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Rabggtb Rab geranylgeranyltransferase subunit beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 25533, updated on 12-Aug-2026
Official Symbol
Rabggtbprovided by RGD
Official Full Name
Rab geranylgeranyltransferase subunit betaprovided by RGD
Primary source
RGD:3530
See related
Ensembl:ENSRNOG00000009992 AllianceGenome:RGD:3530
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables several functions, including Rab geranylgeranyltransferase activity; small GTPase binding activity; and zinc ion binding activity. Involved in protein geranylgeranylation. Part of Rab-protein geranylgeranyltransferase complex. Orthologous to human RABGGTB (Rab geranylgeranyltransferase subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Heart (RPKM 515.3), Muscle (RPKM 394.0) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Rabggtb in Genome Data Viewer
Location:
2q45
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (245504586..245510878, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (242844758..242850951, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 17 Neighboring gene mutS homolog 4 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA, C/D box 45B Neighboring gene small nucleolar RNA, C/D box 45A Neighboring gene small nucleolar RNA, C/D box 45C Neighboring gene acyl-CoA dehydrogenase medium chain Neighboring gene small nucleolar RNA SNORA15 Neighboring gene uncharacterized LOC134485696

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase. Deraeve C, et al. J Am Chem Soc, 2012 May 2. PMID 22480322
  2. Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors. Tan KT, et al. J Med Chem, 2009 Dec 24. PMID 19894725
  3. Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex. Guo Z, et al. Angew Chem Int Ed Engl, 2008. PMID 18399557
  4. Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution. Zhang H, et al. Structure, 2000 Mar 15. PMID 10745007
  5. Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic β cells. Arora DK, et al. Islets, 2012 Sep-Oct. PMID 23114750, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Rab geranylgeranyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables Rab geranylgeranyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to Rab geranylgeranyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables isoprenoid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein geranylgeranyltransferase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein geranylgeranyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein geranylgeranyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein prenyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein geranylgeranylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Rab-protein geranylgeranyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rab-protein geranylgeranyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Rab-protein geranylgeranyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
geranylgeranyl transferase type-2 subunit beta
Names
GGTase-II-beta
Rab geranylgeranyl transferase componenet, subunit beta
Rab geranylgeranyltransferase, beta subunit
geranylgeranyl transferase type II subunit beta
rab GG transferase beta
rab GGTase beta
rab geranyl-geranyltransferase subunit beta
type II protein geranyl-geranyltransferase subunit beta
NP_619715.2
XP_063137436.1
XP_063137437.1
XP_063137438.1
XP_063137439.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138708.3 → NP_619715.2  geranylgeranyl transferase type-2 subunit beta

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q08603
    UniProtKB/TrEMBL
    A6HWN7, Q68G48
    Related
    ENSRNOP00000061541.3, ENSRNOT00000065997.3
    Conserved Domains (1) summary
    cd02894
    Location:18 → 301
    GGTase-II; Geranylgeranyltransferase type II (GGTase-II)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-IIs are a subgroup of the protein prenyltransferase family of lipid-modifying ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    245504586..245510878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281366.1 → XP_063137436.1  geranylgeranyl transferase type-2 subunit beta isoform X1

    UniProtKB/Swiss-Prot
    Q08603

  2. XM_063281367.1 → XP_063137437.1  geranylgeranyl transferase type-2 subunit beta isoform X2

  3. XM_063281368.1 → XP_063137438.1  geranylgeranyl transferase type-2 subunit beta isoform X3

    UniProtKB/Swiss-Prot
    Q08603

  4. XM_063281369.1 → XP_063137439.1  geranylgeranyl transferase type-2 subunit beta isoform X4

RNA

  1. XR_010063585.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08603.1 GenPept UniProtKB/Swiss-Prot:Q08603

Gene LinkOut

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