U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Id2 inhibitor of DNA binding 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25587, updated on 27-Nov-2024

Summary

Official Symbol
Id2provided by RGD
Official Full Name
inhibitor of DNA binding 2provided by RGD
Primary source
RGD:2859
See related
EnsemblRapid:ENSRNOG00000007237 AllianceGenome:RGD:2859
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ac2-300
Summary
Predicted to enable several functions, including transcription corepressor activity; transcription regulator inhibitor activity; and transmembrane transporter binding activity. Involved in several processes, including cellular response to follicle-stimulating hormone stimulus; negative regulation of macromolecule biosynthetic process; and positive regulation of cell population proliferation. Located in chromatin; cytoplasm; and nucleus. Orthologous to human ID2 (inhibitor of DNA binding 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 625.8), Kidney (RPKM 579.8) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Id2 in Genome Data Viewer
Location:
6q16
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (47469162..47470995, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (41740556..41742393, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (44360077..44361908, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene kinase D-interacting substrate 220 Neighboring gene ubiquinol-cytochrome-c reductase complex assembly factor 3-like Neighboring gene uncharacterized LOC134479282 Neighboring gene uncharacterized LOC102553989

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC105494

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription regulator inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Peyer's patch development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adipose tissue development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adult locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within bundle of His development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell maturation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell morphogenesis involved in neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to follicle-stimulating hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to lithium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular senescence ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of dopaminergic neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic digestive tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic digestive tract morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endodermal digestive tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in endodermal digestive tract morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within entrainment of circadian clock ISO
Inferred from Sequence Orthology
more info
 
involved_in entrainment of circadian clock by photoperiod ISO
Inferred from Sequence Orthology
more info
 
involved_in entrainment of circadian clock by photoperiod ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within enucleate erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell differentiation involved in mammary gland alveolus development ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell differentiation involved in mammary gland alveolus development ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within leukocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in locomotor rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in locomotor rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mammary gland alveolus development ISO
Inferred from Sequence Orthology
more info
 
involved_in mammary gland alveolus development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mammary gland epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in mammary gland epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in membranous septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within metanephros development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within natural killer cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of dopaminergic neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuron differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of neuron fate commitment ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of neuron fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within olfactory bulb development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within oligodendrocyte development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_negative_effect regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_negative_effect regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_negative_effect regulation of neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_negative_effect regulation of neural precursor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_negative_effect regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_negative_effect regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within thigmotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of white fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in euchromatin ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
DNA-binding protein inhibitor ID-2
Names
inhibitor of DNA binding 2, HLH protein
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
inhibitor of differentiation 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013060.4NP_037192.1  DNA-binding protein inhibitor ID-2

    See identical proteins and their annotated locations for NP_037192.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    P41137
    UniProtKB/TrEMBL
    A6HAZ2
    Related
    ENSRNOP00000009491.3, ENSRNOT00000009491.8
    Conserved Domains (1) summary
    cd19692
    Location:1883
    bHLH_dnHLH_ID2; basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID2 and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    47469162..47470995 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)