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SMCO1 single-pass membrane protein with coiled-coil domains 1 [ Homo sapiens (human) ]

Gene ID: 255798, updated on 22-Sep-2022

Summary

Official Symbol
SMCO1provided by HGNC
Official Full Name
single-pass membrane protein with coiled-coil domains 1provided by HGNC
Primary source
HGNC:HGNC:27407
See related
Ensembl:ENSG00000214097 AllianceGenome:HGNC:27407
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C3orf43
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward heart (RPKM 14.0) See more
Orthologs
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Genomic context

See SMCO1 in Genome Data Viewer
Location:
3q29
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (196506879..196520955, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (199226058..199234635, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (196233750..196242217, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene UBX domain protein 7 Neighboring gene UBXN7 antisense RNA 1 Neighboring gene ring finger protein 168 Neighboring gene uncharacterized LOC105374306 Neighboring gene uncharacterized LOC105374307 Neighboring gene ribosomal protein S29 pseudogene 3 Neighboring gene WD repeat domain 53

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41923, MGC141734, MGC141735, DKFZp313B0440

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
single-pass membrane and coiled-coil domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077657.3NP_001071125.1  single-pass membrane and coiled-coil domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001071125.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK123917, AL833140, BC118636
    Consensus CDS
    CCDS43192.1
    UniProtKB/Swiss-Prot
    B3KW20, Q147U7
    Related
    ENSP00000380671.2, ENST00000397537.3
    Conserved Domains (1) summary
    pfam15080
    Location:19213
    DUF4547; Domain of unknown function (DUF4547)
  2. NM_001320473.2NP_001307402.1  single-pass membrane and coiled-coil domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' terminal exon, resulting in a distinct 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) has a distinct N-terminus, and is shorter than isoform 1.
    Source sequence(s)
    AL833140, AL833443
    UniProtKB/Swiss-Prot
    Q147U7
    Conserved Domains (1) summary
    pfam15080
    Location:11205
    DUF4547; Domain of unknown function (DUF4547)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    196506879..196520955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453435.2XP_024309203.1  single-pass membrane and coiled-coil domain-containing protein 1 isoform X1

    Conserved Domains (1) summary
    pfam15080
    Location:17211
    DUF4547; Domain of unknown function (DUF4547)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    199226058..199234635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)