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Igfbp2 insulin-like growth factor binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25662, updated on 22-May-2022

Summary

Official Symbol
Igfbp2provided by RGD
Official Full Name
insulin-like growth factor binding protein 2provided by RGD
Primary source
RGD:2873
See related
Ensembl:ENSRNOG00000016957 AllianceGenome:RGD:2873
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IBP-2; BRL-BP; IGFBP-2; ILGFBPA
Summary
Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in several processes, including response to estradiol; response to estrogen; and response to retinoic acid. Located in apical plasma membrane; cytoplasmic vesicle; and extracellular space. Biomarker of hypertension and hypothyroidism. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP2 (insulin like growth factor binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 1129.7), Liver (RPKM 507.1) and 4 other tissues See more
Orthologs
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Genomic context

See Igfbp2 in Genome Data Viewer
Location:
9q33
Exon count:
4
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (74415574..74442945)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (80118029..80144804)

Chromosome 9 - NC_051344.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094849 Neighboring gene uncharacterized LOC102547940 Neighboring gene insulin-like growth factor binding protein 5 Neighboring gene uncharacterized LOC120094704

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables insulin-like growth factor I binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables insulin-like growth factor I binding IDA
Inferred from Direct Assay
more info
PubMed 
enables insulin-like growth factor I binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables insulin-like growth factor I binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor II binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables insulin-like growth factor II binding IDA
Inferred from Direct Assay
more info
PubMed 
enables insulin-like growth factor II binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables insulin-like growth factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of activated T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of growth ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of growth IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of insulin-like growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of insulin-like growth factor receptor signaling pathway IC
Inferred by Curator
more info
PubMed 
involved_in regulation of insulin-like growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lithium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to steroid hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in signal transduction IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
insulin-like growth factor-binding protein 2
Names
IGF-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013122.2NP_037254.2  insulin-like growth factor-binding protein 2 precursor

    See identical proteins and their annotated locations for NP_037254.2

    Status: PROVISIONAL

    Source sequence(s)
    BC092570
    UniProtKB/Swiss-Prot
    P12843
    Related
    ENSRNOP00000023068.1, ENSRNOT00000023068.4
    Conserved Domains (2) summary
    smart00121
    Location:38116
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:206285
    Thyroglobulin_1; Thyroglobulin type-1 repeat

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051344.1 Reference mRatBN7.2 Primary Assembly

    Range
    74415574..74442945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)