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Stxbp1 syntaxin binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25558, updated on 17-Nov-2020

Summary

Official Symbol
Stxbp1provided by RGD
Official Full Name
syntaxin binding protein 1provided by RGD
Primary source
RGD:3785
See related
Ensembl:ENSRNOG00000015420
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sec1; nSec1; NSEC1A; n-sec1; rbSec1; ANC18HA; Unc18-1; rbSec1A; rbSec1B; Munc18-1
Summary
inhibits binding of synaptobrevin and SNAP-25 to syntaxin 1A to modulate SNARE complex formation; acts to regulate neurotransmission [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 419.0), Spleen (RPKM 49.5) and 5 other tissues See more
Orthologs

Genomic context

See Stxbp1 in Genome Data Viewer
Location:
3p11
Exon count:
20
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11823779..11885479, complement)
106 current Rn_Celera (GCF_000002265.2) 3 AC_000071.1 (10816317..10877576, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (17160752..17221893, complement)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene torsin family 2, member A Neighboring gene tetratricopeptide repeat domain 16 Neighboring gene cilia and flagella associated protein 157 Neighboring gene peptidyl-tRNA hydrolase 1 homolog Neighboring gene niban apoptosis regulator 2 Neighboring gene leucine rich repeat and sterile alpha motif containing 1 Neighboring gene ribosomal protein L12

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
SNARE binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
phospholipase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein N-terminus binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
syntaxin binding IDA
Inferred from Direct Assay
more info
PubMed 
syntaxin binding ISO
Inferred from Sequence Orthology
more info
 
syntaxin-1 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
syntaxin-1 binding IDA
Inferred from Direct Assay
more info
PubMed 
syntaxin-1 binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
SNARE complex assembly ISO
Inferred from Sequence Orthology
more info
 
axon target recognition ISO
Inferred from Sequence Orthology
more info
 
cellular response to interferon-gamma ISO
Inferred from Sequence Orthology
more info
 
developmental process involved in reproduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
exocytosis ISO
Inferred from Sequence Orthology
more info
 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-term synaptic depression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of SNARE complex assembly TAS
Traceable Author Statement
more info
PubMed 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
 
neuromuscular synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
platelet aggregation ISO
Inferred from Sequence Orthology
more info
 
platelet degranulation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glutamate secretion, neurotransmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vesicle docking IDA
Inferred from Direct Assay
more info
PubMed 
presynaptic dense core vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of acrosomal vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic vesicle priming IDA
Inferred from Direct Assay
more info
PubMed 
regulation of synaptic vesicle priming IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of vesicle fusion IDA
Inferred from Direct Assay
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
synaptic vesicle maturation ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle priming ISO
Inferred from Sequence Orthology
more info
 
vesicle docking involved in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle docking involved in exocytosis ISO
Inferred from Sequence Orthology
more info
 
vesicle docking involved in exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
axon ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
cytosol TAS
Traceable Author Statement
more info
PubMed 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
platelet alpha granule ISO
Inferred from Sequence Orthology
more info
 
postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
presynapse IDA
Inferred from Direct Assay
more info
PubMed 
presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
terminal bouton HDA PubMed 

General protein information

Preferred Names
syntaxin-binding protein 1
Names
p67
protein unc-18 homolog 1
protein unc-18 homolog A
unc-18 homolog
unc-18-1
unc-18A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013038.3NP_037170.1  syntaxin-binding protein 1

    See identical proteins and their annotated locations for NP_037170.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088850
    UniProtKB/Swiss-Prot
    P61765
    Related
    ENSRNOP00000021178.5, ENSRNOT00000021178.8
    Conserved Domains (1) summary
    pfam00995
    Location:29575
    Sec1; Sec1 family

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    11823779..11885479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233939.3XP_006234001.1  syntaxin-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006234001.1

    UniProtKB/Swiss-Prot
    P61765
    Related
    ENSRNOP00000021189.4, ENSRNOT00000021189.5
    Conserved Domains (1) summary
    pfam00995
    Location:29575
    Sec1; Sec1 family

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    10816317..10877576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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