U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lep leptin [ Rattus norvegicus (Norway rat) ]

Gene ID: 25608, updated on 24-Apr-2022

Summary

Official Symbol
Lepprovided by RGD
Official Full Name
leptinprovided by RGD
Primary source
RGD:3000
See related
Ensembl:ENSRNOG00000045797 AllianceGenome:RGD:3000
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
OB; obese
Summary
Enables hormone activity and peptide hormone receptor binding activity. Involved in several processes, including positive regulation of cell communication; regulation of apoptotic process; and response to vitamin. Located in cytosol and extracellular space. Used to study several diseases, including alcohol dependence; glucose metabolism disease (multiple); liver disease (multiple); neurodegenerative disease (multiple); and short bowel syndrome. Biomarker of several diseases, including Huntington's disease; alcohol dependence; fatty liver disease (multiple); lipid metabolism disorder (multiple); and obesity. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; fatty liver disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human LEP (leptin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 108.2), Thymus (RPKM 61.6) and 5 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Lep in Genome Data Viewer
Location:
4q22
Exon count:
3
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (57661127..57675262)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (56337695..56351818)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102250 Neighboring gene TIMP metallopeptidase inhibitor 1, pseudogene 1 Neighboring gene microRNA 129-1 Neighboring gene RNA binding motif protein 28 Neighboring gene proline-rich transmembrane protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables cytokine activity TAS
Traceable Author Statement
more info
PubMed 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
enables leptin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables peptide hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in activation of protein kinase C activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in activation of protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of protein kinase C activity ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within adipose tissue development ISO
Inferred from Sequence Orthology
more info
 
involved_in adult feeding behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in adult feeding behavior ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within aorta development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within bile acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in bone growth ISO
Inferred from Sequence Orthology
more info
 
involved_in bone growth ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in bone mineralization involved in bone maturation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cAMP-mediated signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in cardiac muscle hypertrophy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to L-ascorbic acid IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to leptin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within central nervous system neuron development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within determination of adult lifespan ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within eating behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within elastin metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in energy reserve metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in energy reserve metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glycerol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within hormone metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in intestinal absorption ISO
Inferred from Sequence Orthology
more info
 
involved_in intestinal absorption ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in leptin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leptin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte tethering or rolling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipid metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of appetite ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of appetite ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of appetite by leptin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of appetite by leptin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cartilage development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of glucagon secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glucose import ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of glutamine transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipid storage IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vasoconstriction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ovulation from ovarian follicle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in placenta development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of cytokine production IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of developmental growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fat cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of follicle-stimulating hormone secretion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of hepatic stellate cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-12 production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of luteinizing hormone secretion IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within positive regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of p38MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of p38MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in prostaglandin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in prostaglandin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in receptor signaling pathway via JAK-STAT TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of bone remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of bone remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of brown fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytokine production involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of endothelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of intestinal cholesterol absorption ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of lipoprotein lipid oxidation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of natural killer cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of natural killer cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of natural killer cell mediated cytotoxicity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of natural killer cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of natural killer cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of nitric-oxide synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to dietary excess IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to dietary excess ISO
Inferred from Sequence Orthology
more info
 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to insulin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within response to insulin ISO
Inferred from Sequence Orthology
more info
 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to vitamin E IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in sexual reproduction ISO
Inferred from Sequence Orthology
more info
 
involved_in tyrosine phosphorylation of STAT protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
leptin
Names
obesity factor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013076.3NP_037208.1  leptin precursor

    See identical proteins and their annotated locations for NP_037208.1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000141
    UniProtKB/Swiss-Prot
    P50596
    Related
    ENSRNOP00000066184.1, ENSRNOT00000071926.2
    Conserved Domains (1) summary
    pfam02024
    Location:26167
    Leptin

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    57661127..57675262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107126.1XP_038963054.1  leptin isoform X1

    Conserved Domains (1) summary
    pfam02024
    Location:26166
    Leptin