U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sele selectin E [ Rattus norvegicus (Norway rat) ]

Gene ID: 25544, updated on 22-May-2022

Summary

Official Symbol
Seleprovided by RGD
Official Full Name
selectin Eprovided by RGD
Primary source
RGD:3654
See related
Ensembl:ENSRNOG00000002723 AllianceGenome:RGD:3654
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including oligosaccharide binding activity; phospholipase binding activity; and sialic acid binding activity. Involved in inflammatory response; leukocyte migration; and response to cytokine. Predicted to be located in several cellular components, including caveola; clathrin-coated pit; and perinuclear region of cytoplasm. Predicted to be integral component of plasma membrane. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; brain ischemia; cerebrovascular disease; and coronary artery disease. Orthologous to human SELE (selectin E). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 11.4), Lung (RPKM 6.1) and 6 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Sele in Genome Data Viewer
Location:
13q23
Exon count:
14
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (76402841..76412741)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (82355234..82365323)

Chromosome 13 - NC_051348.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555981 Neighboring gene peptidylprolyl isomerase D, pseudogene 19 Neighboring gene adenylate kinase 2, pseudogene 2 Neighboring gene COP9 signalosome subunit 8, pseudogene 1 Neighboring gene selectin L

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables oligosaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables oligosaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase binding ISO
Inferred from Sequence Orthology
more info
 
enables sialic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sialic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin filament-based process ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion TAS
Traceable Author Statement
more info
PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte migration IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of leukocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte tethering or rolling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of leukocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte tethering or rolling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cytokine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to cytokine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
is_active_in cellular_component ND
No biological Data available
more info
 
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
 
located_in cortical cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E-selectin
Names
CD62 antigen-like family member E
ELAM-1
LECAM2
endothelial leukocyte adhesion molecule 1
leukocyte-endothelial cell adhesion molecule 2
selectin, endothelial cell

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138879.1NP_620234.1  E-selectin precursor

    See identical proteins and their annotated locations for NP_620234.1

    Status: PROVISIONAL

    Source sequence(s)
    L25527
    UniProtKB/Swiss-Prot
    P98105
    Related
    ENSRNOP00000068171.2, ENSRNOT00000076757.2
    Conserved Domains (3) summary
    cd00033
    Location:243301
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03592
    Location:22140
    CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
    cd00054
    Location:148174
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051348.1 Reference mRatBN7.2 Primary Assembly

    Range
    76402841..76412741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017598678.2XP_017454167.1  E-selectin isoform X1

    UniProtKB/TrEMBL
    A0A0H2UHU5
    Conserved Domains (3) summary
    cd00033
    Location:250308
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03592
    Location:29147
    CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
    cd00054
    Location:155181
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  2. XM_008769608.3XP_008767830.1  E-selectin isoform X2

    See identical proteins and their annotated locations for XP_008767830.1

    Related
    ENSRNOP00000034797.4, ENSRNOT00000030677.4
    Conserved Domains (4) summary
    cd00033
    Location:250308
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03592
    Location:29147
    CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
    PHA02927
    Location:310555
    PHA02927; secreted complement-binding protein; Provisional
    cd00054
    Location:155181
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...