GK5 glycerol kinase 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GK5provided by HGNC
Official Full Name: glycerol kinase 5provided by HGNC
Primary source: HGNC:HGNC:28635
See related: Ensembl:ENSG00000175066 AllianceGenome:HGNC:28635
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to enable glycerol kinase activity. Predicted to be involved in several processes, including glycerol metabolic process; glycerol-3-phosphate biosynthetic process; and triglyceride metabolic process. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in prostate (RPKM 6.0), duodenum (RPKM 4.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q23

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (142157527..142225585, complement)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (144904825..144972879, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (141876369..141944427, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-135b may function as an oncogene by inhibiting GK5 in glioblastoma.
Title: MicroRNA-135b exerts oncogenic activity in glioblastoma via the inhibition of glycerol kinase 5 expression.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

NoName (e-PCR)
- UniSTS:9484

GDB:434012 (e-PCR)
- UniSTS:157204

D11S2560 (e-PCR)
- UniSTS:37928

D8S2279 (e-PCR)
- UniSTS:473907

D8S2282 (e-PCR)
- UniSTS:473910

D10S2448 (e-PCR)
- UniSTS:474444

D22S1584 (e-PCR)
- UniSTS:473695

D1S1425 (e-PCR)
- UniSTS:149621

G35510 (e-PCR)
- UniSTS:44150

D3S4133 (e-PCR)
- UniSTS:74142

STS-N22251 (e-PCR)
- UniSTS:18894

GDB:631802 (e-PCR)
- UniSTS:158429

Homology

Homologs of the GK5 gene: The GK5 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline: 501 organisms have orthologs with human gene GK5
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables glycerol kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycerol catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerol metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in glycerol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in phosphorylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in triglyceride metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: putative glycerol kinase 5

Names: ATP:glycerol 3-phosphotransferase 5; GK 5; glycerokinase 5; glycerol kinase 5 (putative)

NP_001034636.1

EC 2.7.1.30

XP_024309204.1

EC 2.7.1.30

XP_047303853.1

EC 2.7.1.30

XP_047303854.1

EC 2.7.1.30

XP_054201982.1

EC 2.7.1.30

XP_054201983.1

EC 2.7.1.30

XP_054201984.1

EC 2.7.1.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039547.3 → NP_001034636.1 putative glycerol kinase 5

See identical proteins and their annotated locations for NP_001034636.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.

Source sequence(s)

AC108679, AK127641, BU628781, BX648359, DR000158

Consensus CDS

CCDS33871.1

UniProtKB/Swiss-Prot

Q6ZS86, Q8N5E6

Related

ENSP00000418001.1, ENST00000392993.7

Conserved Domains (2) summary

cd07793
Location:20 → 522

FGGY_GK5_metazoa; metazoan glycerol kinase 5-like proteins; belongs to the FGGY family of carbohydrate kinases

COG0554
Location:19 → 525

GlpK; Glycerol kinase [Energy production and conversion]

RNA

NR_033289.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) includes an additional exon in the central region, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC108679, BU628781, BX648681, DR000158

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

142157527..142225585 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024453436.2 → XP_024309204.1 putative glycerol kinase 5 isoform X1

Conserved Domains (1) summary

cl17037
Location:2 → 386

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
XM_047447898.1 → XP_047303854.1 putative glycerol kinase 5 isoform X3
XM_047447897.1 → XP_047303853.1 putative glycerol kinase 5 isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

144904825..144972879 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054346007.1 → XP_054201982.1 putative glycerol kinase 5 isoform X1
XM_054346009.1 → XP_054201984.1 putative glycerol kinase 5 isoform X3
XM_054346008.1 → XP_054201983.1 putative glycerol kinase 5 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_152776.1: Suppressed sequence

Description

NM_152776.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.