding IEA
Inferred from Electronic Annotation
more info
 
alpha-actinin binding ISO
Inferred from Sequence Orthology
more info
 
arachidonic acid binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
core promoter sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
drug binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
drug binding IEA
Inferred from Electronic Annotation
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
estrogen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 
nuclear receptor activity ISO
Inferred from Sequence Orthology
more info
 
nuclear receptor transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear receptor transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
nuclear receptor transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
peptide binding IEA
Inferred from Electronic Annotation
more info
 
peptide binding ISO
Inferred from Sequence Orthology
more info
 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein self-association IEA
Inferred from Electronic Annotation
more info
 
protein self-association ISO
Inferred from Sequence Orthology
more info
 
retinoid X receptor binding IEA
Inferred from Electronic Annotation
more info
 
retinoid X receptor binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
steroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor activity, RNA polymerase II transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor activity, direct ligand regulated sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
animal organ regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
cell maturation IEA
Inferred from Electronic Annotation
more info
 
cell maturation ISO
Inferred from Sequence Orthology
more info
 
cellular response to hyperoxia IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to lithium ion ISO
Inferred from Sequence Orthology
more info
 
cellular response to low-density lipoprotein particle stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to low-density lipoprotein particle stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
cellular response to prostaglandin E stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to prostaglandin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to vitamin E IEP
Inferred from Expression Pattern
more info
PubMed 
diet induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid metabolic process TAS
Traceable Author Statement
more info
PubMed 
fatty acid oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
heart development IEP
Inferred from Expression Pattern
more info
PubMed 
hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipoprotein transport IEA
Inferred from Electronic Annotation
more info
 
lipoprotein transport ISO
Inferred from Sequence Orthology
more info
 
long-chain fatty acid transport ISO
Inferred from Sequence Orthology
more info
 
low-density lipoprotein particle receptor biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
low-density lipoprotein particle receptor biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
macrophage derived foam cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
monocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
monocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of acute inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cholesterol storage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cholesterol storage IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cholesterol storage ISO
Inferred from Sequence Orthology
more info
 
negative regulation of collagen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of interferon-gamma-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interferon-gamma-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of macrophage derived foam cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of pancreatic stellate cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of peptide hormone secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of receptor biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of receptor biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of sequestering of triglyceride IEA
Inferred from Electronic Annotation
more info
 
negative regulation of sequestering of triglyceride ISO
Inferred from Sequence Orthology
more info
 
negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of telomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vascular endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vascular smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of vascular smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
peroxisome proliferator activated receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
peroxisome proliferator activated receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
placenta development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of fatty acid oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of vascular associated smooth muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vascular associated smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
pri-miRNA transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
regulation of lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IEP
Inferred from Expression Pattern
more info
PubMed 
regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription involved in cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription involved in cell fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
response to caffeine IEP
Inferred from Expression Pattern
more info
PubMed 
response to cold IEP
Inferred from Expression Pattern
more info
PubMed 
response to dietary excess ISO
Inferred from Sequence Orthology
more info
 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
response to food ISO
Inferred from Sequence Orthology
more info
 
response to immobilization stress IEP
Inferred from Expression Pattern
more info
PubMed 
response to light stimulus ISO
Inferred from Sequence Orthology
more info
 
response to lipid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to lipid IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipid ISO
Inferred from Sequence Orthology
more info
 
response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
response to metformin IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient levels IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
response to retinoic acid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
response to retinoic acid ISS
Inferred from Sequence or Structural Similarity
more info
 
response to starvation IEP
Inferred from Expression Pattern
more info
PubMed 
response to vitamin A IEP
Inferred from Expression Pattern
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
white fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
white fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
peroxisome proliferator-activated receptor gamma
Names
PPAR-gamma
nuclear receptor subfamily 1 group C member 3
peroxisome proliferator activator receptor, gamma

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145366.1NP_001138838.1  peroxisome proliferator-activated receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_001138838.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. Both variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC094445, AC136055
    UniProtKB/Swiss-Prot
    O88275
    Related
    ENSRNOP00000045012.3, ENSRNOT00000051858.5
    Conserved Domains (3) summary
    cd06932
    Location:207474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region
  2. NM_001145367.1NP_001138839.1  peroxisome proliferator-activated receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_001138839.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. Both variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC094445, AC136055
    UniProtKB/Swiss-Prot
    O88275
    Related
    ENSRNOP00000073235.1, ENSRNOT00000082969.1
    Conserved Domains (3) summary
    cd06932
    Location:207474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region
  3. NM_013124.3NP_037256.1  peroxisome proliferator-activated receptor gamma isoform 1

    See identical proteins and their annotated locations for NP_037256.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1)
    Source sequence(s)
    AC094445, AC136055
    UniProtKB/Swiss-Prot
    O88275
    Related
    ENSRNOP00000012137.3, ENSRNOT00000012137.5
    Conserved Domains (3) summary
    cd06932
    Location:237504
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:138221
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:31108
    PPARgamma_N; PPAR gamma N-terminal region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    147274055..147399383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237009.3XP_006237071.1  peroxisome proliferator-activated receptor gamma isoform X1

    See identical proteins and their annotated locations for XP_006237071.1

    UniProtKB/Swiss-Prot
    O88275
    Conserved Domains (3) summary
    cd06932
    Location:207474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    137316681..137440473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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