Format

Send to:

Choose Destination

Asns asparagine synthetase (glutamine-hydrolyzing) [ Rattus norvegicus (Norway rat) ]

Gene ID: 25612, updated on 12-Jan-2022

Summary

Official Symbol
Asnsprovided by RGD
Official Full Name
asparagine synthetase (glutamine-hydrolyzing)provided by RGD
Primary source
RGD:2162
See related
Ensembl:ENSRNOG00000007546
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables asparagine synthase (glutamine-hydrolyzing) activity and identical protein binding activity. Involved in several processes, including asparagine biosynthetic process; cellular response to glucose starvation; and response to follicle-stimulating hormone. Predicted to be active in cytosol. Biomarker of hepatocellular carcinoma. Orthologous to human ASNS (asparagine synthetase (glutamine-hydrolyzing)). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Spleen (RPKM 212.2), Testes (RPKM 153.7) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Asns in Genome Data Viewer
Location:
4q21
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (35784995..35803474, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (33742876..33761106, complement)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene protein SET-like Neighboring gene uncharacterized LOC120102233 Neighboring gene DNA-directed RNA polymerases I and III subunit RPAC2-like Neighboring gene core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC93148

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in L-asparagine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in asparagine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in asparagine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within asparagine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular amino acid metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to glucose starvation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in glutamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in liver development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in response to amino acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to follicle-stimulating hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to light stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to toxic substance IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
asparagine synthetase [glutamine-hydrolyzing]
Names
glutamine-dependent asparagine synthetase
NP_037211.2
XP_006236151.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013079.2NP_037211.2  asparagine synthetase [glutamine-hydrolyzing]

    See identical proteins and their annotated locations for NP_037211.2

    Status: PROVISIONAL

    Source sequence(s)
    BC081719
    UniProtKB/Swiss-Prot
    P49088
    Conserved Domains (1) summary
    PRK09431
    Location:1560
    asnB; asparagine synthetase B; Provisional

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    35784995..35803474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236089.4XP_006236151.1  asparagine synthetase [glutamine-hydrolyzing] isoform X1

    See identical proteins and their annotated locations for XP_006236151.1

    UniProtKB/Swiss-Prot
    P49088
    Related
    ENSRNOP00000010079.3, ENSRNOT00000010079.5
    Conserved Domains (1) summary
    PRK09431
    Location:1560
    asnB; asparagine synthetase B; Provisional
Support Center