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RASGEF1C RasGEF domain family member 1C [ Homo sapiens (human) ]

Gene ID: 255426, updated on 5-Aug-2022

Summary

Official Symbol
RASGEF1Cprovided by HGNC
Official Full Name
RasGEF domain family member 1Cprovided by HGNC
Primary source
HGNC:HGNC:27400
See related
Ensembl:ENSG00000146090 AllianceGenome:HGNC:27400
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity and small GTPase mediated signal transduction. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 6.2), testis (RPKM 3.8) and 2 other tissues See more
Orthologs
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Genomic context

See RASGEF1C in Genome Data Viewer
Location:
5q35.3
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (180100795..180209211, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (180655720..180693702, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (179527795..179636211, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene histone PARylation factor 1 pseudogene Neighboring gene GATA motif-containing MPRA enhancer 81 Neighboring gene Sharpr-MPRA regulatory region 5800 Neighboring gene U2 spliceosomal RNA Neighboring gene ribosomal protein S8 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35841

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras-GEF domain-containing family member 1C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175062.4NP_778232.2  ras-GEF domain-containing family member 1C

    See identical proteins and their annotated locations for NP_778232.2

    Status: VALIDATED

    Source sequence(s)
    AC104115, AC122713, BC036802, BF967301, BM729117
    Consensus CDS
    CCDS4452.1
    UniProtKB/Swiss-Prot
    Q8N431, Q8NA49
    Related
    ENSP00000354963.4, ENST00000361132.9
    Conserved Domains (2) summary
    cd06224
    Location:42160
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:200447
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    180100795..180209211 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    180655720..180693702 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001031799.1: Suppressed sequence

    Description
    NM_001031799.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.