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GK5 glycerol kinase 5 [ Homo sapiens (human) ]

Gene ID: 256356, updated on 5-Jul-2025
Official Symbol
GK5provided by HGNC
Official Full Name
glycerol kinase 5provided by HGNC
Primary source
HGNC:HGNC:28635
See related
Ensembl:ENSG00000175066 MIM:620801; AllianceGenome:HGNC:28635
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable glycerol kinase activity. Predicted to be involved in glycerol metabolic process; glycerol-3-phosphate biosynthetic process; and triglyceride metabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in prostate (RPKM 6.0), duodenum (RPKM 4.3) and 25 other tissues See more
Orthologs
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See GK5 in Genome Data Viewer
Location:
3q23
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (142157527..142225585, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (144904825..144972879, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (141876369..141944427, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transcription factor Dp-2 Neighboring gene ribosomal protein L19 pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14784 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:141868031-141868531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14787 Neighboring gene NANOG hESC enhancer GRCh37_chr3:141883131-141883866 Neighboring gene RNA, U6 small nuclear 425, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14788 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14789 Neighboring gene NANOG hESC enhancer GRCh37_chr3:141961954-141962455 Neighboring gene Sharpr-MPRA regulatory region 12219 Neighboring gene 5'-3' exoribonuclease 1 Neighboring gene RNA, U6 small nuclear 1294, pseudogene Neighboring gene RNA, U1 small nuclear 100, pseudogene

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. MicroRNA-135b exerts oncogenic activity in glioblastoma via the inhibition of glycerol kinase 5 expression. Yu Y, et al. Mol Med Rep, 2015 Aug. PMID 25936394
  2. Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5. Zhang D, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28607088, Free PMC Article
  3. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
  4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  5. Physical and functional interactome atlas of human receptor tyrosine kinases. Salokas K, et al. EMBO Rep, 2022 Jun 7. PMID 35384245, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-135b may function as an oncogene by inhibiting GK5 in glioblastoma.
    Title: MicroRNA-135b exerts oncogenic activity in glioblastoma via the inhibition of glycerol kinase 5 expression.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ33582, FLJ45739, MGC40579

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables glycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerol kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol-3-phosphate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in triglyceride metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HTP PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
glycerol kinase 5; putative glycerol kinase 5
Names
ATP:glycerol 3-phosphotransferase 5
GK 5
glycerokinase 5
glycerol kinase 5 (putative)
NP_001034636.1
XP_024309204.1
XP_047303853.1
XP_047303854.1
XP_054201982.1
XP_054201983.1
XP_054201984.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039547.3 → NP_001034636.1  glycerol kinase 5

    See identical proteins and their annotated locations for NP_001034636.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.
    Source sequence(s)
    AC108679, AK127641, BU628781, BX648359, DR000158
    Consensus CDS
    CCDS33871.1
    UniProtKB/Swiss-Prot
    B2R9I2, D3DNG2, Q6ZS86, Q8N2A7, Q8N5E6
    Related
    ENSP00000418001.1, ENST00000392993.7
    Conserved Domains (2) summary
    cd07793
    Location:20 → 522
    FGGY_GK5_metazoa; metazoan glycerol kinase 5-like proteins; belongs to the FGGY family of carbohydrate kinases
    COG0554
    Location:19 → 525
    GlpK; Glycerol kinase [Energy production and conversion]

RNA

  1. NR_033289.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an additional exon in the central region, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC108679, BU628781, BX648681, DR000158

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    142157527..142225585 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453436.2 → XP_024309204.1  putative glycerol kinase 5 isoform X1

    Conserved Domains (1) summary
    cl17037
    Location:2 → 386
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. XM_047447898.1 → XP_047303854.1  putative glycerol kinase 5 isoform X3

  3. XM_047447897.1 → XP_047303853.1  putative glycerol kinase 5 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    144904825..144972879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346007.1 → XP_054201982.1  putative glycerol kinase 5 isoform X1

  2. XM_054346009.1 → XP_054201984.1  putative glycerol kinase 5 isoform X3

  3. XM_054346008.1 → XP_054201983.1  putative glycerol kinase 5 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152776.1: Suppressed sequence

    Description
    NM_152776.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZS86.2 GenPept UniProtKB/Swiss-Prot:Q6ZS86

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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