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HMCN2 hemicentin 2 [ Homo sapiens (human) ]

Gene ID: 256158, updated on 4-Jul-2021

Summary

Official Symbol
HMCN2provided by HGNC
Official Full Name
hemicentin 2provided by HGNC
Primary source
HGNC:HGNC:21293
See related
Ensembl:ENSG00000148357
Gene type
protein coding
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in small intestine (RPKM 2.1), fat (RPKM 1.8) and 19 other tissues See more
Orthologs
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Genomic context

See HMCN2 in Genome Data Viewer
Location:
9q34.11
Exon count:
102
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (130265742..130434123)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (133028039..133309510)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4503 Neighboring gene microRNA 12126 Neighboring gene RNA, 7SL, cytoplasmic 665, pseudogene Neighboring gene uncharacterized LOC107987134 Neighboring gene argininosuccinate synthase 1 Neighboring gene VISTA enhancer hs1328 Neighboring gene uncharacterized LOC105376294 Neighboring gene Sharpr-MPRA regulatory region 5386

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of hemicentin 2 (HMCN2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed
Knockdown of hemicentin 2 (HMCN2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23816, FLJ46139, FLJ46844, DKFZp434P0216

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Process Evidence Code Pubs
involved_in response to stimulus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cleavage furrow IEA
Inferred from Electronic Annotation
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291815.2NP_001278744.1  hemicentin-2 precursor

    Status: INFERRED

    Source sequence(s)
    ABBA01012042, ABBA01043973, AL354898, AL360004, FP565345, KF458942
    Related
    ENSP00000508292.1, ENST00000683500.1
    Conserved Domains (11) summary
    cd00096
    Location:19121975
    Ig; Immunoglobulin domain
    smart00408
    Location:42474309
    IGc2; Immunoglobulin C-2 Type
    smart00179
    Location:48834922
    EGF_CA; Calcium-binding EGF-like domain
    smart00409
    Location:792879
    IG; Immunoglobulin
    smart00410
    Location:29543034
    IG_like; Immunoglobulin like
    pfam07679
    Location:43234409
    I-set; Immunoglobulin I-set domain
    pfam07474
    Location:44114593
    G2F; G2F domain
    pfam07645
    Location:47334774
    EGF_CA; Calcium-binding EGF domain
    pfam13519
    Location:39209
    VWA_2; von Willebrand factor type A domain
    pfam14670
    Location:46524687
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl11960
    Location:43224405
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    130265742..130434123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518466.2XP_011516768.1  hemicentin-2 isoform X2

    Conserved Domains (11) summary
    cd00096
    Location:19121975
    Ig; Immunoglobulin domain
    smart00408
    Location:42474309
    IGc2; Immunoglobulin C-2 Type
    smart00179
    Location:48394878
    EGF_CA; Calcium-binding EGF-like domain
    smart00409
    Location:792879
    IG; Immunoglobulin
    smart00410
    Location:29543034
    IG_like; Immunoglobulin like
    pfam07679
    Location:43234409
    I-set; Immunoglobulin I-set domain
    pfam07474
    Location:44114593
    G2F; G2F domain
    pfam07645
    Location:46894730
    EGF_CA; Calcium-binding EGF domain
    pfam13519
    Location:39209
    VWA_2; von Willebrand factor type A domain
    pfam14670
    Location:46524687
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl11960
    Location:43224405
    Ig; Immunoglobulin domain
  2. XM_011518465.2XP_011516767.1  hemicentin-2 isoform X1

    Conserved Domains (10) summary
    cd00096
    Location:19121975
    Ig; Immunoglobulin domain
    smart00408
    Location:42474309
    IGc2; Immunoglobulin C-2 Type
    smart00179
    Location:48424881
    EGF_CA; Calcium-binding EGF-like domain
    smart00409
    Location:792879
    IG; Immunoglobulin
    smart00410
    Location:29543034
    IG_like; Immunoglobulin like
    pfam07679
    Location:43234409
    I-set; Immunoglobulin I-set domain
    pfam07474
    Location:44114593
    G2F; G2F domain
    pfam07645
    Location:46924733
    EGF_CA; Calcium-binding EGF domain
    pfam13519
    Location:39209
    VWA_2; von Willebrand factor type A domain
    cl11960
    Location:43224405
    Ig; Immunoglobulin domain
  3. XM_011518467.2XP_011516769.1  hemicentin-2 isoform X3

    Conserved Domains (11) summary
    cd00096
    Location:715779
    Ig; Immunoglobulin domain
    smart00408
    Location:41884250
    IGc2; Immunoglobulin C-2 Type
    smart00179
    Location:48244863
    EGF_CA; Calcium-binding EGF-like domain
    smart00409
    Location:792879
    IG; Immunoglobulin
    smart00410
    Location:12581340
    IG_like; Immunoglobulin like
    pfam07679
    Location:42644350
    I-set; Immunoglobulin I-set domain
    pfam07474
    Location:43524534
    G2F; G2F domain
    pfam07645
    Location:46744715
    EGF_CA; Calcium-binding EGF domain
    pfam13519
    Location:39209
    VWA_2; von Willebrand factor type A domain
    pfam14670
    Location:45934628
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl11960
    Location:42634346
    Ig; Immunoglobulin domain
  4. XM_011518468.2XP_011516770.1  hemicentin-2 isoform X4

    Conserved Domains (11) summary
    cd00096
    Location:19121975
    Ig; Immunoglobulin domain
    smart00408
    Location:42474309
    IGc2; Immunoglobulin C-2 Type
    smart00179
    Location:46894732
    EGF_CA; Calcium-binding EGF-like domain
    smart00409
    Location:792879
    IG; Immunoglobulin
    smart00410
    Location:33293410
    IG_like; Immunoglobulin like
    pfam07679
    Location:43234409
    I-set; Immunoglobulin I-set domain
    pfam07474
    Location:44114593
    G2F; G2F domain
    pfam07645
    Location:47334774
    EGF_CA; Calcium-binding EGF domain
    pfam13519
    Location:39209
    VWA_2; von Willebrand factor type A domain
    pfam14670
    Location:46524687
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl11960
    Location:43224405
    Ig; Immunoglobulin domain
  5. XM_011518469.2XP_011516771.1  hemicentin-2 isoform X6

    Conserved Domains (7) summary
    cd00096
    Location:19121975
    Ig; Immunoglobulin domain
    smart00408
    Location:13601423
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:792879
    IG; Immunoglobulin
    smart00410
    Location:12581340
    IG_like; Immunoglobulin like
    pfam07679
    Location:30383129
    I-set; Immunoglobulin I-set domain
    pfam13519
    Location:39209
    VWA_2; von Willebrand factor type A domain
    cl11960
    Location:28682942
    Ig; Immunoglobulin domain
  6. XM_011518470.2XP_011516772.1  hemicentin-2 isoform X7

    Conserved Domains (7) summary
    cd00096
    Location:19121975
    Ig; Immunoglobulin domain
    smart00408
    Location:13601423
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:792879
    IG; Immunoglobulin
    smart00410
    Location:25582638
    IG_like; Immunoglobulin like
    pfam07679
    Location:608692
    I-set; Immunoglobulin I-set domain
    pfam13519
    Location:39209
    VWA_2; von Willebrand factor type A domain
    cl11960
    Location:28682942
    Ig; Immunoglobulin domain
  7. XM_017014585.1XP_016870074.1  hemicentin-2 isoform X5

  8. XM_017014586.1XP_016870075.1  hemicentin-2 isoform X8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_144655.1: Suppressed sequence

    Description
    NM_144655.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
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