Ptprz1 protein tyrosine phosphatase, receptor type Z1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptprz1provided by RGD
Official Full Name: protein tyrosine phosphatase, receptor type Z1provided by RGD
Primary source: RGD:3455
See related: Ensembl:ENSRNOG00000006030 AllianceGenome:RGD:3455
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ptpz; RPTPbeta; PTPzeta-A; PTPzeta-B; PTPzeta-S
Summary: Enables fibroblast growth factor binding activity and protein tyrosine phosphatase activity. Involved in several processes, including nervous system development; positive regulation of cell migration; and regulation of dendrite development. Located in several cellular components, including perineuronal net; postsynaptic membrane; and ruffle membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Biomarker of amyotrophic lateral sclerosis; middle cerebral artery infarction; status epilepticus; and temporal lobe epilepsy. Orthologous to human PTPRZ1 (protein tyrosine phosphatase receptor type Z1). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Brain (RPKM 248.4) and Thymus (RPKM 10.1) See more
Orthologs: all
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Genomic context

Location:: 4q22

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (52363006..52560905)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (51397316..51595220)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High PTPRZ1 expression is associated with glioblastoma.
Title: Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells.
tenascin-C and phosphacan represent early indicators of neurodegeneration.
Title: Early remodelling of the extracellular matrix proteins tenascin-C and phosphacan in retina and optic nerve of an experimental autoimmune glaucoma model.
The intracellular delivery of SCB4380 by liposome carriers inhibited PTPRZ activity in C6 glioblastoma cells, and thereby suppressed their migration and proliferation in vitro and tumor growth in a rat allograft model.
Title: Small-molecule inhibition of PTPRZ reduces tumor growth in a rat model of glioblastoma.
deformities caused by mechanical loading, and their expression depends on the type and severity of the applied strain.
Title: Effects of mechanical loading on the expression of pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta in a rat spinal deformity model.
MK and its receptor, protein tyrosine phosphatase receptor-type Z (Ptprz1), are present in the adult rat pituitary
Title: Expression of the heparin-binding growth factor midkine and its receptor, Ptprz1, in adult rat pituitary.
Thus, the present study demonstrates that two transmembranous RPTPzeta isoforms have different functions for regulating dendritogenesis and synaptogenesis.
Title: Functional difference of receptor-type protein tyrosine phosphatase zeta/beta isoforms in neurogenesis of hippocampal neurons.
the cleavage sites in the extracellular juxtamembrane region of Ptprz by tumor necrosis factor-alpha converting enzyme and matrix metalloproteinase 9.
Title: Metalloproteinase- and gamma-secretase-mediated cleavage of protein-tyrosine phosphatase receptor type Z.
Oxidative stress can induce genomic amplification of ptprz1, activating beta-catenin pathways without the involvement of Wnt signaling for carcinogenesis.
Title: Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway.
RPTPzeta/beta is localized mainly at the postsynaptic membrane of pyramidal neurons in adult cerebral cortex and hippocampus
Title: Synaptic localization of receptor-type protein tyrosine phosphatase zeta/beta in the cerebral and hippocampal neurons of adult rats.
findings suggest that PTN-PTPzeta signaling regulates the morphogenesis of Purkinje cell dendrites and that the mechanisms underlying that regulation involve the GLAST activity in Bergmann glial processes.
Title: A chondroitin sulfate proteoglycan PTPzeta /RPTPbeta regulates the morphogenesis of Purkinje cell dendrites in the developing cerebellum.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:498441 (e-PCR)
- UniSTS:498441

Ptprz1 (e-PCR), detects polymorphism
- UniSTS:498441

RH144069 (e-PCR)
- UniSTS:233315

BF386063 (e-PCR)
- UniSTS:243564

AW521233 (e-PCR)
- UniSTS:249710

RH137971 (e-PCR)
- UniSTS:220058

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fibroblast growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in axonal fasciculation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in learning or memory	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell-substrate adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of dendrite development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron development	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligodendrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in oligodendrocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-tyrosine dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Schwann cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dendrite development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fibroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in regulation of myelination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of oligodendrocyte progenitor proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of oligodendrocyte progenitor proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in visual learning	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perineuronal net	IDA Inferred from Direct Assay more info	PubMed
located_in perineuronal net	IEA Inferred from Electronic Annotation more info
located_in perineuronal net	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase zeta

Names: 3F8 chondroitin sulfate proteoglycan; 3H1 keratan sulfate proteoglycan; 6B4 proteoglycan; PTP zeta; R-PTP-zeta; protein tyrosine phosphatase, receptor-type, Z polypeptide 1

NP_001164156.1

EC 3.1.3.48

NP_037212.2

EC 3.1.3.48

XP_006236199.1

EC 3.1.3.48

XP_006236200.1

EC 3.1.3.48

XP_006236201.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170685.1 → NP_001164156.1 receptor-type tyrosine-protein phosphatase zeta isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2), known as phosphacan, differs in the 3' UTR and 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

JAXUCZ010000004, U04998

Conserved Domains (2) summary

cd03122
Location:45 → 298

alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...

pfam00041
Location:313 → 401

fn3; Fibronectin type III domain
NM_013080.2 → NP_037212.2 receptor-type tyrosine-protein phosphatase zeta isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BE104455, JAXUCZ010000004, U09357

UniProtKB/Swiss-Prot

Q62621, Q62656

UniProtKB/TrEMBL

F1LMY3

Related

ENSRNOP00000008719.6, ENSRNOT00000008719.7

Conserved Domains (4) summary

smart00194
Location:1717 → 1992

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:1753 → 1992

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd03122
Location:45 → 298

alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...

pfam00041
Location:313 → 401

fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

52363006..52560905

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006236137.5 → XP_006236199.1 receptor-type tyrosine-protein phosphatase zeta isoform X1

UniProtKB/Swiss-Prot

Q62621, Q62656

Conserved Domains (4) summary

smart00194
Location:1717 → 1985

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:1746 → 1985

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd03122
Location:45 → 298

alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...

pfam00041
Location:313 → 401

fn3; Fibronectin type III domain
XM_006236138.5 → XP_006236200.1 receptor-type tyrosine-protein phosphatase zeta isoform X2

Conserved Domains (4) summary

smart00194
Location:864 → 1139

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:900 → 1139

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd03122
Location:45 → 298

alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...

pfam00041
Location:313 → 401

fn3; Fibronectin type III domain
XM_006236139.5 → XP_006236201.1 receptor-type tyrosine-protein phosphatase zeta isoform X3

Conserved Domains (4) summary

smart00194
Location:864 → 1132

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:893 → 1132

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd03122
Location:45 → 298

alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...

pfam00041
Location:313 → 401

fn3; Fibronectin type III domain