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Hspa5 heat shock protein family A (Hsp70) member 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25617, updated on 9-Mar-2023

Summary

Official Symbol
Hspa5provided by RGD
Official Full Name
heat shock protein family A (Hsp70) member 5provided by RGD
Primary source
RGD:2843
See related
Ensembl:ENSRNOG00000018294 AllianceGenome:RGD:2843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
BIP; GRP78; GRP 78
Summary
Enables misfolded protein binding activity and unfolded protein binding activity. Involved in several processes, including cellular response to cAMP; cellular response to gamma radiation; and cellular response to metal ion. Acts upstream of or within response to endoplasmic reticulum stress. Located in membrane; mitochondrion; and smooth endoplasmic reticulum. Biomarker of fatty liver disease; post-traumatic stress disorder; transient cerebral ischemia; ureteral obstruction; and visual epilepsy. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (Hsp70) member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 2693.8), Heart (RPKM 2015.3) and 9 other tissues See more
Orthologs
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Genomic context

See Hspa5 in Genome Data Viewer
Location:
3p11
Exon count:
9
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (18055507..18059969)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (13838304..13842763)

Chromosome 3 - NC_051338.1Genomic Context describing neighboring genes Neighboring gene MAPK associated protein 1 Neighboring gene ribosomal protein S7, pseudogene 1 Neighboring gene GTPase activating protein and VPS9 domains 1 Neighboring gene uncharacterized LOC120101527 Neighboring gene Rab9 effector protein with kelch motifs Neighboring gene F-box and WD repeat domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables misfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables misfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
 
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within ER overload response ISO
Inferred from Sequence Orthology
more info
 
involved_in IRE1-mediated unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to antibiotic IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to cAMP IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to calcium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to gamma radiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to interleukin-4 ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to manganese ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to nerve growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cerebellar Purkinje cell layer development ISO
Inferred from Sequence Orthology
more info
 
involved_in cerebellum structural organization ISO
Inferred from Sequence Orthology
more info
 
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
involved_in luteolysis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in maintenance of protein localization in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
involved_in maintenance of protein localization in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of IRE1-mediated unfolded protein response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein-containing complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron apoptotic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in neuron differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in post-translational protein targeting to membrane, translocation ISO
Inferred from Sequence Orthology
more info
 
involved_in post-translational protein targeting to membrane, translocation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteolysis involved in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cocaine IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to endoplasmic reticulum stress IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to methamphetamine hydrochloride IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to radiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in stress response to metal ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in substantia nigra development ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within toxin transport ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of COP9 signalosome IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
part_of endoplasmic reticulum chaperone complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of endoplasmic reticulum chaperone complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum lumen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in smooth endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
endoplasmic reticulum chaperone BiP
Names
78 kDa glucose-regulated protein
GRP-78
HSP70 family protein 5
binding-immunoglobulin protein
heat shock 70 kDa protein 5
heat shock 70kD protein 5
heat shock 70kDa protein 5 (glucose-regulated protein)
heat shock protein 5
heat shock protein 70 family protein 5
heat shock protein family A member 5
immunoglobulin heavy chain-binding protein
steroidogenesis-activator polypeptide
NP_037215.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013083.2NP_037215.1  endoplasmic reticulum chaperone BiP precursor

    See identical proteins and their annotated locations for NP_037215.1

    Status: VALIDATED

    Source sequence(s)
    BC062017, CB327067, CB578015, M14050
    UniProtKB/Swiss-Prot
    P06761
    Related
    ENSRNOP00000025064.5, ENSRNOT00000025067.7
    Conserved Domains (2) summary
    cd10241
    Location:28403
    HSPA5-like_NBD; Nucleotide-binding domain of human HSPA5 and similar proteins
    pfam00012
    Location:30635
    HSP70; Hsp70 protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051338.1 Reference mRatBN7.2 Primary Assembly

    Range
    18055507..18059969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)