U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Csf3 colony stimulating factor 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25610, updated on 5-Mar-2024

Summary

Official Symbol
Csf3provided by RGD
Official Full Name
colony stimulating factor 3provided by RGD
Primary source
RGD:2426
See related
Ensembl:ENSRNOG00000008525 AllianceGenome:RGD:2426
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gcsf
Summary
Enables growth factor activity. Involved in several processes, including cellular response to lipopolysaccharide; negative regulation of neuron death; and response to ethanol. Located in extracellular space. Biomarker of cystitis; lung disease; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in several diseases, including allergic cutaneous vasculitis; artery disease (multiple); ischemia (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to human CSF3 (colony stimulating factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Uterus (RPKM 4.7), Thymus (RPKM 0.4) and 2 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Csf3 in Genome Data Viewer
Location:
10q31
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (84157485..84159860)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83660787..83664569)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86616785..86619160)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene gasdermin A Neighboring gene proteasome 26S subunit, non-ATPase 3 Neighboring gene small nucleolar RNA SNORD124 Neighboring gene mediator complex subunit 24 Neighboring gene thyroid hormone receptor alpha Neighboring gene nuclear receptor subfamily 1, group D, member 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables granulocyte colony-stimulating factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables granulocyte colony-stimulating factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in granulocyte colony-stimulating factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of myeloid cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin filament organization ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
granulocyte colony-stimulating factor
Names
colony stimulating factor 3 (granulocyte)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017104.2NP_058800.2  granulocyte colony-stimulating factor precursor

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000220
    UniProtKB/TrEMBL
    A6HIT8, F7FGY7
    Related
    ENSRNOP00000011509.4, ENSRNOT00000011509.4
    Conserved Domains (1) summary
    cl02473
    Location:48196
    IL6; Interleukin-6/G-CSF/MGF family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    84157485..84159860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)