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Sele selectin E [ Rattus norvegicus (Norway rat) ]

Gene ID: 25544, updated on 12-Aug-2018

Summary

Official Symbol
Seleprovided by RGD
Official Full Name
selectin Eprovided by RGD
Primary source
RGD:3654
See related
Ensembl:ENSRNOG00000002723 Vega:OTTRNOG00000001146
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
facilitates recruitment of leukocytes into sites of inflammation; plays a role in cell adhesion [RGD, Feb 2006]
Expression
Biased expression in Heart (RPKM 11.4), Lung (RPKM 6.1) and 6 other tissues See more
Orthologs

Genomic context

See Sele in Genome Data Viewer
Location:
13q23
Exon count:
14
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (82355234..82365323)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (87234842..87244746)

Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555981 Neighboring gene similar to peptidylprolyl isomerase D Neighboring gene similar to adenylate kinase 2 isoform b Neighboring gene similar to COP9 signalosome complex subunit 8 (JAB1-containing signalosome subunit 8) Neighboring gene selectin L

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)
    AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
  • AGE-RAGE signaling pathway in diabetic complications, conserved biosystem (from KEGG)
    AGE-RAGE signaling pathway in diabetic complications, conserved biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
  • African trypanosomiasis, organism-specific biosystem (from KEGG)
    African trypanosomiasis, organism-specific biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
  • African trypanosomiasis, conserved biosystem (from KEGG)
    African trypanosomiasis, conserved biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Malaria, organism-specific biosystem (from KEGG)
    Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
  • Malaria, conserved biosystem (from KEGG)
    Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
  • TNF signaling pathway, organism-specific biosystem (from KEGG)
    TNF signaling pathway, organism-specific biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
  • TNF signaling pathway, conserved biosystem (from KEGG)
    TNF signaling pathway, conserved biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
oligosaccharide binding IEA
Inferred from Electronic Annotation
more info
 
oligosaccharide binding ISO
Inferred from Sequence Orthology
more info
 
phospholipase binding IEA
Inferred from Electronic Annotation
more info
 
phospholipase binding ISO
Inferred from Sequence Orthology
more info
 
sialic acid binding IEA
Inferred from Electronic Annotation
more info
 
sialic acid binding ISO
Inferred from Sequence Orthology
more info
 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
actin filament-based process IEA
Inferred from Electronic Annotation
more info
 
actin filament-based process ISO
Inferred from Sequence Orthology
more info
 
activation of phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 
activation of phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
leukocyte migration IEP
Inferred from Expression Pattern
more info
PubMed 
leukocyte tethering or rolling IEA
Inferred from Electronic Annotation
more info
 
leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of leukocyte migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor internalization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
response to cytokine IEP
Inferred from Expression Pattern
more info
PubMed 
response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 
response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
caveola IEA
Inferred from Electronic Annotation
more info
 
caveola ISO
Inferred from Sequence Orthology
more info
 
cellular_component ND
No biological Data available
more info
 
clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 
clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
 
cortical cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cortical cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E-selectin
Names
CD62 antigen-like family member E
ELAM-1
LECAM2
endothelial leukocyte adhesion molecule 1
leukocyte-endothelial cell adhesion molecule 2
selectin, endothelial cell

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138879.1NP_620234.1  E-selectin precursor

    See identical proteins and their annotated locations for NP_620234.1

    Status: PROVISIONAL

    Source sequence(s)
    L25527
    UniProtKB/Swiss-Prot
    P98105
    Related
    ENSRNOP00000068171.1, OTTRNOP00000000997, ENSRNOT00000076757.1, OTTRNOT00000001749
    Conserved Domains (3) summary
    cd00033
    Location:243301
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03592
    Location:22140
    CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
    cd00054
    Location:148174
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

    Range
    82355234..82365323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769608.2XP_008767830.1  E-selectin isoform X2

    See identical proteins and their annotated locations for XP_008767830.1

    Conserved Domains (4) summary
    cd00033
    Location:250308
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03592
    Location:29147
    CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
    PHA02927
    Location:310555
    PHA02927; secreted complement-binding protein; Provisional
    cd00054
    Location:155181
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  2. XM_017598678.1XP_017454167.1  E-selectin isoform X1

    UniProtKB/TrEMBL
    A0A0H2UHU5
    Related
    ENSRNOP00000034797.3, ENSRNOT00000030677.3
    Conserved Domains (3) summary
    cd00033
    Location:250308
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03592
    Location:29147
    CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
    cd00054
    Location:155181
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

Alternate Rn_Celera

Genomic

  1. AC_000081.1 Alternate Rn_Celera

    Range
    76136932..76146318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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