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Alpl alkaline phosphatase, biomineralization associated [ Rattus norvegicus (Norway rat) ]

Gene ID: 25586, updated on 25-Jan-2022

Summary

Official Symbol
Alplprovided by RGD
Official Full Name
alkaline phosphatase, biomineralization associatedprovided by RGD
Primary source
RGD:2100
See related
Ensembl:ENSRNOG00000013954 AllianceGenome:RGD:2100
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Akp2; PHOA; TNAP
Summary
Enables alkaline phosphatase activity. Involved in cementum mineralization; response to glucocorticoid; and response to lipopolysaccharide. Located in extracellular space and plasma membrane. Is active in extracellular membrane-bounded organelle. Biomarker of uremia. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; and infantile hypophosphatasia. Orthologous to human ALPL (alkaline phosphatase, biomineralization associated). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Kidney (RPKM 605.2), Lung (RPKM 229.4) and 2 other tissues See more
Orthologs
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Genomic context

See Alpl in Genome Data Viewer
Location:
5q36
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (149951397..150006424, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (156086496..156141513, complement)

Chromosome 5 - NC_051340.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 48 Neighboring gene Rap1 GTPase-activating protein Neighboring gene U4 spliceosomal RNA Neighboring gene endothelin converting enzyme 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC93545

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables adenosine-diphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables alkaline phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables alkaline phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables alkaline phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables alkaline phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables alkaline phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables inorganic diphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoamidase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphoamidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphoethanolamine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoethanolamine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables pyridoxal phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables pyridoxal phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables pyrophosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables pyrophosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in biomineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
involved_in cementum mineralization IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within developmental process involved in reproduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endochondral ossification ISO
Inferred from Sequence Orthology
more info
 
involved_in futile creatine cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organism aging ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphate ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in pyridoxal phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in pyridoxal phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to antibiotic ISO
Inferred from Sequence Orthology
more info
 
involved_in response to glucocorticoid IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to sodium phosphate ISO
Inferred from Sequence Orthology
more info
 
involved_in response to vitamin B6 ISO
Inferred from Sequence Orthology
more info
 
involved_in response to vitamin D ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrial intermembrane space ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrial membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
alkaline phosphatase, tissue-nonspecific isozyme
Names
AP-TNAP
TNSALP
Tissue-nonspecific ALP alkaline phosphatase
alkaline phosphatase 2, liver
alkaline phosphatase liver/bone/kidney isozyme
alkaline phosphatase, liver/bone/kidney
phosphoamidase
phosphocreatine phosphatase
tissue-nonspecific alkaline phosphatase
NP_037191.2
XP_006239198.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013059.2NP_037191.2  alkaline phosphatase, tissue-nonspecific isozyme precursor

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000162
    Related
    ENSRNOP00000019004.3, ENSRNOT00000019004.6
    Conserved Domains (1) summary
    pfam00245
    Location:51490
    Alk_phosphatase; Alkaline phosphatase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051340.1 Reference mRatBN7.2 Primary Assembly

    Range
    149951397..150006424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239136.4XP_006239198.1  alkaline phosphatase, tissue-nonspecific isozyme isoform X1

    See identical proteins and their annotated locations for XP_006239198.1

    UniProtKB/Swiss-Prot
    P08289
    Conserved Domains (1) summary
    pfam00245
    Location:51490
    Alk_phosphatase; Alkaline phosphatase
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