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NUDT14 nudix hydrolase 14 [ Homo sapiens (human) ]

Gene ID: 256281, updated on 23-Nov-2021

Summary

Official Symbol
NUDT14provided by HGNC
Official Full Name
nudix hydrolase 14provided by HGNC
Primary source
HGNC:HGNC:20141
See related
Ensembl:ENSG00000183828 MIM:609219
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UGPP; UGPPase
Summary
The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This enzyme contains a Nudix hydrolase domain and is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in fat (RPKM 8.0), kidney (RPKM 7.1) and 25 other tissues See more
Orthologs
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Genomic context

See NUDT14 in Genome Data Viewer
Location:
14q32.33
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (105172939..105181312, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (105639276..105647649, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2298 Neighboring gene microRNA 6765 Neighboring gene jagged canonical Notch ligand 2 Neighboring gene BRF1 RNA polymerase III transcription initiation factor subunit Neighboring gene BTB domain containing 6 Neighboring gene phosphofurin acidic cluster sorting protein 2 Neighboring gene ribosomal protein S20 pseudogene 33

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ17491

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ADP-ribose diphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables UDP-sugar diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables UDP-sugar diphosphatase activity TAS
Traceable Author Statement
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in nucleoside phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein N-linked glycosylation via asparagine TAS
Traceable Author Statement
more info
 
involved_in ribose phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
uridine diphosphate glucose pyrophosphatase NUDT14
Names
UDP-sugar diphosphatase
UDPG pyrophosphatase
nudix (nucleoside diphosphate linked moiety X)-type motif 14
NP_001305309.1
NP_803877.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318380.2NP_001305309.1  uridine diphosphate glucose pyrophosphatase NUDT14 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region. It encodes isoform 2 which has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL512355
    UniProtKB/TrEMBL
    B3KXY7
    Related
    ENST00000551024.5
    Conserved Domains (1) summary
    TIGR00052
    Location:23149
    TIGR00052; nudix-type nucleoside diphosphatase, YffH/AdpP family
  2. NM_177533.5NP_803877.2  uridine diphosphate glucose pyrophosphatase NUDT14 isoform 1

    See identical proteins and their annotated locations for NP_803877.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC041584, DB096906
    Consensus CDS
    CCDS10000.1
    UniProtKB/Swiss-Prot
    O95848
    Related
    ENSP00000376349.2, ENST00000392568.7
    Conserved Domains (1) summary
    TIGR00052
    Location:23212
    TIGR00052; nudix-type nucleoside diphosphatase, YffH/AdpP family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    105172939..105181312 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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