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Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta [ Rattus norvegicus (Norway rat) ]

Gene ID: 25578, updated on 9-Sep-2018

Summary

Official Symbol
Ywhazprovided by RGD
Official Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zetaprovided by RGD
Primary source
RGD:3980
See related
Ensembl:ENSRNOG00000008195
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
14-3-3z
Summary
30kDa component of the mitochondrial import stimulation factor, a protein complex that facilitates the import of in vitro synthesized precursor proteins into mitochondria [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 1746.4), Adrenal (RPKM 1156.7) and 9 other tissues See more
Orthologs

Genomic context

See Ywhaz in Genome Data Viewer
Location:
7q22
Exon count:
7
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (75573553..75598295, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (75719688..75744428, complement)

Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351481 Neighboring gene Ac1254 Neighboring gene uncharacterized LOC103692887 Neighboring gene uncharacterized LOC100910524

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
ion channel binding IEA
Inferred from Electronic Annotation
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein domain specific binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Golgi reassembly IEA
Inferred from Electronic Annotation
more info
 
Golgi reassembly ISO
Inferred from Sequence Orthology
more info
 
establishment of Golgi localization IEA
Inferred from Electronic Annotation
more info
 
establishment of Golgi localization ISO
Inferred from Sequence Orthology
more info
 
histamine secretion by mast cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein targeting IEA
Inferred from Electronic Annotation
more info
 
protein targeting ISO
Inferred from Sequence Orthology
more info
 
protein targeting to mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell death IEA
Inferred from Electronic Annotation
more info
 
regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
regulation of synapse maturation IEA
Inferred from Electronic Annotation
more info
 
regulation of synapse maturation ISO
Inferred from Sequence Orthology
more info
 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
synaptic target recognition IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
 
mast cell granule IEA
Inferred from Electronic Annotation
more info
 
melanosome IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
14-3-3 protein zeta/delta
Names
KCIP-1
mitochondrial import stimulation factor S1 subunit
protein kinase C inhibitor protein 1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013011.3NP_037143.2  14-3-3 protein zeta/delta

    See identical proteins and their annotated locations for NP_037143.2

    Status: PROVISIONAL

    Source sequence(s)
    BC070941
    UniProtKB/Swiss-Prot
    P63102
    Related
    ENSRNOP00000030885.4, ENSRNOT00000035628.5
    Conserved Domains (1) summary
    cd10022
    Location:2230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

    Range
    75573553..75598295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241529.3XP_006241591.1  14-3-3 protein zeta/delta isoform X1

    See identical proteins and their annotated locations for XP_006241591.1

    UniProtKB/Swiss-Prot
    P63102
    Conserved Domains (1) summary
    cd10022
    Location:2230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

Alternate Rn_Celera

Genomic

  1. AC_000075.1 Alternate Rn_Celera

    Range
    65020398..65042696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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