Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ywhaqprovided by RGD
Official Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, thetaprovided by RGD
Primary source: RGD:3979
See related: Ensembl:ENSRNOG00000051650 AllianceGenome:RGD:3979
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: 14-3-3t
Summary: Enables 14-3-3 protein binding activity and transmembrane transporter binding activity. Involved in negative regulation of monoatomic ion transmembrane transport. Part of protein-containing complex. Is active in synapse. Orthologous to human YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta). [provided by Alliance of Genome Resources, May 2025]
Expression: Biased expression in Adrenal (RPKM 1765.7), Brain (RPKM 1528.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (46664358..46694875, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (40935714..40966240, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (43463294..43493816, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

14-3-3theta; is a binding partner of rEag1 and may modulate the functional expression of the K(+) channel in neurons.
Title: 14-3-3θ is a binding partner of rat Eag1 potassium channels.
Results showed that sepsis alters the expression of the 14-3-3 theta; isoform in a time-, cell-, and topography-dependent manner, with the hippocampus, Purkinje cells, and glia-like cells showed intense immunohistochemical reactivity.
Title: Alternations of 14-3-3 θ and β protein levels in brain during experimental sepsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143719 (e-PCR)
- UniSTS:232965

Ywhaq (e-PCR), detects polymorphism
- UniSTS:526907

RH126547 (e-PCR)
- UniSTS:208786

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monoatomic ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein targeting	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in substantia nigra development	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 14-3-3 protein theta

Names: 14-3-3 protein tau; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013053.1 → NP_037185.1 14-3-3 protein theta

See identical proteins and their annotated locations for NP_037185.1

Status: PROVISIONAL

Source sequence(s)

D17614

UniProtKB/Swiss-Prot

P68255

UniProtKB/TrEMBL

A0A8L2R4Y2, A6HAW8

Related

ENSRNOP00000072011.3, ENSRNOT00000077786.3

Conserved Domains (1) summary

cd10023
Location:1 → 234

14-3-3_theta; 14-3-3 theta/tau (theta in mice, tau in human), an isoform of 14-3-3 protein