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Fkbp1a FKBP prolyl isomerase 1A [ Rattus norvegicus (Norway rat) ]

Gene ID: 25639, updated on 30-Sep-2021

Summary

Official Symbol
Fkbp1aprovided by RGD
Official Full Name
FKBP prolyl isomerase 1Aprovided by RGD
Primary source
RGD:2617
See related
EnsemblRapid:ENSRNOG00000008822
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fkbp2; FKBP12
Summary
mediates islet microsome Ca2+ release through binding to ryanodine receptor (RyR) and catalyzes the cis-trans isomerization of peptidyl-prolyl amide peptide bonds [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 898.7), Lung (RPKM 748.5) and 9 other tissues See more
Orthologs
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Genomic context

See Fkbp1a in Genome Data Viewer
Location:
3q41
Exon count:
6
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (140040359..140060107)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (147042944..147062725)

Chromosome 3 - NC_051338.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548446 Neighboring gene similar to nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) Neighboring gene NSFL1 cofactor Neighboring gene uncharacterized LOC102548575 Neighboring gene syndecan binding protein 2 Neighboring gene syntaphilin Neighboring gene uncharacterized LOC120101750

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC156543

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables FK506 binding IDA
Inferred from Direct Assay
more info
PubMed 
enables FK506 binding ISO
Inferred from Sequence Orthology
more info
 
enables Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables activin binding ISO
Inferred from Sequence Orthology
more info
 
NOT enables calcium channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptidyl-prolyl cis-trans isomerase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transforming growth factor beta receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables type I transforming growth factor beta receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables type I transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in SMAD protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
 
involved_in chaperone-mediated protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in heart trabecula formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in negative regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in negative regulation of ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein peptidyl-prolyl isomerization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to caffeine ISO
Inferred from Sequence Orthology
more info
 
involved_in response to iron ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in supramolecular fiber organization ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic side of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extrinsic component of organelle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
part_of ryanodine receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in sarcoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in sarcoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP1A
Names
12 kDa FK506-binding protein
12 kDa FKBP
FK506 binding protein 1a
FK506 binding protein 2 (13 kDa)
FK506-binding protein 1 (12kD)
FK506-binding protein 1A
FKBP-12
FKBP-1A
PPIase FKBP1A
immunophilin FKBP12
rotamase
NP_037234.2
XP_038960313.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013102.3NP_037234.2  peptidyl-prolyl cis-trans isomerase FKBP1A

    See identical proteins and their annotated locations for NP_037234.2

    Status: PROVISIONAL

    Source sequence(s)
    BC070519
    UniProtKB/Swiss-Prot
    Q62658
    Related
    ENSRNOP00000012608.4, ENSRNOT00000012608.5
    Conserved Domains (1) summary
    COG0545
    Location:2106
    FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051338.1 Reference mRatBN7.2 Primary Assembly

    Range
    140040359..140060107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104385.1XP_038960313.1  peptidyl-prolyl cis-trans isomerase FKBP1A isoform X1

    Conserved Domains (1) summary
    pfam00254
    Location:176
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
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