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Il1r1 interleukin 1 receptor type 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25663, updated on 13-Aug-2019

Summary

Official Symbol
Il1r1provided by RGD
Official Full Name
interleukin 1 receptor type 1provided by RGD
Primary source
RGD:2892
See related
Ensembl:ENSRNOG00000014504
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
receptor for interleukin-1; involved in inflammatory response signalling [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 238.9), Lung (RPKM 115.5) and 8 other tissues See more
Orthologs

Genomic context

See Il1r1 in Genome Data Viewer
Location:
9q22
Exon count:
16
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (46962291..47038139)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (46647422..46723241)

Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103690523 Neighboring gene similar to Zgc:56193 Neighboring gene interleukin 1 receptor-like 2 Neighboring gene interleukin 1 receptor-like 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Amoebiasis, organism-specific biosystem (from KEGG)
    Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Amoebiasis, conserved biosystem (from KEGG)
    Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hypertrophy Model, organism-specific biosystem (from WikiPathways)
    Hypertrophy Model, organism-specific biosystem
    Hypertrophy Model
  • IL-1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-1 Signaling Pathway, organism-specific biosystemThe interleukin 1 family of cytokines includes interleukin-1 alpha (IL1A), beta (IL1B) and the IL-1 receptor antagonist (IL1RN). These bind to the IL-1 receptor (IL1R1) as well as its decoy receptor,...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Interleukin-1 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-1 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
    NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • NF-kappa B signaling pathway, conserved biosystem (from KEGG)
    NF-kappa B signaling pathway, conserved biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multi-step process tha...
  • Th17 cell differentiation, organism-specific biosystem (from KEGG)
    Th17 cell differentiation, organism-specific biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
  • Th17 cell differentiation, conserved biosystem (from KEGG)
    Th17 cell differentiation, conserved biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
interleukin-1 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-1 binding IEA
Inferred from Electronic Annotation
more info
 
interleukin-1 binding ISO
Inferred from Sequence Orthology
more info
PubMed 
interleukin-1 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-1 receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
interleukin-1, type I, activating receptor activity IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
platelet-derived growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
platelet-derived growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protease binding IEA
Inferred from Electronic Annotation
more info
 
protease binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
heat acclimation IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
interleukin-1-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-1-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
interleukin-1-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
ovulation IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of T-helper 1 cell cytokine production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T-helper 1 cell cytokine production ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of T-helper 1 cell cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interferon-gamma production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interferon-gamma production ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of interferon-gamma production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-1-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neutrophil extravasation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neutrophil extravasation ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
PubMed 
response to epidermal growth factor IEP
Inferred from Expression Pattern
more info
PubMed 
response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
PubMed 
response to nitric oxide IEP
Inferred from Expression Pattern
more info
PubMed 
response to odorant IEP
Inferred from Expression Pattern
more info
PubMed 
response to radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to transforming growth factor beta IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
interleukin-1 receptor type 1
Names
CD121 antigen-like family member A
IL-1R-1
IL-1R-alpha
IL-1RT-1
IL-1RT1
interleukin 1 beta receptor type 1 short transmembrane form
interleukin 1 beta receptor type 1 soluble form
interleukin 1 bete receptor type 1 long transmembrane form
interleukin-1 receptor alpha
interleukin-1 receptor type I
p80

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013123.3NP_037255.3  interleukin-1 receptor type 1

    See identical proteins and their annotated locations for NP_037255.3

    Status: PROVISIONAL

    Source sequence(s)
    AB112437
    UniProtKB/TrEMBL
    Q05KR1
    Related
    ENSRNOP00000072248.1, ENSRNOT00000082408.1
    Conserved Domains (5) summary
    cd05757
    Location:144236
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00255
    Location:401556
    TIR; Toll - interleukin 1 - resistance
    smart00410
    Location:251344
    IG_like; Immunoglobulin like
    pfam13927
    Location:242333
    Ig_3; Immunoglobulin domain
    cl11960
    Location:47130
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005108.4 Reference Rnor_6.0 Primary Assembly

    Range
    46962291..47038139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244753.3XP_006244815.1  interleukin-1 receptor type 1 isoform X3

    See identical proteins and their annotated locations for XP_006244815.1

    UniProtKB/TrEMBL
    Q05KR0
    Conserved Domains (5) summary
    cd05757
    Location:127219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00255
    Location:384539
    TIR; Toll - interleukin 1 - resistance
    smart00410
    Location:234327
    IG_like; Immunoglobulin like
    pfam13927
    Location:225316
    Ig_3; Immunoglobulin domain
    cl11960
    Location:30113
    Ig; Immunoglobulin domain
  2. XM_006244747.3XP_006244809.1  interleukin-1 receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_006244809.1

    UniProtKB/TrEMBL
    Q05KR1
    Conserved Domains (5) summary
    cd05757
    Location:144236
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00255
    Location:401556
    TIR; Toll - interleukin 1 - resistance
    smart00410
    Location:251344
    IG_like; Immunoglobulin like
    pfam13927
    Location:242333
    Ig_3; Immunoglobulin domain
    cl11960
    Location:47130
    Ig; Immunoglobulin domain
  3. XM_006244752.3XP_006244814.1  interleukin-1 receptor type 1 isoform X3

    See identical proteins and their annotated locations for XP_006244814.1

    UniProtKB/TrEMBL
    Q05KR0
    Conserved Domains (5) summary
    cd05757
    Location:127219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00255
    Location:384539
    TIR; Toll - interleukin 1 - resistance
    smart00410
    Location:234327
    IG_like; Immunoglobulin like
    pfam13927
    Location:225316
    Ig_3; Immunoglobulin domain
    cl11960
    Location:30113
    Ig; Immunoglobulin domain
  4. XM_006244748.3XP_006244810.1  interleukin-1 receptor type 1 isoform X2

    See identical proteins and their annotated locations for XP_006244810.1

    UniProtKB/TrEMBL
    A0A0G2K6N4
    Related
    ENSRNOP00000073880.1, ENSRNOT00000082146.1
    Conserved Domains (5) summary
    cd05757
    Location:130222
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00255
    Location:387542
    TIR; Toll - interleukin 1 - resistance
    smart00410
    Location:237330
    IG_like; Immunoglobulin like
    pfam13927
    Location:228319
    Ig_3; Immunoglobulin domain
    cl11960
    Location:33116
    Ig; Immunoglobulin domain
  5. XM_006244750.3XP_006244812.1  interleukin-1 receptor type 1 isoform X3

    See identical proteins and their annotated locations for XP_006244812.1

    UniProtKB/TrEMBL
    Q05KR0
    Conserved Domains (5) summary
    cd05757
    Location:127219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00255
    Location:384539
    TIR; Toll - interleukin 1 - resistance
    smart00410
    Location:234327
    IG_like; Immunoglobulin like
    pfam13927
    Location:225316
    Ig_3; Immunoglobulin domain
    cl11960
    Location:30113
    Ig; Immunoglobulin domain
  6. XM_006244746.3XP_006244808.1  interleukin-1 receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_006244808.1

    UniProtKB/TrEMBL
    Q05KR1
    Related
    ENSRNOP00000019673.3, ENSRNOT00000019673.4
    Conserved Domains (5) summary
    cd05757
    Location:144236
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00255
    Location:401556
    TIR; Toll - interleukin 1 - resistance
    smart00410
    Location:251344
    IG_like; Immunoglobulin like
    pfam13927
    Location:242333
    Ig_3; Immunoglobulin domain
    cl11960
    Location:47130
    Ig; Immunoglobulin domain
  7. XM_006244754.3XP_006244816.1  interleukin-1 receptor type 1 isoform X3

    See identical proteins and their annotated locations for XP_006244816.1

    UniProtKB/TrEMBL
    Q05KR0
    Conserved Domains (5) summary
    cd05757
    Location:127219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00255
    Location:384539
    TIR; Toll - interleukin 1 - resistance
    smart00410
    Location:234327
    IG_like; Immunoglobulin like
    pfam13927
    Location:225316
    Ig_3; Immunoglobulin domain
    cl11960
    Location:30113
    Ig; Immunoglobulin domain
  8. XM_006244749.3XP_006244811.1  interleukin-1 receptor type 1 isoform X3

    See identical proteins and their annotated locations for XP_006244811.1

    UniProtKB/TrEMBL
    Q05KR0
    Conserved Domains (5) summary
    cd05757
    Location:127219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00255
    Location:384539
    TIR; Toll - interleukin 1 - resistance
    smart00410
    Location:234327
    IG_like; Immunoglobulin like
    pfam13927
    Location:225316
    Ig_3; Immunoglobulin domain
    cl11960
    Location:30113
    Ig; Immunoglobulin domain
  9. XM_008766993.2XP_008765215.1  interleukin-1 receptor type 1 isoform X3

    See identical proteins and their annotated locations for XP_008765215.1

    UniProtKB/TrEMBL
    Q05KR0
    Conserved Domains (5) summary
    cd05757
    Location:127219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00255
    Location:384539
    TIR; Toll - interleukin 1 - resistance
    smart00410
    Location:234327
    IG_like; Immunoglobulin like
    pfam13927
    Location:225316
    Ig_3; Immunoglobulin domain
    cl11960
    Location:30113
    Ig; Immunoglobulin domain
  10. XM_006244751.3XP_006244813.1  interleukin-1 receptor type 1 isoform X3

    See identical proteins and their annotated locations for XP_006244813.1

    UniProtKB/TrEMBL
    Q05KR0
    Related
    ENSRNOP00000075417.1, ENSRNOT00000087112.1
    Conserved Domains (5) summary
    cd05757
    Location:127219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00255
    Location:384539
    TIR; Toll - interleukin 1 - resistance
    smart00410
    Location:234327
    IG_like; Immunoglobulin like
    pfam13927
    Location:225316
    Ig_3; Immunoglobulin domain
    cl11960
    Location:30113
    Ig; Immunoglobulin domain

Alternate Rn_Celera

Genomic

  1. AC_000077.1 Alternate Rn_Celera

    Range
    40285956..40323730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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