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Ppp1cb protein phosphatase 1 catalytic subunit beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 25594, updated on 30-Sep-2021

Summary

Official Symbol
Ppp1cbprovided by RGD
Official Full Name
protein phosphatase 1 catalytic subunit betaprovided by RGD
Primary source
RGD:3376
See related
EnsemblRapid:ENSRNOG00000004612
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PP1B; PP1beta
Summary
one of several neuronal isoforms of protein phosphatase 1 [RGD, Feb 2006]
Expression
Biased expression in Muscle (RPKM 1634.0), Heart (RPKM 1018.2) and 9 other tissues See more
Orthologs
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Genomic context

See Ppp1cb in Genome Data Viewer
Location:
6q13
Exon count:
8
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (23958813..23992841, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (23548507..23581136, complement)

Chromosome 6 - NC_051341.1Genomic Context describing neighboring genes Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene speedy/RINGO cell cycle regulator family member A Neighboring gene uncharacterized LOC120103485 Neighboring gene phospholipase B1 Neighboring gene uncharacterized LOC120103486

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables myosin-light-chain-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables myosin-light-chain-phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
 
enables protein threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in entrainment of circadian clock by photoperiod ISO
Inferred from Sequence Orthology
more info
 
involved_in entrainment of circadian clock by photoperiod ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of glycogen biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of glycogen catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of PTW/PP1 phosphatase complex ISO
Inferred from Sequence Orthology
more info
 
part_of PTW/PP1 phosphatase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in glycogen granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein phosphatase type 1 complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase PP1-beta catalytic subunit
Names
PP-1B
protein phosphatase 1, catalytic subunit, beta isozyme
protein phosphatase-1a
NP_037197.1
XP_008762727.1
XP_038967740.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013065.2NP_037197.1  serine/threonine-protein phosphatase PP1-beta catalytic subunit

    See identical proteins and their annotated locations for NP_037197.1

    Status: PROVISIONAL

    Source sequence(s)
    BC062033
    UniProtKB/Swiss-Prot
    P62142
    Related
    ENSRNOP00000091459.1, ENSRNOT00000119348.1
    Conserved Domains (1) summary
    cd07414
    Location:7297
    MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051341.1 Reference mRatBN7.2 Primary Assembly

    Range
    23958813..23992841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764505.3XP_008762727.1  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1

    See identical proteins and their annotated locations for XP_008762727.1

    UniProtKB/Swiss-Prot
    P62142
    Related
    ENSRNOP00000006190.3, ENSRNOT00000006190.5
    Conserved Domains (1) summary
    cd07414
    Location:7297
    MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
  2. XM_039111812.1XP_038967740.1  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X2

    Conserved Domains (1) summary
    cl13995
    Location:7197
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
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