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SCML4 Scm polycomb group protein like 4 [ Homo sapiens (human) ]

Gene ID: 256380, updated on 10-Oct-2019

Summary

Official Symbol
SCML4provided by HGNC
Official Full Name
Scm polycomb group protein like 4provided by HGNC
Primary source
HGNC:HGNC:21397
See related
Ensembl:ENSG00000146285
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dJ47M23.1
Expression
Biased expression in lymph node (RPKM 2.2), appendix (RPKM 1.5) and 13 other tissues See more
Orthologs

Genomic context

See SCML4 in Genome Data Viewer
Location:
6q21
Exon count:
17
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (107697297..107845959, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (108023361..108145521, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene decaprenyl diphosphate synthase subunit 2 Neighboring gene ribosomal protein S24 pseudogene 12 Neighboring gene sine oculis binding protein homolog Neighboring gene SEC63 homolog, protein translocation regulator Neighboring gene RNA, U6 small nuclear 437, pseudogene Neighboring gene ribosomal protein L23a pseudogene 50

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36252

Gene Ontology Provided by GOA

Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sex comb on midleg-like protein 4
Names
sex comb on midleg like 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286408.2NP_001273337.1  sex comb on midleg-like protein 4 isoform b

    See identical proteins and their annotated locations for NP_001273337.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon that results in the loss of a portion of the 5' UTR and 5' coding region, and it initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK093571, AL096816, BC021582, BC033286, BE349472
    Consensus CDS
    CCDS69163.1
    UniProtKB/Swiss-Prot
    Q8N228
    Related
    ENSP00000358018.2, ENST00000369022.6
    Conserved Domains (3) summary
    cd09578
    Location:282353
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:285353
    SAM; Sterile alpha motif
    pfam12140
    Location:37147
    DUF3588; Protein of unknown function (DUF3588)
  2. NM_001286409.2NP_001273338.1  sex comb on midleg-like protein 4 isoform c

    See identical proteins and their annotated locations for NP_001273338.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains alternate 5' exon structure and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AL096816, BC021582, BE349472
    Consensus CDS
    CCDS75500.1
    UniProtKB/TrEMBL
    A0A0B4J1S9
    Related
    ENSP00000358021.2, ENST00000369025.6
    Conserved Domains (1) summary
    cd09578
    Location:98169
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
  3. NM_198081.5NP_932347.2  sex comb on midleg-like protein 4 isoform a

    See identical proteins and their annotated locations for NP_932347.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK093571, AK303562, AL096816, BC021582, BC033286, BE349472
    Consensus CDS
    CCDS5060.2
    UniProtKB/Swiss-Prot
    Q8N228
    UniProtKB/TrEMBL
    B4E0X3
    Related
    ENSP00000358016.3, ENST00000369020.8
    Conserved Domains (3) summary
    cd09578
    Location:340411
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:343411
    SAM; Sterile alpha motif
    pfam12140
    Location:95205
    DUF3588; Protein of unknown function (DUF3588)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    107697297..107845959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010680.1XP_016866169.1  sex comb on midleg-like protein 4 isoform X2

    UniProtKB/Swiss-Prot
    Q8N228
    Conserved Domains (3) summary
    cd09578
    Location:340411
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:343411
    SAM; Sterile alpha motif
    pfam12140
    Location:95205
    DUF3588; Protein of unknown function (DUF3588)
  2. XM_017010687.1XP_016866176.1  sex comb on midleg-like protein 4 isoform X9

  3. XM_017010685.1XP_016866174.1  sex comb on midleg-like protein 4 isoform X7

  4. XM_017010677.1XP_016866166.1  sex comb on midleg-like protein 4 isoform X1

  5. XM_017010686.1XP_016866175.1  sex comb on midleg-like protein 4 isoform X8

  6. XM_017010678.1XP_016866167.1  sex comb on midleg-like protein 4 isoform X2

    UniProtKB/Swiss-Prot
    Q8N228
    Conserved Domains (3) summary
    cd09578
    Location:340411
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:343411
    SAM; Sterile alpha motif
    pfam12140
    Location:95205
    DUF3588; Protein of unknown function (DUF3588)
  7. XM_011535703.2XP_011534005.1  sex comb on midleg-like protein 4 isoform X5

    See identical proteins and their annotated locations for XP_011534005.1

    Conserved Domains (3) summary
    cd09578
    Location:311382
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:314382
    SAM; Sterile alpha motif
    pfam12140
    Location:66176
    DUF3588; Protein of unknown function (DUF3588)
  8. XM_011535706.1XP_011534008.1  sex comb on midleg-like protein 4 isoform X4

    See identical proteins and their annotated locations for XP_011534008.1

    UniProtKB/Swiss-Prot
    Q8N228
    Conserved Domains (3) summary
    cd09578
    Location:282353
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:285353
    SAM; Sterile alpha motif
    pfam12140
    Location:37147
    DUF3588; Protein of unknown function (DUF3588)
  9. XM_017010683.1XP_016866172.1  sex comb on midleg-like protein 4 isoform X4

    UniProtKB/Swiss-Prot
    Q8N228
    Conserved Domains (3) summary
    cd09578
    Location:282353
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:285353
    SAM; Sterile alpha motif
    pfam12140
    Location:37147
    DUF3588; Protein of unknown function (DUF3588)
  10. XM_017010679.1XP_016866168.1  sex comb on midleg-like protein 4 isoform X2

    UniProtKB/Swiss-Prot
    Q8N228
    Conserved Domains (3) summary
    cd09578
    Location:340411
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:343411
    SAM; Sterile alpha motif
    pfam12140
    Location:95205
    DUF3588; Protein of unknown function (DUF3588)
  11. XM_017010681.1XP_016866170.1  sex comb on midleg-like protein 4 isoform X2

    UniProtKB/Swiss-Prot
    Q8N228
    Conserved Domains (3) summary
    cd09578
    Location:340411
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:343411
    SAM; Sterile alpha motif
    pfam12140
    Location:95205
    DUF3588; Protein of unknown function (DUF3588)
  12. XM_011535704.2XP_011534006.1  sex comb on midleg-like protein 4 isoform X5

    See identical proteins and their annotated locations for XP_011534006.1

    Conserved Domains (3) summary
    cd09578
    Location:311382
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:314382
    SAM; Sterile alpha motif
    pfam12140
    Location:66176
    DUF3588; Protein of unknown function (DUF3588)
  13. XM_011535710.2XP_011534012.1  sex comb on midleg-like protein 4 isoform X12

    See identical proteins and their annotated locations for XP_011534012.1

    UniProtKB/TrEMBL
    A0A0B4J1S9
    Conserved Domains (1) summary
    cd09578
    Location:98169
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
  14. XM_011535709.2XP_011534011.1  sex comb on midleg-like protein 4 isoform X12

    See identical proteins and their annotated locations for XP_011534011.1

    UniProtKB/TrEMBL
    A0A0B4J1S9
    Conserved Domains (1) summary
    cd09578
    Location:98169
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
  15. XM_017010682.2XP_016866171.1  sex comb on midleg-like protein 4 isoform X3

  16. XM_017010684.1XP_016866173.1  sex comb on midleg-like protein 4 isoform X6

  17. XM_011535707.2XP_011534009.1  sex comb on midleg-like protein 4 isoform X10

    Conserved Domains (1) summary
    pfam12140
    Location:95205
    DUF3588; Protein of unknown function (DUF3588)
  18. XM_017010688.1XP_016866177.1  sex comb on midleg-like protein 4 isoform X11

RNA

  1. XR_001743305.1 RNA Sequence

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