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Kdr kinase insert domain receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 25589, updated on 28-Oct-2019

Summary

Official Symbol
Kdrprovided by RGD
Official Full Name
kinase insert domain receptorprovided by RGD
Primary source
RGD:2965
See related
Ensembl:ENSRNOG00000046829
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Vegfr-2
Summary
receptor for vascular endothelial growth factor (VEGF) [RGD, Feb 2006]
Annotation information
Annotation category: partial on reference assembly
Expression
Biased expression in Lung (RPKM 646.5), Adrenal (RPKM 253.7) and 8 other tissues See more
Orthologs

Genomic context

See Kdr in Genome Data Viewer
Location:
14p11
Exon count:
30
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (34727677..34787127)
106 current Rn_Celera (GCF_000002265.2) 14 AC_000082.1 (31512534..31554989)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 14 NC_005113.3 (34557361..34618112)

Chromosome 14 - NC_005113.4Genomic Context describing neighboring genes Neighboring gene transmembrane protein 165 Neighboring gene steroid 5 alpha-reductase 3 Neighboring gene uncharacterized LOC102553643 Neighboring gene KIT proto-oncogene receptor tyrosine kinase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • EGFR tyrosine kinase inhibitor resistance, organism-specific biosystem (from KEGG)
    EGFR tyrosine kinase inhibitor resistance, organism-specific biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
  • EGFR tyrosine kinase inhibitor resistance, conserved biosystem (from KEGG)
    EGFR tyrosine kinase inhibitor resistance, conserved biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
  • EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
    EPH-Ephrin signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • EPHA-mediated growth cone collapse, organism-specific biosystem (from REACTOME)
    EPHA-mediated growth cone collapse, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
  • Neurophilin interactions with VEGF and VEGFR, organism-specific biosystem (from REACTOME)
    Neurophilin interactions with VEGF and VEGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by VEGF, organism-specific biosystem (from REACTOME)
    Signaling by VEGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • VEGF binds to VEGFR leading to receptor dimerization, organism-specific biosystem (from REACTOME)
    VEGF binds to VEGFR leading to receptor dimerization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • VEGF ligand-receptor interactions, organism-specific biosystem (from REACTOME)
    VEGF ligand-receptor interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • VEGF signaling pathway, organism-specific biosystem (from KEGG)
    VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
  • VEGF signaling pathway, conserved biosystem (from KEGG)
    VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
  • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
    VEGFA-VEGFR2 Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • VEGFR2 mediated cell proliferation, organism-specific biosystem (from REACTOME)
    VEGFR2 mediated cell proliferation, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

Markers

Homology

Clone Names

  • MGC93590

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cadherin binding IEA
Inferred from Electronic Annotation
more info
 
cadherin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
growth factor binding IEA
Inferred from Electronic Annotation
more info
 
growth factor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
growth factor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
integrin binding IEA
Inferred from Electronic Annotation
more info
 
integrin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vascular endothelial growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vascular endothelial growth factor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
vascular endothelial growth factor-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vascular endothelial growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
vascular endothelial growth factor-activated receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
vascular endothelial growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
branching morphogenesis of an epithelial tube ISO
Inferred from Sequence Orthology
more info
PubMed 
calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
PubMed 
calcium-mediated signaling using intracellular calcium source IEA
Inferred from Electronic Annotation
more info
 
calcium-mediated signaling using intracellular calcium source ISO
Inferred from Sequence Orthology
more info
PubMed 
calcium-mediated signaling using intracellular calcium source ISS
Inferred from Sequence or Structural Similarity
more info
 
cell fate commitment ISO
Inferred from Sequence Orthology
more info
PubMed 
cell maturation ISO
Inferred from Sequence Orthology
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to hydrogen sulfide IEA
Inferred from Electronic Annotation
more info
 
cellular response to hydrogen sulfide ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to vascular endothelial growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic hemopoiesis ISO
Inferred from Sequence Orthology
more info
PubMed 
embryonic hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
 
endocardium development ISO
Inferred from Sequence Orthology
more info
PubMed 
endochondral bone growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
endothelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
endothelium development ISO
Inferred from Sequence Orthology
more info
PubMed 
endothelium development ISS
Inferred from Sequence or Structural Similarity
more info
 
hemopoiesis ISO
Inferred from Sequence Orthology
more info
PubMed 
hyaluronan metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
lung alveolus development ISO
Inferred from Sequence Orthology
more info
PubMed 
lung development ISO
Inferred from Sequence Orthology
more info
PubMed 
lymph vessel development ISO
Inferred from Sequence Orthology
more info
PubMed 
male gonad development IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of endothelial cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
ovarian follicle development ISO
Inferred from Sequence Orthology
more info
PubMed 
peptidyl-tyrosine autophosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of blood vessel diameter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of endothelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of focal adhesion assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of macroautophagy IEA
Inferred from Electronic Annotation
more info
 
positive regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of mitochondrial depolarization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of mitochondrial fission IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of neurogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of nitric-oxide synthase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of nitric-oxide synthase biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of vasculogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of vasculogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
post-embryonic camera-type eye morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of bone development ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
response to drug IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to oxygen levels IEP
Inferred from Expression Pattern
more info
PubMed 
sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
surfactant homeostasis ISO
Inferred from Sequence Orthology
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
vasculogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
PubMed 
cell IEA
Inferred from Electronic Annotation
more info
 
cell junction ISO
Inferred from Sequence Orthology
more info
PubMed 
cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
cell periphery ISO
Inferred from Sequence Orthology
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
early endosome IEA
Inferred from Electronic Annotation
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
PubMed 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sorting endosome ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
vascular endothelial growth factor receptor 2
Names
FLK-1
FLK1 kinase insert domain receptor (VEGF receptor 2)
FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2)
fetal liver kinase 1
kinase insert domain protein receptor
protein-tyrosine kinase receptor flk-1
NP_037194.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013062.1NP_037194.1  vascular endothelial growth factor receptor 2 precursor

    See identical proteins and their annotated locations for NP_037194.1

    Status: PROVISIONAL

    Source sequence(s)
    U93306
    UniProtKB/Swiss-Prot
    O08775
    Related
    ENSRNOP00000066886.2, ENSRNOT00000071405.2
    Conserved Domains (6) summary
    smart00408
    Location:676740
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:670746
    IG_like; Immunoglobulin like
    cd05103
    Location:8221163
    PTKc_VEGFR2; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2
    pfam07714
    Location:8301156
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13895
    Location:547648
    Ig_2; Immunoglobulin domain
    cl11960
    Location:239325
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005113.4 Reference Rnor_6.0 Primary Assembly

    Range
    34727677..34787127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000082.1 Alternate Rn_Celera

    Range
    31512534..31554989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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