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SERPINA11 serpin family A member 11 [ Homo sapiens (human) ]

Gene ID: 256394, updated on 24-Nov-2020

Summary

Official Symbol
SERPINA11provided by HGNC
Official Full Name
serpin family A member 11provided by HGNC
Primary source
HGNC:HGNC:19193
See related
Ensembl:ENSG00000186910
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Restricted expression toward liver (RPKM 125.9) See more
Orthologs

Genomic context

See SERPINA11 in Genome Data Viewer
Location:
14q32.13
Exon count:
5
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (94442438..94452857, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (94908801..94919122, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene serpin family A member 2 (gene/pseudogene) Neighboring gene serpin family A member 1 Neighboring gene uncharacterized LOC105370635 Neighboring gene serpin family A member 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genetically distinct subsets within ANCA-associated vasculitis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serpin A11
Names
antiproteinase-like 2
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080451.2NP_001073920.1  serpin A11 precursor

    See identical proteins and their annotated locations for NP_001073920.1

    Status: VALIDATED

    Source sequence(s)
    AL132708
    Consensus CDS
    CCDS32149.1
    UniProtKB/Swiss-Prot
    Q86U17
    Related
    ENSP00000335024.3, ENST00000334708.4
    Conserved Domains (1) summary
    cd02056
    Location:53416
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    94442438..94452857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720105.3XP_006720168.1  serpin A11 isoform X1

    Conserved Domains (1) summary
    cl00137
    Location:1212
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
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