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GABPB1 GA binding protein transcription factor subunit beta 1 [ Homo sapiens (human) ]

Gene ID: 2553, updated on 6-Jan-2019

Summary

Official Symbol
GABPB1provided by HGNC
Official Full Name
GA binding protein transcription factor subunit beta 1provided by HGNC
Primary source
HGNC:HGNC:4074
See related
Ensembl:ENSG00000104064 MIM:600610
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
E4TF1; GABPB; BABPB2; E4TF1B; GABPB2; NRF2B1; NRF2B2; GABPB-1; E4TF1-47; E4TF1-53
Summary
This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Annotation information
Note: In August, 2008, the nomenclature of the GA binding protein transcription factors was clarified. The gene on Hsa1q was named GABPB2 and the gene on Hsa15q was named GABPB1. [24 Sep 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 6.9), lymph node (RPKM 6.8) and 25 other tissues See more
Orthologs

Genomic context

See GABPB1 in Genome Data Viewer
Location:
15q21.2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (50277192..50359306, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (50569389..50647605, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 27 member 2 Neighboring gene RNA, 7SL, cytoplasmic 494, pseudogene Neighboring gene histidine decarboxylase Neighboring gene GABPB1 intronic transcript Neighboring gene RNA, U6 small nuclear 94, pseudogene Neighboring gene GABPB1 antisense RNA 1 Neighboring gene microRNA 4712 Neighboring gene adenosylhomocysteinase pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of GA binding protein transcription factor, beta subunit 1 (GABPB1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
GA-binding protein subunit beta-1
Names
GA binding protein transcription factor beta subunit 1 transcript variant gamma-2
GABP subunit beta-2
nuclear respiratory factor 2
transcription factor E4TF1-47
transcription factor E4TF1-53
NP_001307839.1
NP_001307844.1
NP_002032.2
NP_005245.2
NP_057738.1
NP_057739.1
NP_852092.1
XP_005254331.1
XP_011519728.1
XP_016877542.1
XP_016877543.1
XP_024305651.1
XP_024305652.1
XP_024305653.1
XP_024305654.1
XP_024305655.1
XP_024305656.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029475.2 RefSeqGene

    Range
    5001..83217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001320910.1NP_001307839.1  GA-binding protein subunit beta-1 isoform beta 1

    Status: REVIEWED

    Source sequence(s)
    AC022087
    Consensus CDS
    CCDS32239.1
    UniProtKB/Swiss-Prot
    Q06547
    Conserved Domains (3) summary
    cd00204
    Location:34156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:3868
    ANK; ANK repeat [structural motif]
    cl25742
    Location:323389
    ERM; Ezrin/radixin/moesin family
  2. NM_001320915.1NP_001307844.1  GA-binding protein subunit beta-1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022087
    Conserved Domains (3) summary
    cd00204
    Location:34156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:3868
    ANK; ANK repeat [structural motif]
    cl25742
    Location:322388
    ERM; Ezrin/radixin/moesin family
  3. NM_002041.4NP_002032.2  GA-binding protein subunit beta-1 isoform gamma 1

    See identical proteins and their annotated locations for NP_002032.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (gamma 1) uses an alternate in-frame splice site in the 3' coding region, compared to variant beta 1, resulting in a shorter isoform (gamma 1).
    Source sequence(s)
    DA156248, U13047
    Consensus CDS
    CCDS45258.1
    UniProtKB/Swiss-Prot
    Q06547
    Related
    ENSP00000395771.2, ENST00000429662.6
    Conserved Domains (2) summary
    cd00204
    Location:34156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:3868
    ANK; ANK repeat [structural motif]
  4. NM_005254.5NP_005245.2  GA-binding protein subunit beta-1 isoform beta 1

    See identical proteins and their annotated locations for NP_005245.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta 1) encodes the longest isoform (beta 1).
    Source sequence(s)
    AI631183, BC036080, DA156248, U13045
    Consensus CDS
    CCDS32239.1
    UniProtKB/Swiss-Prot
    Q06547
    Related
    ENSP00000220429.8, ENST00000220429.12
    Conserved Domains (3) summary
    cd00204
    Location:34156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:3868
    ANK; ANK repeat [structural motif]
    cl25742
    Location:323389
    ERM; Ezrin/radixin/moesin family
  5. NM_016654.4NP_057738.1  GA-binding protein subunit beta-1 isoform beta 2

    See identical proteins and their annotated locations for NP_057738.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta 2) lacks an alternate in-frame segment, compared to variant beta 1, resulting in a shorter isoform (beta 2) that lacks a 12-amino acid serine-rich region, compared to isoform beta 1.
    Source sequence(s)
    AI631183, BC036080, D13317, DA156248
    Consensus CDS
    CCDS10135.1
    UniProtKB/Swiss-Prot
    Q06547
    UniProtKB/TrEMBL
    A0A024R5X6
    Related
    ENSP00000370259.3, ENST00000380877.7
    Conserved Domains (3) summary
    cd00204
    Location:34156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:3868
    ANK; ANK repeat [structural motif]
    cl25742
    Location:315377
    ERM; Ezrin/radixin/moesin family
  6. NM_016655.4NP_057739.1  GA-binding protein subunit beta-1 isoform gamma 2

    See identical proteins and their annotated locations for NP_057739.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (gamma 2) contains multiple differences compared to variant beta 1, resulting in a shorter isoform (gamma 2) that lacks a 12-amino acid serine-rich region, compared to isoform beta 1. Both this variant (gamma 2) and gamma 3 encode the same isoform (gamma 2), however, they differ in the 5' UTR.
    Source sequence(s)
    DA156248, U13047, U13048
    Consensus CDS
    CCDS10136.1
    UniProtKB/Swiss-Prot
    Q06547
    UniProtKB/TrEMBL
    A0A024R5R5
    Related
    ENSP00000379728.3, ENST00000396464.7
    Conserved Domains (2) summary
    cd00204
    Location:34156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:3868
    ANK; ANK repeat [structural motif]
  7. NM_181427.3NP_852092.1  GA-binding protein subunit beta-1 isoform gamma 2

    See identical proteins and their annotated locations for NP_852092.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (gamma 3) contains multiple differences compared to variant beta 1, resulting in a shorter isoform (gamma 2) that lacks a 12-amino acid serine-rich region, compared to isoform beta 1. Both this variant (gamma 3) and gamma 2 encode the same isoform (gamma 2), however, they differ in the 5' UTR.
    Source sequence(s)
    DA156248, DA502761, U13048
    Consensus CDS
    CCDS10136.1
    UniProtKB/Swiss-Prot
    Q06547
    UniProtKB/TrEMBL
    A0A024R5R5
    Related
    ENSP00000351923.4, ENST00000359031.8
    Conserved Domains (2) summary
    cd00204
    Location:34156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:3868
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    50277192..50359306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449885.1XP_024305653.1  GA-binding protein subunit beta-1 isoform X3

    Conserved Domains (3) summary
    cd00204
    Location:37159
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:4171
    ANK; ANK repeat [structural motif]
    cl25742
    Location:326392
    ERM; Ezrin/radixin/moesin family
  2. XM_024449888.1XP_024305656.1  GA-binding protein subunit beta-1 isoform X7

    Conserved Domains (3) summary
    cd00204
    Location:39161
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:4373
    ANK; ANK repeat [structural motif]
    cl25742
    Location:319381
    ERM; Ezrin/radixin/moesin family
  3. XM_024449884.1XP_024305652.1  GA-binding protein subunit beta-1 isoform X2

    Conserved Domains (3) summary
    cd00204
    Location:39161
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:4373
    ANK; ANK repeat [structural motif]
    cl25742
    Location:331393
    ERM; Ezrin/radixin/moesin family
  4. XM_024449883.1XP_024305651.1  GA-binding protein subunit beta-1 isoform X1

    Conserved Domains (3) summary
    cd00204
    Location:39161
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:4373
    ANK; ANK repeat [structural motif]
    cl25742
    Location:328394
    ERM; Ezrin/radixin/moesin family
  5. XM_017022054.2XP_016877543.1  GA-binding protein subunit beta-1 isoform X9

    Conserved Domains (3) summary
    cd00204
    Location:34156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:3868
    ANK; ANK repeat [structural motif]
    cl25742
    Location:314376
    ERM; Ezrin/radixin/moesin family
  6. XM_011521426.3XP_011519728.1  GA-binding protein subunit beta-1 isoform X9

    See identical proteins and their annotated locations for XP_011519728.1

    Conserved Domains (3) summary
    cd00204
    Location:34156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:3868
    ANK; ANK repeat [structural motif]
    cl25742
    Location:314376
    ERM; Ezrin/radixin/moesin family
  7. XM_024449886.1XP_024305654.1  GA-binding protein subunit beta-1 isoform X5

    Conserved Domains (3) summary
    cd00204
    Location:34156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:3868
    ANK; ANK repeat [structural motif]
    cl25742
    Location:322388
    ERM; Ezrin/radixin/moesin family
  8. XM_005254274.4XP_005254331.1  GA-binding protein subunit beta-1 isoform X4

    See identical proteins and their annotated locations for XP_005254331.1

    UniProtKB/Swiss-Prot
    Q06547
    Conserved Domains (3) summary
    cd00204
    Location:34156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:3868
    ANK; ANK repeat [structural motif]
    cl25742
    Location:323389
    ERM; Ezrin/radixin/moesin family
  9. XM_024449887.1XP_024305655.1  GA-binding protein subunit beta-1 isoform X6

    Conserved Domains (3) summary
    cd00204
    Location:39161
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:4373
    ANK; ANK repeat [structural motif]
    cl25742
    Location:320382
    ERM; Ezrin/radixin/moesin family
  10. XM_017022053.2XP_016877542.1  GA-binding protein subunit beta-1 isoform X8

    UniProtKB/Swiss-Prot
    Q06547
    UniProtKB/TrEMBL
    A0A024R5X6
    Conserved Domains (3) summary
    cd00204
    Location:34156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:3868
    ANK; ANK repeat [structural motif]
    cl25742
    Location:315377
    ERM; Ezrin/radixin/moesin family
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