Csf3 colony stimulating factor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Csf3provided by RGD
Official Full Name: colony stimulating factor 3provided by RGD
Primary source: RGD:2426
See related: Ensembl:ENSRNOG00000008525
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gcsf
Summary: putative hematopoetic growth factor for neutrophils; used as a treatment for cyclic hematopoesis in humans and dogs [RGD, Feb 2006]
Expression: Biased expression in Uterus (RPKM 4.7), Thymus (RPKM 0.4) and 2 other tissues See more
Orthologs: human mouse all

Genomic context

Location:: 10q31

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (86616785..86619160)
104	previous assembly	Rnor_5.0 (GCF_000001895.4)	10	NC_005109.3 (86413088..86415478)

Chromosome 10 - NC_005109.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

findings demonstrated that the administration of exogenous G-CSF can improve cognitive function in a model of Cerebral small vessel diseases, possibly due to the recovery of endothelial and Blood Brain Barrier function.
Title: Granulocyte Colony-Stimulating Factor Attenuates Blood-Brain Barrier Damage and Improves Cognitive Function in Spontaneously Hypertensive Rats.
G-CSF treatment reduced body weight and increased energy expenditure in a diabetic model, and enhanced UCP-1 expression and decreased inflammatory cytokine levels may be associated with the effects of G-CSF treatment.
Title: Anti-obesity effects of granulocyte-colony stimulating factor in Otsuka-Long-Evans-Tokushima fatty rats.
The use of G-CSF to protect the vasculature may improve the clinical outcome of tPA even outside the currently indicated therapeutic window for ischemic stroke.
Title: Granulocyte colony-stimulating factor attenuates delayed tPA-induced hemorrhagic transformation in ischemic stroke rats by enhancing angiogenesis and vasculogenesis.
G-CSF can prevent the progression of DN in OLETF rats and its effects may be due to mobilization of BM cells rather than being a direct effect.
Title: G-CSF prevents progression of diabetic nephropathy in rat.
In conclusion, G-CSF induced LBP expression could serve as a new model for investigation of LPS sensitization. We demonstrated the crucial role of LBP upregulation in pathogenesis of LPS induced SIRS.
Title: Granulocyte colony stimulating factor induces lipopolysaccharide (LPS) sensitization via upregulation of LPS binding protein in rat.
G-CSF protects oligodendrocyte from SCI-induced cell death via the suppression of inflammatory cytokines and up-regulation of anti-apoptotic protein
Title: Granulocyte colony-stimulating factor (G-CSF) protects oligodendrocyte and promotes hindlimb functional recovery after spinal cord injury in rats.
G-CSF has an influence on the stability of presynaptic terminals in the spinal cord as well as on the astroglial reaction, indicating a possible neuroprotective action.
Title: Granulocyte colony stimulating factor neuroprotective effects on spinal motoneurons after ventral root avulsion.
These findings extend current knowledge regarding the role of SCF and G-CSF in the regulation of neurogenesis and provide insights into the contribution of hematopoietic growth factors to brain development and remodeling
Title: Stem cell factor and granulocyte colony-stimulating factor promote neuronal lineage commitment of neural stem cells.
Granulocyte-colony stimulating factor (G-CSF) facilitates hepatic regeneration by increasing the migration of bone marrow progenitors to the liver, as well as enhancing the endogenous oval cell reaction.
Title: Granulocyte-colony stimulating factor promotes liver repair and induces oval cell migration and proliferation in rats.
Epo combined with granulocyte colonystimulating factor enhanced Mmp2 expression in mesenchymal stem cells, promoted motility and activated the ERK1/2 signaling pathway.
Title: Erythropoietin combined with granulocyte colony‑stimulating factor enhances MMP-2 expression in mesenchymal stem cells and promotes cell migration.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from BioSystems

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Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokines and Inflammatory Response (BioCarta), organism-specific biosystem (from WikiPathways)
Cytokines and Inflammatory Response (BioCarta), organism-specific biosystemSee BioCarta version: http://www.biocarta.com/pathfiles/h_inflamPathway.asp
Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
Hematopoietic cell lineage, conserved biosystem (from KEGG)
Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
IL-17 signaling pathway, organism-specific biosystem (from KEGG)
IL-17 signaling pathway, organism-specific biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
IL-17 signaling pathway, conserved biosystem (from KEGG)
IL-17 signaling pathway, conserved biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Jak-STAT signaling pathway, conserved biosystem (from KEGG)
Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Malaria, organism-specific biosystem (from KEGG)
Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
Malaria, conserved biosystem (from KEGG)
Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
Signaling by Interleukins, organism-specific biosystem (from REACTOME)
Signaling by Interleukins, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

RH94653 (e-PCR)
- UniSTS:119900

PMC316809P1 (e-PCR)
- UniSTS:273048

Homology

Homologs of the Csf3 gene: The Csf3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, and chicken.
Orthologs from Annotation Pipeline: 173 organisms have orthologs with human gene Csf3
Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
cytokine activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cytokine activity	ISO Inferred from Sequence Orthology more info	PubMed
enzyme binding	IEA Inferred from Electronic Annotation more info
enzyme binding	ISO Inferred from Sequence Orthology more info	PubMed
granulocyte colony-stimulating factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
granulocyte colony-stimulating factor receptor binding	ISO Inferred from Sequence Orthology more info	PubMed
growth factor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
growth factor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
cellular response to cytokine stimulus	IEA Inferred from Electronic Annotation more info
cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info	PubMed
cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
immune response	IEA Inferred from Electronic Annotation more info
negative regulation of neuron death	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info	PubMed
positive regulation of actin cytoskeleton reorganization	IEA Inferred from Electronic Annotation more info
positive regulation of actin cytoskeleton reorganization	ISO Inferred from Sequence Orthology more info	PubMed
positive regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info	PubMed
positive regulation of cell proliferation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of myeloid cell differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of myeloid cell differentiation	ISO Inferred from Sequence Orthology more info	PubMed
positive regulation of peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
positive regulation of phosphatidylinositol 3-kinase signaling	IEA Inferred from Electronic Annotation more info
positive regulation of phosphatidylinositol 3-kinase signaling	ISO Inferred from Sequence Orthology more info	PubMed
positive regulation of protein binding	IEA Inferred from Electronic Annotation more info
positive regulation of protein binding	ISO Inferred from Sequence Orthology more info	PubMed
positive regulation of protein kinase B signaling	IEA Inferred from Electronic Annotation more info
positive regulation of protein kinase B signaling	ISO Inferred from Sequence Orthology more info	PubMed
positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info	PubMed
regulation of signaling receptor activity	IEA Inferred from Electronic Annotation more info
response to ethanol	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: granulocyte colony-stimulating factor

Names: colony stimulating factor 3 (granulocyte)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017104.2 → NP_058800.2 granulocyte colony-stimulating factor precursor

Status: VALIDATED

Source sequence(s)

AC119462

Related

ENSRNOP00000011509.3, ENSRNOT00000011509.3

Conserved Domains (1) summary

cl02473
Location:48 → 196

IL6; Interleukin-6/G-CSF/MGF family