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Marcks myristoylated alanine rich protein kinase C substrate [ Rattus norvegicus (Norway rat) ]

Gene ID: 25603, updated on 2-May-2024

Summary

Symbol
Marcksprovided by RGD
Full Name
myristoylated alanine rich protein kinase C substrateprovided by RGD
Primary source
RGD:3028
See related
Ensembl:ENSRNOG00000000579 AllianceGenome:RGD:3028
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
KINC; Macs
Summary
Enables phosphatidylserine binding activity. Involved in several processes, including activation of phospholipase D activity; positive regulation of protein kinase C activity; and regulation of synapse organization. Located in several cellular components, including bleb; dendrite; and distal axon. Is active in glutamatergic synapse; postsynaptic cytoskeleton; and presynaptic cytosol. Is anchored component of postsynaptic membrane and anchored component of presynaptic membrane. Colocalizes with microtubule. Biomarker of visual epilepsy. Orthologous to human MARCKS (myristoylated alanine rich protein kinase C substrate). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 776.1), Spleen (RPKM 725.4) and 9 other tissues See more
Orthologs
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Genomic context

See Marcks in Genome Data Viewer
Location:
20q12
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (42240185..42245882, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (40685315..40691012, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (42966140..42971838)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene SET domain bifurcated histone lysine methyltransferase 2, pseudogene 1 Neighboring gene uncharacterized LOC134483816 Neighboring gene uncharacterized LOC120098996 Neighboring gene uncharacterized LOC120098880

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylserine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase C binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin crosslink formation IEA
Inferred from Electronic Annotation
more info
 
involved_in actin crosslink formation ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament bundle assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-substrate adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrion organization IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
involved_in neural tube development IEA
Inferred from Electronic Annotation
more info
 
involved_in neural tube development ISO
Inferred from Sequence Orthology
more info
 
involved_in neurogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in neurogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of modification of postsynaptic actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of modification of postsynaptic actin cytoskeleton IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular cardiac muscle tissue development IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in actin filament bundle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in actin filament bundle IEA
Inferred from Electronic Annotation
more info
 
located_in actin filament bundle ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus IDA
Inferred from Direct Assay
more info
PubMed 
located_in bleb IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromatoid body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic branch IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in germinal vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in germinal vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in organelle ISO
Inferred from Sequence Orthology
more info
 
located_in outer dense fiber IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic membrane EXP
Inferred from Experiment
more info
PubMed 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic cytosol EXP
Inferred from Experiment
more info
PubMed 
is_active_in presynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane EXP
Inferred from Experiment
more info
PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
myristoylated alanine-rich C-kinase substrate
Names
Myristoylated alanine-rich protein kinase C substrate
protein kinase C substrate 80 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271090.3NP_001258019.2  myristoylated alanine-rich C-kinase substrate

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/Swiss-Prot
    P20468, P30009
    UniProtKB/TrEMBL
    F1LMW7
    Related
    ENSRNOP00000000707.7, ENSRNOT00000000707.7
    Conserved Domains (1) summary
    pfam02063
    Location:2305
    MARCKS; MARCKS family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    42240185..42245882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)