Format

Send to:

Choose Destination

SYCE2 synaptonemal complex central element protein 2 [ Homo sapiens (human) ]

Gene ID: 256126, updated on 9-Aug-2020

Summary

Official Symbol
SYCE2provided by HGNC
Official Full Name
synaptonemal complex central element protein 2provided by HGNC
Primary source
HGNC:HGNC:27411
See related
Ensembl:ENSG00000161860 MIM:611487
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CESC1
Summary
The protein encoded by this gene is part of the synaptonemal complex formed between homologous chromosomes during meiotic prophase. The encoded protein associates with SYCP1 and SYCE1 and is found only where chromosome cores are synapsed. [provided by RefSeq, Dec 2012]
Expression
Broad expression in testis (RPKM 7.5), liver (RPKM 2.0) and 18 other tissues See more
Orthologs

Genomic context

See SYCE2 in Genome Data Viewer
Location:
19p13.13
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (12898229..12919674, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (13009894..13030116, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-FlowFISH-validated KLF1 regulatory element Neighboring gene glutaryl-CoA dehydrogenase Neighboring gene ribosomal protein S6 pseudogene 25 Neighboring gene CRISPRi-FlowFISH-validated KLF1 regulatory element Neighboring gene microRNA 5695 Neighboring gene phenylalanyl-tRNA synthetase subunit alpha Neighboring gene FARSA antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
NHGRI GWA Catalog
Seventy-five genetic loci influencing the human red blood cell.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
synaptonemal complex assembly NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
central element IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
central element ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
synaptonemal complex central element protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033049.1 RefSeqGene

    Range
    4980..25487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001105578.2NP_001099048.1  synaptonemal complex central element protein 2

    See identical proteins and their annotated locations for NP_001099048.1

    Status: REVIEWED

    Source sequence(s)
    AC092069, AD000092, BC035819, DB449708
    Consensus CDS
    CCDS42509.1
    UniProtKB/Swiss-Prot
    Q6PIF2
    Related
    ENSP00000293695.6, ENST00000293695.8
    Conserved Domains (2) summary
    pfam07307
    Location:48116
    HEPPP_synt_1; Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1
    pfam16566
    Location:96148
    CREPT; Cell-cycle alteration and expression-elevated protein in tumour

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    12898229..12919674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527882.2XP_011526184.1  synaptonemal complex central element protein 2 isoform X1

    Conserved Domains (2) summary
    pfam07307
    Location:48116
    HEPPP_synt_1; Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1
    pfam16566
    Location:96148
    CREPT; Cell-cycle alteration and expression-elevated protein in tumour
  2. XM_011527883.2XP_011526185.1  synaptonemal complex central element protein 2 isoform X3

    Conserved Domains (2) summary
    pfam07307
    Location:48116
    HEPPP_synt_1; Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1
    pfam16566
    Location:96148
    CREPT; Cell-cycle alteration and expression-elevated protein in tumour
  3. XM_005259848.4XP_005259905.1  synaptonemal complex central element protein 2 isoform X2

    Conserved Domains (2) summary
    pfam07307
    Location:48116
    HEPPP_synt_1; Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1
    pfam16566
    Location:96148
    CREPT; Cell-cycle alteration and expression-elevated protein in tumour
Support Center