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Abcc8 ATP binding cassette subfamily C member 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25559, updated on 18-Apr-2019

Summary

Official Symbol
Abcc8provided by RGD
Official Full Name
ATP binding cassette subfamily C member 8provided by RGD
Primary source
RGD:3786
See related
Ensembl:ENSRNOG00000021130
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sur; Sur1
Summary
binds sulfonylurea; subunit of the ATP-sensitive potassium channel K(ATP), which is composed of Sur1 and the inwardly rectifying K(+) channel subunit, Kir6.2 [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
Expression
Biased expression in Heart (RPKM 53.0), Brain (RPKM 31.7) and 4 other tissues See more
Orthologs

Genomic context

See Abcc8 in Genome Data Viewer
Location:
1q22
Exon count:
39
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (102110708..102191287, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (103194473..103275508, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene band 4.1-like protein 5-like Neighboring gene potassium voltage-gated channel subfamily J member 11 Neighboring gene USH1 protein network component harmonin Neighboring gene otogelin Neighboring gene uncharacterized LOC103691114

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity, coupled to transmembrane movement of substances IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion channel binding ISO
Inferred from Sequence Orthology
more info
PubMed 
contributes_to potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium channel activity ISO
Inferred from Sequence Orthology
more info
PubMed 
potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
sulfonylurea receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of low-density lipoprotein particle clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of maintenance of permeability of blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuroblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tight junction disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of uterine smooth muscle relaxation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of voltage-gated potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
potassium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to drug IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to insulin IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
response to pH IDA
Inferred from Direct Assay
more info
PubMed 
response to zinc ion IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
inward rectifying potassium channel IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inward rectifying potassium channel IDA
Inferred from Direct Assay
more info
PubMed 
inward rectifying potassium channel ISO
Inferred from Sequence Orthology
more info
PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ATP-binding cassette sub-family C member 8
Names
ATP-binding cassette transporter sub-family C member 8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ATP-binding cassette, subfamily C (CFTR/MRP), member 8
sulfonylurea receptor 1
sulphonylurea receptor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013039.2NP_037171.2  ATP-binding cassette sub-family C member 8

    See identical proteins and their annotated locations for NP_037171.2

    Status: PROVISIONAL

    Source sequence(s)
    X97279
    UniProtKB/Swiss-Prot
    Q09429
    Related
    ENSRNOP00000028696.6, ENSRNOT00000028696.7
    Conserved Domains (4) summary
    cd03288
    Location:13431582
    ABCC_SUR2; ATP-binding cassette domain 2 of the sulfonylurea receptor SUR
    TIGR01271
    Location:2231582
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    pfam00664
    Location:10171295
    ABC_membrane; ABC transporter transmembrane region
    cl21455
    Location:679907
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    102110708..102191287 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759321.2XP_008757543.1  ATP-binding cassette sub-family C member 8 isoform X2

    See identical proteins and their annotated locations for XP_008757543.1

    UniProtKB/TrEMBL
    Q70X90
    Conserved Domains (3) summary
    TIGR01271
    Location:1971556
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    pfam00664
    Location:9911269
    ABC_membrane; ABC transporter transmembrane region
    cl21455
    Location:13171556
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_008759320.2XP_008757542.1  ATP-binding cassette sub-family C member 8 isoform X1

    UniProtKB/Swiss-Prot
    Q09429
    Conserved Domains (4) summary
    cd03288
    Location:13421581
    ABCC_SUR2; ATP-binding cassette domain 2 of the sulfonylurea receptor SUR
    TIGR01271
    Location:2231581
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    pfam00664
    Location:10161294
    ABC_membrane; ABC transporter transmembrane region
    cl21455
    Location:679906
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    90849685..90928224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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