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DYNLT2B dynein light chain Tctex-type 2B [ Homo sapiens (human) ]

Gene ID: 255758, updated on 22-Jun-2021

Summary

Official Symbol
DYNLT2Bprovided by HGNC
Official Full Name
dynein light chain Tctex-type 2Bprovided by HGNC
Primary source
HGNC:HGNC:28482
See related
Ensembl:ENSG00000213123 MIM:617353
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRTD17; TCTEX1D2
Summary
Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains. This gene encodes a subunit of the human cytoplasmic dynein-2 complex. Mutations in this gene are associated with short-rib thoracic dysplasia 17 with or without polydactyly. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]
Expression
Broad expression in testis (RPKM 12.7), brain (RPKM 6.1) and 23 other tissues See more
Orthologs
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Genomic context

See DYNLT2B in Genome Data Viewer
Location:
3q29
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (196291219..196318240, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (196018090..196045111, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374304 Neighboring gene solute carrier family 51 subunit alpha Neighboring gene phosphate cytidylyltransferase 1A, choline Neighboring gene TM4SF19-DYNLT2B readthrough (NMD candidate) Neighboring gene uncharacterized LOC107986031 Neighboring gene TM4SF19 antisense RNA 1 Neighboring gene transmembrane 4 L six family member 19 Neighboring gene Sharpr-MPRA regulatory region 3422

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Readthrough TM4SF19-DYNLT2B

Readthrough gene: TM4SF19-DYNLT2B, Included gene: TM4SF19

Potential readthrough

Included gene: PCYT1A

Homology

Clone Names

  • MGC33212

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dynein intermediate chain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intraciliary retrograde transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of intraciliary retrograde transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with axoneme IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with centrosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with ciliary base IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cytoplasmic dynein complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with interphase microtubule organizing center IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dynein light chain Tctex-type protein 2B
Names
Tctex1 domain containing 2
tctex1 domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054930.1 RefSeqGene

    Range
    5055..32076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001351628.2NP_001338557.1  dynein light chain Tctex-type protein 2B isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC069257
    Conserved Domains (1) summary
    pfam03645
    Location:44127
    Tctex-1; Tctex-1 family
  2. NM_152773.5NP_689986.2  dynein light chain Tctex-type protein 2B isoform 2

    See identical proteins and their annotated locations for NP_689986.2

    Status: REVIEWED

    Source sequence(s)
    BC021177, BM548106, BM983853
    Consensus CDS
    CCDS33929.1
    UniProtKB/Swiss-Prot
    Q8WW35
    Related
    ENSP00000324323.5, ENST00000325318.10
    Conserved Domains (1) summary
    pfam03645
    Location:44140
    Tctex-1; Tctex-1 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    196291219..196318240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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