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H2BC1 H2B clustered histone 1 [ Homo sapiens (human) ]

Gene ID: 255626, updated on 3-Feb-2021

Summary

Official Symbol
H2BC1provided by HGNC
Official Full Name
H2B clustered histone 1provided by HGNC
Primary source
HGNC:HGNC:18730
See related
Ensembl:ENSG00000146047 MIM:609904
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STBP; TH2B; H2BFU; TSH2B; hTSH2B; TSH2B.1; HIST1H2BA; bA317E16.3
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Orthologs
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Genomic context

See H2BC1 in Genome Data Viewer
Location:
6p22.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (25726777..25727345)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (25727005..25727573)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene secretagogin, EF-hand calcium binding protein Neighboring gene PRELID1 pseudogene 2 Neighboring gene solute carrier family 17 member 1 Neighboring gene H2A clustered histone 1 Neighboring gene H2B clustered histone 2, pseudogene Neighboring gene H2A clustered histone 2, pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
mononuclear cell migration IEA
Inferred from Electronic Annotation
more info
 
nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
nucleosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleosome disassembly ISS
Inferred from Sequence or Structural Similarity
more info
 
plasminogen activation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of binding IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination TAS
Traceable Author Statement
more info
 
spermatogenesis, exchange of chromosomal proteins ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
chromosome, telomeric region HDA PubMed 
extrinsic component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleosome ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus HDA PubMed 

General protein information

Preferred Names
histone H2B type 1-A
Names
H2B histone family, member U, (testis-specific)
histone 1, H2ba
histone H2B, testis
histone cluster 1 H2B family member a
histone cluster 1, H2ba
testis-specific histone H2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_170610.3NP_733759.1  histone H2B type 1-A

    See identical proteins and their annotated locations for NP_733759.1

    Status: REVIEWED

    Source sequence(s)
    AL512384
    Consensus CDS
    CCDS4563.1
    UniProtKB/Swiss-Prot
    Q96A08
    Related
    ENSP00000274764.2, ENST00000274764.4
    Conserved Domains (1) summary
    smart00427
    Location:29125
    H2B; Histone H2B

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    25726777..25727345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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