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RNF144B ring finger protein 144B [ Homo sapiens (human) ]

Gene ID: 255488, updated on 8-Jul-2021

Summary

Official Symbol
RNF144Bprovided by HGNC
Official Full Name
ring finger protein 144Bprovided by HGNC
Primary source
HGNC:HGNC:21578
See related
Ensembl:ENSG00000137393 MIM:618869
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIR2; IBRDC2; p53RFP; bA528A10.3
Expression
Broad expression in thyroid (RPKM 30.0), lung (RPKM 13.0) and 20 other tissues See more
Orthologs
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Genomic context

See RNF144B in Genome Data Viewer
Location:
6p22.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (18387329..18468870)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (18387581..18469101)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene inosine monophosphate dehydrogenase 1 pseudogene 9 Neighboring gene DEAD-box helicase 18 pseudogene 3 Neighboring gene uncharacterized LOC105374955 Neighboring gene MIR548A1 host gene Neighboring gene VISTA enhancer hs1052

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study link novel loci to endometriosis.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0161, MGC71786

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ubiquitin ligase complex IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF144B
Names
IBR domain containing 2
IBR domain-containing protein 2
p53-inducible RING finger protein
NP_877434.2
XP_005249043.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182757.4NP_877434.2  E3 ubiquitin-protein ligase RNF144B

    See identical proteins and their annotated locations for NP_877434.2

    Status: VALIDATED

    Source sequence(s)
    AK096832, AL138725
    Consensus CDS
    CCDS34345.1
    UniProtKB/Swiss-Prot
    Q7Z419
    Related
    ENSP00000259939.4, ENST00000259939.4
    Conserved Domains (3) summary
    smart00647
    Location:101166
    IBR; In Between Ring fingers
    cd16778
    Location:2884
    mRING-HC-C4C4_RBR_RNF144B; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144B (RNF144B)
    pfam01485
    Location:190225
    IBR; IBR domain, a half RING-finger domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    18387329..18468870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248986.3XP_005249043.1  E3 ubiquitin-protein ligase RNF144B isoform X1

    Conserved Domains (2) summary
    smart00647
    Location:66131
    IBR; In Between Ring fingers
    pfam01485
    Location:155190
    IBR; IBR domain, a half RING-finger domain
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