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GK5 glycerol kinase 5 [ Homo sapiens (human) ]

Gene ID: 256356, updated on 23-Nov-2021

Summary

Official Symbol
GK5provided by HGNC
Official Full Name
glycerol kinase 5provided by HGNC
Primary source
HGNC:HGNC:28635
See related
Ensembl:ENSG00000175066
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in prostate (RPKM 6.0), duodenum (RPKM 4.3) and 25 other tissues See more
Orthologs
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Genomic context

See GK5 in Genome Data Viewer
Location:
3q23
Exon count:
19
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (142157527..142225592, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (141876369..141944427, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transcription factor Dp-2 Neighboring gene ribosomal protein L19 pseudogene 6 Neighboring gene RNA, U6 small nuclear 425, pseudogene Neighboring gene Sharpr-MPRA regulatory region 12219 Neighboring gene 5'-3' exoribonuclease 1 Neighboring gene RNA, U6 small nuclear 1294, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33582, FLJ45739, MGC40579

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables glycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphotransferase activity, alcohol group as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in glycerol catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glycerol-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in triglyceride metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
putative glycerol kinase 5
Names
ATP:glycerol 3-phosphotransferase 5
GK 5
glycerokinase 5
glycerol kinase 5 (putative)
NP_001034636.1
XP_011510926.1
XP_016861577.1
XP_016861578.1
XP_016861579.1
XP_024309204.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039547.3NP_001034636.1  putative glycerol kinase 5

    See identical proteins and their annotated locations for NP_001034636.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.
    Source sequence(s)
    AC108679, AK127641, BU628781, BX648359, DR000158
    Consensus CDS
    CCDS33871.1
    UniProtKB/Swiss-Prot
    Q6ZS86
    Related
    ENSP00000418001.1, ENST00000392993.7
    Conserved Domains (2) summary
    cd07793
    Location:20522
    FGGY_GK5_metazoa; metazoan glycerol kinase 5-like proteins; belongs to the FGGY family of carbohydrate kinases
    COG0554
    Location:19525
    GlpK; Glycerol kinase [Energy production and conversion]

RNA

  1. NR_033289.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an additional exon in the central region, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC108679, BU628781, BX648681, DR000158

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    142157527..142225592 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006090.2XP_016861579.1  putative glycerol kinase 5 isoform X4

    Conserved Domains (2) summary
    COG0554
    Location:18291
    GlpK; Glycerol kinase [Energy production and conversion]
    cl17037
    Location:18288
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. XM_011512624.3XP_011510926.1  putative glycerol kinase 5 isoform X2

    Conserved Domains (1) summary
    cd07793
    Location:1437
    FGGY_GK5_metazoa; metazoan glycerol kinase 5-like proteins; belongs to the FGGY family of carbohydrate kinases
  3. XM_024453436.1XP_024309204.1  putative glycerol kinase 5 isoform X3

    Conserved Domains (1) summary
    cl17037
    Location:2386
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  4. XM_017006089.2XP_016861578.1  putative glycerol kinase 5 isoform X3

    Conserved Domains (1) summary
    cl17037
    Location:2386
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  5. XM_017006088.1XP_016861577.1  putative glycerol kinase 5 isoform X1

    Conserved Domains (1) summary
    cd07793
    Location:20480
    FGGY_GK5_metazoa; metazoan glycerol kinase 5-like proteins; belongs to the FGGY family of carbohydrate kinases

RNA

  1. XR_002959504.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152776.1: Suppressed sequence

    Description
    NM_152776.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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