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Alpl alkaline phosphatase, biomineralization associated [ Rattus norvegicus (Norway rat) ]

Gene ID: 25586, updated on 19-Nov-2019

Summary

Official Symbol
Alplprovided by RGD
Official Full Name
alkaline phosphatase, biomineralization associatedprovided by RGD
Primary source
RGD:2100
See related
Ensembl:ENSRNOG00000013954
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Akp2; PHOA
Summary
catalyzes the conversion of an orthophosphoric monoester to an alcohol phosphate [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 605.2), Lung (RPKM 229.4) and 2 other tissues See more
Orthologs

Genomic context

See Alpl in Genome Data Viewer
Location:
5q36
Exon count:
14
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (156086496..156141513, complement)
106 current Rn_Celera (GCF_000002265.2) 5 AC_000073.1 (148347371..148402292, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (159841916..159897391, complement)

Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 48 Neighboring gene Rap1 GTPase-activating protein Neighboring gene endothelin converting enzyme 1 Neighboring gene eukaryotic translation initiation factor 4 gamma, 3 Neighboring gene uncharacterized LOC102553758

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC93545

Gene Ontology Provided by RGD

Function Evidence Code Pubs
alkaline phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
alkaline phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
alkaline phosphatase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
alkaline phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
pyrophosphatase activity IEA
Inferred from Electronic Annotation
more info
 
pyrophosphatase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
PubMed 
cementum mineralization IEP
Inferred from Expression Pattern
more info
PubMed 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
developmental process involved in reproduction IEA
Inferred from Electronic Annotation
more info
 
developmental process involved in reproduction ISO
Inferred from Sequence Orthology
more info
PubMed 
endochondral ossification IEA
Inferred from Electronic Annotation
more info
 
endochondral ossification ISO
Inferred from Sequence Orthology
more info
PubMed 
response to antibiotic IEA
Inferred from Electronic Annotation
more info
 
response to antibiotic ISO
Inferred from Sequence Orthology
more info
PubMed 
response to glucocorticoid IDA
Inferred from Direct Assay
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
response to vitamin D IEA
Inferred from Electronic Annotation
more info
 
response to vitamin D ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
extracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
alkaline phosphatase, tissue-nonspecific isozyme
Names
AP-TNAP
TNSALP
Tissue-nonspecific ALP alkaline phosphatase
alkaline phosphatase 2, liver
alkaline phosphatase liver/bone/kidney isozyme
alkaline phosphatase, liver/bone/kidney
tissue-nonspecific alkaline phosphatase
NP_037191.1
XP_006239198.1
XP_017448654.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013059.1NP_037191.1  alkaline phosphatase, tissue-nonspecific isozyme precursor

    See identical proteins and their annotated locations for NP_037191.1

    Status: PROVISIONAL

    Source sequence(s)
    J03572
    UniProtKB/Swiss-Prot
    P08289
    Related
    ENSRNOP00000019004.3, ENSRNOT00000019004.5
    Conserved Domains (1) summary
    pfam00245
    Location:51490
    Alk_phosphatase; Alkaline phosphatase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005104.4 Reference Rnor_6.0 Primary Assembly

    Range
    156086496..156141513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239136.3XP_006239198.1  alkaline phosphatase, tissue-nonspecific isozyme isoform X1

    See identical proteins and their annotated locations for XP_006239198.1

    UniProtKB/Swiss-Prot
    P08289
    Conserved Domains (1) summary
    pfam00245
    Location:51490
    Alk_phosphatase; Alkaline phosphatase
  2. XM_017593165.1XP_017448654.1  alkaline phosphatase, tissue-nonspecific isozyme isoform X1

    UniProtKB/Swiss-Prot
    P08289
    Conserved Domains (1) summary
    pfam00245
    Location:51490
    Alk_phosphatase; Alkaline phosphatase

Alternate Rn_Celera

Genomic

  1. AC_000073.1 Alternate Rn_Celera

    Range
    148347371..148402292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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